scholarly journals Haff disease – are we threatened with another epidemic?

2021 ◽  
Author(s):  
Przemysław Paul ◽  
Katarzyna Kanclerz ◽  
Alicja Kubanek ◽  
Andrzej Bałasz ◽  
Marcin Renke
Keyword(s):  
Haff Disease

scholarly journals A Retrospective Analysis of Crayfish-Related Rhabdomyolysis (Haff Disease)

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Changbao Huang ◽  
Liangfei Peng ◽  
Nengkai Gong ◽  
Cheng Xue ◽  
Weihua Wang ◽  
...  
Keyword(s):  
Clinical Data ◽  
Disease Onset ◽  
Clinical Signs ◽  
Signs And Symptoms ◽  
Unknown Etiology ◽  
Chest Tightness ◽  
Presenting Symptoms ◽  
Clinical Signs And Symptoms ◽  
Haff Disease ◽  
Peak Value

Objective. To investigate the epidemiologic and etiologic factors, clinical features, therapeutic regimen, and prognosis of crayfish-related rhabdomyolysis (Haff disease). Methods. Retrospectively analyzed the clinical data of 29 patients with crayfish-related rhabdomyolysis (Haff disease) from July to August 2016, summarized the clinical characteristics, and evaluated the prognosis. Results. Clinical data of a total of 29 cases of Haff disease were retrospectively analyzed. The disease onset occurred after consumption of cooked crayfish with the incubation period ranging from 1 h to 48 h. There were no gender differences and significantly elevated CK in the duration with peak value of 41575.0U/L; the median value was 2445.0U/L (range: from 1187.0 U/L to 4722.0 U/L) and there was coincident elevated CK-MB. There was also no hepatorenal damage and transient urinalysis was abnormal. The most common presenting symptoms were myalgia (100%), weakness and numbness (51.7%), chest tightness and chest pain (41.4%), back pain (41.4%), and extremities pain (37.9%). All the patients recovered and no patients died. Conclusions. Crayfish-related rhabdomyolysis (Haff disease) is a kind of a case or cluster of patients present with severe myalgia or weakness of unknown etiology and mechanism disease; however, the clinical signs and symptoms are relatively mild with favorable outcome.

scholarly journals A cluster of patients with rhabdomyolysis after eating crayfish

CJEM ◽  
2017 ◽  
Vol 20 (S2) ◽  
pp. S48-S50 ◽  
Author(s):  
Wen-Xuan Yang ◽  
Kit-Ling Fan ◽  
Ling-Pong Leung
Keyword(s):  
Emergency Department ◽  
Creatine Kinase ◽  
Creatine Kinase Level ◽  
Procambarus Clarkii ◽  
Supportive Treatment ◽  
Worldwide Distribution ◽  
Freshwater Crustacean ◽  
Diet History ◽  
Haff Disease ◽  
Elevated Creatine Kinase Level

AbstractCrayfish or Procambarus clarkii is a freshwater crustacean with worldwide distribution. Tons of crayfish are consumed each year. In this report, four adult patients with rhabdomyolysis after consuming crayfish were described. All of them presented to the emergency department with myalgia. The diagnosis of rhabdomyolysis was supported by an elevated creatine kinase level. All recovered with supportive treatment. The clinical picture of these 4 patients was compatible with Haff disease. Haff disease is a syndrome in which rhabdomyolysis develops subsequent to consumption of certain cooked seafood. Crayfish is a common culprit. Diagnosis depends on obtaining a diet history and creatine kinase level. Most patients recover uneventfully with supportive treatment for rhabdomyolysis.

scholarly journals The Emergence and Epidemiology of Haff Disease in China

Toxins ◽  
2016 ◽  
Vol 8 (12) ◽  
pp. 359 ◽  
Author(s):  
Thomas Chan
Keyword(s):  
Haff Disease

scholarly journals A past Haff disease outbreak associated with eating freshwater pomfret in South China

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Xi Huang ◽  
Yipeng Li ◽  
Qiong Huang ◽  
Junhua Liang ◽  
Chunsui Liang ◽  
...  
Keyword(s):  
South China ◽  
Disease Outbreak ◽  
Haff Disease

scholarly journals Haff disease in the pandemic COVID-19 period in Brazil

2021 ◽  
Vol 10 (14) ◽  
pp. e358101422175
Author(s):  
Gabriella de Almeida Campos ◽  
Sabrina Jurema da Rocha Dantas ◽  
Emanuel Guilherme de Almeida Carvalho ◽  
Rafael Vinicius de Almeida Tabosa ◽  
Elvys Blayne Sales de Souza ◽  
...  
Keyword(s):  
Critical Period ◽  
Coastal Region ◽  
Cross Sectional Study ◽  
Complete Understanding ◽  
Strategic Information ◽  
Cross Sectional ◽  
The North ◽  
Public Data ◽  
Haff Disease

Objective: This study describes and characterize the cases of Haff disease reported in Brazil during the COVID-19 pandemic period. Descriptive and cross-sectional study using public data from the National Center for Strategic Information and Response in Health Surveillance nacional. The Risk Communication number 17 of 09/15/2021 was accessed. The description of suspected cases was extended to all Brazilian states where notifications occurred, from January 1, 2020, to September 15, 2021. There was an increase in cases of Haff's disease in Brazil, from 2020 onwards, with 46 in the Northeast region of Brazil. Eighty-five cases and three deaths were reported between January and September 2021 in the North, Northeast, South and Midwest regions. Most cases occurred in regions of greater heat such as the coastal region of the Northeast and around regions of the Amazon River Basin. A critical period for coping with the SARS-CoV-2 virus pandemic in Brazil, cases of disease of Haff could be reported in various regions of country. Despite the etiological suspicions, studies, and follow-up of the cases, it is still not possible to affirm that the disease is caused by biomolecules of the Palytoxin-Like Toxins group. The possible identification of the responsible toxin(s) will be essential for a complete understanding of the etiopathogenic mechanism of the disease and adequate development of prevention, treatment, and cure measures.

Haff Disease After Eating Salmon

2007 ◽  
Vol 100 (11) ◽  
pp. 1147-1150 ◽  
Author(s):  
Ricky L. Langley ◽  
William H. Bobbitt
Keyword(s):  
Haff Disease

scholarly journals Ionophore Toxin Maduramicin Produces Haff Disease-Like Rhabdomyolysis in a Mouse Model

2020 ◽  
Vol 17 (21) ◽  
pp. 7882 ◽  
Author(s):  
Xiuge Gao ◽  
Xinhao Song ◽  
Runan Zuo ◽  
Dan Yang ◽  
Chunlei Ji ◽  
...  
Keyword(s):  
Body Weight ◽  
Mouse Model ◽  
Aquatic Environment ◽  
Histopathological Examination ◽  
Feed Consumption ◽  
Exposure Group ◽  
Crayfish Muscle ◽  
Blood Biochemical ◽  
Tissue Homogenates ◽  
Haff Disease

Maduramicin is a toxic ionophore antibiotic that is isolated from Streptomyces, frequently occurring in an aquatic environment. To understand the potential role of maduramicin in crayfish consumption related Haff disease, a mouse model was established in this study. Two exposure routes of maduramicin in the abdominal muscle and the hepatopancreas tissue homogenates of crayfish were given intragastrically to mice in different doses for seven days. Action changes, clinical symptoms, feed consumption, body weight, blood biochemistry, and histopathology examination of mice were observed and analyzed. In the natural exposure group, relatively low concentration of maduramicin in crayfish muscle and hepatopancreas had no obvious effects on mental state, body weight, blood biochemical indexes, or histologic appearance. However, in the artificial exposure group, with increasing concentrations, maduramicin in crayfish muscle and hepatopancreas homogenates both induced mental sluggishness and weight loss of mice. Blood biochemical examination showed that 3.5 mg·kg−1 and 7 mg·kg−1 maduramicin in crayfish tissue homogenates significantly increased levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood urea nitrogen (BUN), lactate dehydrogenase (LDH), and creatine kinase (CK). Additionally, histopathological examination showed that multiple organs were damaged by maduramicin, including degeneration of liver cells, shedding of renal epithelial cells, and disturbance and partial lysis of myocardial and skeletal muscle filaments in the mice. In summary, maduramicin may not cause Haff disease through contamination of the aquatic environment under normal conditions. Maduramicin can be used as a potential toxin tool to establish a rhabdomyolysis disease animal model for drug development.

An Outbreak of Crayfish-Related Haff Disease in the Jiangsu Province of China: A Focus on the Metabolites

2018 ◽  
Author(s):  
Tingwei Wang ◽  
Xufeng Chen ◽  
Lei Jiang ◽  
Peipei Huang ◽  
Hang Xiao ◽  
...  
Keyword(s):  
Jiangsu Province ◽  
Haff Disease

scholarly journals Haff Disease: Rhabdomyolysis After Eating Buffalo Fish

2014 ◽  
Vol 15 (6) ◽  
pp. 664-666 ◽  
Author(s):  
Linda Herman ◽  
Christine Bies
Keyword(s):  
Haff Disease
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