Blood pressure variations are not predictive for survival length in Multiple Systems Atrophy

Research ◽  
2015 ◽  
Vol 2 ◽  
Author(s):  
A Fisher ◽  
L Merkin ◽  
A Rozenberg ◽  
D Klepikov ◽  
T Gurevich
Keyword(s):  
Blood Pressure ◽  
Multiple Systems ◽  
Multiple Systems Atrophy

Blood pressure variations are not predictive for survival length in multiple systems atrophy

2015 ◽  
Vol 357 ◽  
pp. e268
Author(s):  
T. Gurevich ◽  
A. Fisher ◽  
L. Merkin ◽  
A. Rozenberg ◽  
N. Giladi
Keyword(s):  
Blood Pressure ◽  
Multiple Systems ◽  
Multiple Systems Atrophy

Movement Disorders 2: Parkinson’s Plus and Degenerative Diseases (DRAFT)

2018 ◽  
Author(s):  
Tamara Kaplan ◽  
Tracey Milligan
Keyword(s):  
Huntington's Disease ◽  
Progressive Supranuclear Palsy ◽  
Movement Disorders ◽  
Dementia With Lewy Bodies ◽  
Wilson’S Disease ◽  
Lewy Bodies ◽  
Corticobasal Degeneration ◽  
Degenerative Diseases ◽  
Multiple Systems ◽  
Multiple Systems Atrophy

The video in this chapter explores movement disorders, and focuses on Parkinson’s Plus and degenerative diseases. It outlines the features and pathology of dementia with lewy bodies (DLB), progressive supranuclear palsy (PSP), multiple systems atrophy (MSA) and corticobasal degeneration (CBD), as well as genetic movement disorders, Wilson’s disease, and Huntington’s disease.

scholarly journals Force Control Deficits in Individuals with Parkinson’s Disease, Multiple Systems Atrophy, and Progressive Supranuclear Palsy

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58403 ◽  
Author(s):  
Kristina A. Neely ◽  
Peggy J. Planetta ◽  
Janey Prodoehl ◽  
Daniel M. Corcos ◽  
Cynthia L. Comella ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Progressive Supranuclear Palsy ◽  
Force Control ◽  
Multiple Systems ◽  
Multiple Systems Atrophy

scholarly journals Differentiating clinical examinations of Parkinson’s and parkisonisms

2021 ◽  
Author(s):  
Fernanda Cristina Poscai Ribeiro ◽  
Everton Lopes Rodrigues
Keyword(s):  
Multiple System Atrophy ◽  
Corticobasal Degeneration ◽  
Accurate Diagnosis ◽  
The Body ◽  
Ocular Motility ◽  
Clinical Tests ◽  
Vertical Movements ◽  
Multiple Systems ◽  
Multiple Systems Atrophy ◽  
Romberg Test

Introduction: The main symptoms of Parkinson are: tremors, movement resistance, postural instability and bradykinesia. However, other diseases such as Progressive Supranuclear Paralysis, Multiple System Atrophy and Corticobasal Degeneration have similar symptoms. This similarity generates a difficulty of diagnosis, for example, Corticobasal Degeneration is often diagnosed by autopsy. Objectives: To define the differentiating symptoms of Parkinson and the diseases mentioned and to find clinical tests that could aid in the diagnosis. Methodology: The integrative review utilized Scielo and Pubmed databases and the selected clinical examinations were obtained by the book Exame Clinico - 8° edition. Results: Multiple Systems Atrophy is distinguished from Parkinson by occurrence of cerebelar abnormalities, therefore Romberg Test can evidence modified coordination, which may be indicative of Multiple System Atrophy. Corticobasal Degeneration causes loss of ability to identify things by touch and impaired sensitivity on one side of the body, thereby the verification of stereognosia and the examination of superficial sensitivity are useful. Supranuclear Paralysis Progressive generates difficulty of performing vertical movements, thus the examination of ocular motility is necessary. Conclusion: Only clinical examinations aren’t sufficient to generate an accurate diagnosis and complementary exams are necessary for greater precision. However, knowledge about differentiating clinical examinations helps to generate a line of reasoning and examinations to be requested.

scholarly journals In situ architecture of neuronal α-Synuclein inclusions

2020 ◽  
Author(s):  
Victoria A. Trinkaus ◽  
Irene Riera-Tur ◽  
Antonio Martínez-Sánchez ◽  
Felix J.B. Bäuerlein ◽  
Qiang Guo ◽  
...  
Keyword(s):  
Amyloid Fibrils ◽  
Electron Tomography ◽  
Structural Flexibility ◽  
Multiple Systems ◽  
Cryo Electron Tomography ◽  
Multiple Systems Atrophy ◽  
The Brain ◽  
Cellular Organelles

Summaryα-Synuclein (α-Syn) aggregation is a hallmark of devastating neurodegenerative disorders including Parkinson’s disease (PD) and multiple systems atrophy (MSA)1,2. α-Syn aggregates spread throughout the brain during disease progression2, suggesting mechanisms of intercellular seeding. Formation of α-Syn amyloid fibrils is observed in vitro3,4 and fibrillar α-Syn has been purified from patient brains5,6, but recent reports questioned whether disease-relevant α-Syn aggregates are fibrillar in structure7-9. Here we use cryo-electron tomography (cryo-ET) to image neuronal Lewy body-like α-Syn inclusions in situ at molecular resolution. We show that the inclusions consist of α-Syn fibrils crisscrossing a variety of cellular organelles such as the endoplasmic reticulum (ER), mitochondria and autophagic structures, without interacting with membranes directly. Neuronal inclusions seeded by recombinant or MSA patient-derived α-Syn aggregates have overall similar architecture, although MSA-seeded fibrils show higher structural flexibility. Using gold-labeled seeds we find that aggregate nucleation is predominantly mediated by α-Syn oligomers, with fibrils growing unidirectionally from the seed. Our results conclusively demonstrate that neuronal α-Syn inclusions contain α-Syn fibrils intermixed with cellular membranes, and illuminate the mechanism of aggregate nucleation.

Amyloid and glucose imaging in dementia with Lewy bodies and multiple systems atrophy

2011 ◽  
Vol 17 (3) ◽  
pp. 160-165 ◽  
Author(s):  
Daniel O. Claassen ◽  
Val J. Lowe ◽  
Patrick J. Peller ◽  
Ronald C. Petersen ◽  
Keith A. Josephs
Keyword(s):  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Multiple Systems ◽  
Multiple Systems Atrophy

RFC1 Intronic Repeat Expansions Absent in Pathologically Confirmed Multiple Systems Atrophy

2020 ◽  
Vol 35 (7) ◽  
pp. 1277-1279 ◽  
Author(s):  
Roisin Sullivan ◽  
Wai Yan Yau ◽  
Viorica Chelban ◽  
Salvatore Rossi ◽  
E. O'Connor ◽  
...  
Keyword(s):  
Multiple Systems ◽  
Repeat Expansions ◽  
Multiple Systems Atrophy

scholarly journals Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated

2019 ◽  
Vol 28 (R2) ◽  
pp. R151-R161 ◽  
Author(s):  
Claudia P Cabrera ◽  
Fu Liang Ng ◽  
Hannah L Nicholls ◽  
Ajay Gupta ◽  
Michael R Barnes ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Molecular Mechanisms ◽  
Association Studies ◽  
Drug Repurposing ◽  
Complex Trait ◽  
Genome Wide Association Studies ◽  
Genetic Associations ◽  
Genetic Loci ◽  
Multiple Systems ◽  
Environmental Interactions

Abstract High blood pressure (BP) remains the major heritable and modifiable risk factor for cardiovascular disease. Persistent high BP, or hypertension, is a complex trait with both genetic and environmental interactions. Despite swift advances in genomics, translating new discoveries to further our understanding of the underlying molecular mechanisms remains a challenge. More than 500 loci implicated in the regulation of BP have been revealed by genome-wide association studies (GWAS) in 2018 alone, taking the total number of BP genetic loci to over 1000. Even with the large number of loci now associated to BP, the genetic variance explained by all loci together remains low (~5.7%). These genetic associations have elucidated mechanisms and pathways regulating BP, highlighting potential new therapeutic and drug repurposing targets. A large proportion of the BP loci were discovered and reported simultaneously by multiple research groups, creating a knowledge gap, where the reported loci to date have not been investigated in a harmonious way. Here, we review the BP-associated genetic variants reported across GWAS studies and investigate their potential impact on the biological systems using in silico enrichment analyses for pathways, tissues, gene ontology and genetic pleiotropy.

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