Impact of Mean Arterial Blood Pressure During the First Seven Days Post Spinal Cord Injury

2010 ◽  
Vol 15 (3) ◽  
pp. 96-106
Author(s):  
Jennifer A. Cohn ◽  
Jerry Wright ◽  
Stephen L. McKenna ◽  
Tamara Bushnik
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Arterial Blood Pressure ◽  
Mean Arterial Blood Pressure ◽  
Arterial Blood ◽  
Cord Injury

The Effect of Elevated Mean Arterial Blood Pressure in Cervical Traumatic Spinal Cord Injury with Hemorrhagic Contusion

2020 ◽  
Vol 144 ◽  
pp. e405-e413
Author(s):  
Harry M. Mushlin ◽  
Noah Lessing ◽  
Aaron P. Wessell ◽  
Timothy Chryssikos ◽  
Nathan Pratt ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Arterial Blood Pressure ◽  
Mean Arterial Blood Pressure ◽  
Traumatic Spinal Cord Injury ◽  
Arterial Blood ◽  
Cord Injury

Influence of Arterial Blood Pressure upon Central Hemorrhagic Necrosis after Severe Spinal Cord Injury

Neurosurgery ◽  
1979 ◽  
Vol 4 (1) ◽  
pp. 53-55 ◽  
Author(s):  
John L. Alderman ◽  
Jewell L. Osterholm ◽  
Benedette R. DʼAmore ◽  
Richard S. Moberg ◽  
John D. Irvin
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Arterial Blood Pressure ◽  
Arterial Blood ◽  
Hemorrhagic Necrosis ◽  
Cord Injury

Influence of arterial blood pressure upon central hemorrhagic necrosis after severe spinal cord injury

Neurosurgery ◽  
1979 ◽  
Vol 4 (1) ◽  
pp. 53???5 ◽  
Author(s):  
J L Alderman ◽  
J L Osterholm ◽  
B R D??Amore ◽  
R S Moberg ◽  
J D Irvin
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Arterial Blood Pressure ◽  
Arterial Blood ◽  
Hemorrhagic Necrosis ◽  
Cord Injury

Increased vascular resistance in paralyzed legs after spinal cord injury is reversible by training

2002 ◽  
Vol 93 (6) ◽  
pp. 1966-1972 ◽  
Author(s):  
Maria T. E. Hopman ◽  
Jan T. Groothuis ◽  
Marcel Flendrie ◽  
Karin H. L. Gerrits ◽  
Sibrand Houtman
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Blood Flow ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Vascular Resistance ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Cord Injury

The purpose of the present study was to determine the effect of a spinal cord injury (SCI) on resting vascular resistance in paralyzed legs in humans. To accomplish this goal, we measured blood pressure and resting flow above and below the lesion (by using venous occlusion plethysmography) in 11 patients with SCI and in 10 healthy controls (C). Relative vascular resistance was calculated as mean arterial pressure in millimeters of mercury divided by the arterial blood flow in milliliters per minute per 100 milliliters of tissue. Arterial blood flow in the sympathetically deprived and paralyzed legs of SCI was significantly lower than leg blood flow in C. Because mean arterial pressure showed no differences between both groups, leg vascular resistance in SCI was significantly higher than in C. Within the SCI group, arterial blood flow was significantly higher and vascular resistance significantly lower in the arms than in the legs. To distinguish between the effect of loss of central neural control vs. deconditioning, a group of nine SCI patients was trained for 6 wk and showed a 30% increase in leg blood flow with unchanged blood pressure levels, indicating a marked reduction in vascular resistance. In conclusion, vascular resistance is increased in the paralyzed legs of individuals with SCI and is reversible by training.

scholarly journals Chronic, complete cervical6–7 cord transection: distinct autonomic and cardiac deficits

2018 ◽  
Vol 124 (6) ◽  
pp. 1471-1482 ◽  
Author(s):  
Heidi L. Lujan ◽  
Anne Tonson ◽  
Robert W. Wiseman ◽  
Stephen E. DiCarlo
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Arterial Blood Pressure ◽  
Histological Examination ◽  
Hormonal Responses ◽  
Sympathetic Preganglionic Neurons ◽  
Supraspinal Control ◽  
Arterial Blood ◽  
Cord Injury ◽  
First Time

Spinal cord injury (SCI) resulting in tetraplegia is a devastating, life-changing insult causing paralysis and sensory impairment as well as distinct autonomic dysfunction that triggers compromised cardiovascular, bowel, bladder, and sexual activity. Life becomes a battle for independence as even routine bodily functions and the smallest activity of daily living become major challenges. Accordingly, there is a critical need for a chronic preclinical model of tetraplegia. This report addresses this critical need by comparing, for the first time, resting-, reflex-, and stress-induced cardiovascular, autonomic, and hormonal responses each week for 4 wk in 12 sham-operated intact rats and 12 rats with chronic, complete C6–7 spinal cord transection. Loss of supraspinal control to all sympathetic preganglionic neurons projecting to the heart and vasculature resulted in a profound bradycardia and hypotension, reduced cardiac sympathetic and parasympathetic tonus, reduced reflex- and stress-induced sympathetic responses, and reduced sympathetic support of blood pressure as well as enhanced reliance on angiotensin to maintain arterial blood pressure. Histological examination of the nucleus ambiguus and stellate ganglia supports the profound and distinct autonomic and cardiac deficits and reliance on angiotensin to maintain cardiovascular stability following chronic, complete cervical6–7 cord transection. NEW & NOTEWORTHY For the first time, resting-, reflex-, and stress-induced cardiovascular, autonomic, and hormonal responses were studied in rats with chronic, complete C6–7 cord transection. Loss of supraspinal control of all sympathetic preganglionic neurons reduced cardiac sympathetic and parasympathetic tonus, reflex and stress-induced sympathetic responses, and sympathetic support of blood pressure as well as enhanced reliance on angiotensin to maintain arterial blood pressure. Histological examination supports the distinct deficits associated with cervical cord injury.

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