scholarly journals Recommendations for performing specific inhalation challenge tests: Polish experience in relation to the European Respiratory Society guideliness

2020 ◽  
Vol 71 (3) ◽  
pp. 381-397
Author(s):  
Jolanta Walusiak-Skorupa ◽  
Agnieszka Lipinska-Ojrzanowska ◽  
Marta Wiszniewska
Keyword(s):  
European Respiratory Society ◽  
Specific Inhalation Challenge ◽  
Polish Experience ◽  
Challenge Tests ◽  
Inhalation Challenge

scholarly journals Do laboratory challenge tests for occupational asthma represent what happens in the workplace?

2018 ◽  
Vol 51 (6) ◽  
pp. 1800059 ◽  
Author(s):  
P. Sherwood Burge ◽  
Vicky C. Moore ◽  
Alastair S. Robertson ◽  
Gareth I. Walters
Keyword(s):  
Occupational Asthma ◽  
Occupational Exposures ◽  
Reference Standard ◽  
Early Recovery ◽  
Work Related ◽  
Specific Inhalation Challenge ◽  
Challenge Tests ◽  
Delayed Recovery ◽  
Occupational Work ◽  
Inhalation Challenge

Specific inhalation challenge (SIC) is the diagnostic reference standard for occupational asthma; however, a positive test cannot be considered truly significant unless it can be reproduced by usual work exposures. We have compared the timing and responses during SIC in hospital to Oasys analysis of serial peak expiratory flow (PEF) during usual work exposures.All workers with a positive SIC to occupational agents between 2006 and 2015 were asked to measure PEF every 2 h from waking to sleeping for 4 weeks during usual occupational exposures. Responses were compared between the laboratory challenge and the real-world exposures at work.All 53 workers with positive SIC were included. 49 out of 53 had records suitable for Oasys analysis, 14 required more than one attempt and all confirmed occupational work-related changes in PEF. Immediate SIC reactors and deterioration within the first 2 h of starting work were significantly correlated with early recovery, and late SIC reactors and a delayed start to workplace deterioration were significantly correlated with delayed recovery. Dual SIC reactions had features of immediate or late SIC reactions at work rather than dual reactions.The concordance of timings of reactions during SIC and at work provides further validation for the clinical significance of each test.

scholarly journals Pulmonary Function Testing in Work-Related Asthma: An Overview from Spirometry to Specific Inhalation Challenge

2021 ◽  
Vol 18 (5) ◽  
pp. 2325
Author(s):  
Mathias Poussel ◽  
Isabelle Thaon ◽  
Emmanuelle Penven ◽  
Angelica I. Tiotiu
Keyword(s):  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Objective Evaluation ◽  
Pulmonary Function Testing ◽  
Initial Assessment ◽  
Work Related ◽  
Specific Inhalation Challenge ◽  
Occupational Setting ◽  
Inhalation Challenge ◽  
Function Testing

Work-related asthma (WRA) is a very frequent condition in the occupational setting, and refers either to asthma induced (occupational asthma, OA) or worsened (work-exacerbated asthma, WEA) by exposure to allergens (or other sensitizing agents) or to irritant agents at work. Diagnosis of WRA is frequently missed and should take into account clinical features and objective evaluation of lung function. The aim of this overview on pulmonary function testing in the field of WRA is to summarize the different available tests that should be considered in order to accurately diagnose WRA. When WRA is suspected, initial assessment should be carried out with spirometry and bronchodilator responsiveness testing coupled with first-step bronchial provocation testing to assess non-specific bronchial hyper-responsiveness (NSBHR). Further investigations should then refer to specialists with specific functional respiratory tests aiming to consolidate WRA diagnosis and helping to differentiate OA from WEA. Serial peak expiratory flow (PEF) with calculation of the occupation asthma system (OASYS) score as well as serial NSBHR challenge during the working period compared to the off work period are highly informative in the management of WRA. Finally, specific inhalation challenge (SIC) is considered as the reference standard and represents the best way to confirm the specific cause of WRA. Overall, clinicians should be aware that all pulmonary function tests should be standardized in accordance with current guidelines.

Cough variant asthma: A case study with antigen, histamine and methacholine inhalation challenge tests

1994 ◽  
Vol 36 (2) ◽  
pp. 223-226
Author(s):  
A. MORIKAWA ◽  
M. MITSUHASHI ◽  
H. TABATA ◽  
Y. SEKI ◽  
H. MOCHIZUKI ◽  
...  
Keyword(s):  
Cough Variant Asthma ◽  
Challenge Tests ◽  
Inhalation Challenge

Specific Inhalation Challenge in Persulfate Asthma

2015 ◽  
pp. 85-91 ◽  
Author(s):  
O. Hagemeyer ◽  
E. Marek ◽  
V. van Kampen ◽  
I. Sander ◽  
M. Raulf ◽  
...  
Keyword(s):  
Specific Inhalation Challenge ◽  
Inhalation Challenge

scholarly journals 1512 Asthma control and work disability in subjects previously evaluated for work-related asthma with specific inhalation challenge

2018 ◽  
Author(s):  
Ilenia Folletti ◽  
Umberto Giovannelli ◽  
Giulia Paolocci ◽  
Marco dell’Omo ◽  
Angela Gambelunghe ◽  
...  
Keyword(s):  
Asthma Control ◽  
Work Disability ◽  
Work Related ◽  
Specific Inhalation Challenge ◽  
Inhalation Challenge

Can persulfates cause hypersensitivity pneumonitis? A report of specific inhalation challenge test in 42 hairdressers

2020 ◽  
Author(s):  
Jens-Tore Granslo ◽  
Jorunn Kirkeleit ◽  
Stein Håkon Låstad Lygre ◽  
William Horsnell ◽  
Thomas Blix Grydeland ◽  
...  
Keyword(s):  
Hypersensitivity Pneumonitis ◽  
Challenge Test ◽  
Specific Inhalation Challenge ◽  
Inhalation Challenge
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