scholarly journals Platelet Count and Prothrombin Time Help Distinguish Thrombotic Thrombocytopenic Purpura–Hemolytic Uremic Syndrome From Disseminated Intravascular Coagulation in Adults

2010 ◽  
Vol 133 (3) ◽  
pp. 460-465 ◽  
Author(s):  
Yara A. Park ◽  
Michael R. Waldrum ◽  
Marisa B. Marques
Keyword(s):  
Platelet Count ◽  
Hemolytic Uremic Syndrome ◽  
Prothrombin Time ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Disseminated Intravascular Coagulation ◽  
Thrombocytopenic Purpura ◽  
Intravascular Coagulation ◽  
Uremic Syndrome

Circulating “Empty” Platelets In Hemolytic Uremic Syndrome And Thrombotic Thrombocytopenic Purpura

1981 ◽  
Author(s):  
G Lüchters ◽  
U Budde ◽  
U Klehr ◽  
N Müller
Keyword(s):  
Platelet Count ◽  
Platelet Aggregation ◽  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Atp Secretion ◽  
Uremic Syndrome ◽  
Platelet Spreading ◽  
Induced Aggregation ◽  
Small Aggregation

In two patients (1 male, 1 female) the diagnosis of hemolytic uremic syndrome (HUS) and in one male patient the diagnosis of thrombotic thrombocytopenic purpura (TTP) was confirmed. All patients showed a platelet aggregating factor in plasma. PgI2-stimulating activity of patient’s plasma was defective or absent. Platelet count was low and platelet aggregation was severely impaired. Even with high amounts of ADP (20 μM) only first phase aggregation could be seen. Epinephrine induced aggregation was absent. The highest amount of collagen used (20 μg/ml) induced only a small aggregation and no ATP-secretion. Thrombin stimulated ATP-secretion was decreased while Ristocetin induced aggregation was normal. ATP- and ADP-content of platelets was low and ATP/ADP ratio was raised above the normal value. Platelet spreading was severely impaired.From these findings we conclude that at least part of the platelets in these related diseases are circulating “empty” platelets which underwent degranulation in the patient’s blood vessels.

scholarly journals Two novel ADAMTS13 gene mutations in thrombotic thrombocytopenic purpura/hemolytic-uremic syndrome (TTP/HUS)

2004 ◽  
Vol 66 (3) ◽  
pp. 955-958 ◽  
Author(s):  
Christoph Licht ◽  
Ludwig Stapenhorst ◽  
Thorsten Simon ◽  
Ulrich Budde ◽  
Reinhard Schneppenheim ◽  
...  
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Gene Mutations ◽  
Thrombocytopenic Purpura ◽  
Uremic Syndrome

The Japanese experience with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome

2004 ◽  
Vol 41 (1) ◽  
pp. 68-74 ◽  
Author(s):  
Masanori Matsumoto ◽  
Hideo Yagi ◽  
Hiromichi Ishizashi ◽  
Hideo Wada ◽  
Yoshihiro Fujimura
Keyword(s):  
Hemolytic Uremic Syndrome ◽  
Thrombotic Thrombocytopenic Purpura ◽  
Thrombocytopenic Purpura ◽  
Japanese Experience ◽  
Uremic Syndrome
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