scholarly journals A Study on Single Dose Toxicity of Intravenous Injection of Mecasin Herbal Acupuncture

2016 ◽  
Vol 33 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Seong Jin Lee ◽  
Ho Hyun Jeong ◽  
Jong Chul Lee ◽  
Eun Hye Cha ◽  
Man Yong Park ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Injection

scholarly journals Intravenous injection of cyclophilin A realizes the transient and reversible opening of barrier of neural vasculature through basigin in endothelial cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Narumi Nakada-Honda ◽  
Dan Cui ◽  
Satoshi Matsuda ◽  
Eiji Ikeda
Keyword(s):  
Endothelial Cells ◽  
Single Dose ◽  
Blood Brain Barrier ◽  
Intravenous Injection ◽  
Cyclophilin A ◽  
Brain Barrier ◽  
Blood Brain ◽  
Neural Tissues ◽  
Neural Diseases

AbstractNeural vasculature forms the blood–brain barrier against the delivery of systemically administered therapeutic drugs into parenchyma of neural tissues. Therefore, procedures to open the blood–brain barrier with minimal damage to tissues would lead to the great progress in therapeutic strategy for intractable neural diseases. In this study, through analyses with mouse in vitro brain microvascular endothelial cells and in vivo neural vasculature, we demonstrate that the administration of cyclophilin A (CypA), a ligand of basigin which is expressed in barrier-forming endothelial cells, realizes the artificial opening of blood–brain barrier. Monolayers of endothelial cells lost their barrier properties through the disappearance of claudin-5, an integral tight junction molecule, from cell membranes in a transient and reversible manner. Furthermore, the intravenous injection of a single dose of CypA into mice resulted in the opening of blood–brain barrier for a certain period which enabled the enhanced delivery of systemically administered doxorubicin into the parenchyma of neural tissues. These findings that the pre-injection of a single dose of CypA realizes an artificial, transient as well as reversible opening of blood–brain barrier are considered to be a great step toward the establishment of therapeutic protocols to overcome the intractability of neural diseases.

scholarly journals Distribution of selenium in sheep treated with dipheny diselenide

2018 ◽  
Vol 70 (4) ◽  
pp. 1017-1022
Author(s):  
M.L.R. Leal ◽  
J.B.T. Rocha ◽  
C.L.D. Corte ◽  
A.R. Aires ◽  
J.F.X. Rocha ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Single Dose ◽  
Intravenous Injection ◽  
Selenium Concentration ◽  
Treated Group ◽  
Post Treatment ◽  
Control Group ◽  
Diphenyl Diselenide ◽  
Single Intravenous Injection

ABSTRACT The aim of the present study was to report the in vivo distribution of selenium in sheep. For this, animals were allocated into two groups (control group and treated group) and kept in metabolic cages for a period of 37 days. The treated group received a single dose (6µmol/kg) of Diphenyl Diselenide, intravenously. Plasma and erythrocytes samples were collected at different times. Adipose tissue, muscles (latissimusdorsi, semitendinosus, and supra-scapular) heart, liver, lung, kidney, intestine and brain were sampled at 30 days post-treatment, in order to determine the selenium concentration. The results demonstrated that the selenium, from the Diphenyl Diselenide group, was higher in erythrocytes (4.8mg/L, six hours post-treatment) when compared with the control sheep. The deposition of selenium occurred in the liver (7.01µg/g), brain (3.53µg/g) and kidney (2.02µg/g). After 30 days of a single intravenous injection of Diphenyl Diselenide, liver was the main organ of selenium deposition.

HPLC Method for Detection of Ergotamine, Ergosine, and Ergine after Intravenous Injection of a Single Dose

1996 ◽  
Vol 44 (1) ◽  
pp. 146-148 ◽  
Author(s):  
Ali S. Moubarak ◽  
Edgar L. Piper ◽  
Zelpha B. Johnson ◽  
Miroslav Flieger
Keyword(s):  
Single Dose ◽  
Intravenous Injection ◽  
Hplc Method

scholarly journals PRECIPITIN RESPONSE IN THE BLOOD OF RABBITS FOLLOWING SUBARACHNOID INJECTIONS OF HORSE SERUM

1921 ◽  
Vol 33 (4) ◽  
pp. 471-484 ◽  
Author(s):  
Harry L. Alexander
Keyword(s):  
Single Dose ◽  
Intravenous Injection ◽  
Subarachnoid Space ◽  
High Titer ◽  
Horse Serum ◽  
Passive Transfer ◽  
Normal Horse Serum ◽  
Initial Injection

1. Rabbits which have received a single dose of normal horse serum in the subarachnoid space produce precipitins in the blood in greater abundance, of higher titer, and persisting longer than those in control rabbits which have received a similar injection intravenously. 2. Repeated subarachnoid injections of normal horse serum in rabbits induce precipitins in the blood early. These may appear in high titer as soon as 1 week after the initial injection, whereas in rabbits similarly treated intravenously no precipitins are found at this time. They may appear a few days afterward and reach a high titer. 3. No anaphylactic manifestations occurred in rabbits treated repeatedly with subarachnoid injections of normal horse serum when the precipitin content of the blood was high. 4. Anaphylactins, as determined by passive transfer of anaphylaxis, were demonstrated in sera with high precipitin content. 5. These experiments may explain clinical evidences of anaphylaxis, observed when an initial intravenous injection of horse serum followed a series of intraspinal injections of such serum.

scholarly journals Single-dose Toxicity of Guseonwangdo-go Glucose 20% Intravenous Injection in Sprague-Dawley Rats

2014 ◽  
Vol 17 (3) ◽  
pp. 25-30 ◽  
Author(s):  
Yu-jong Kim ◽  
Su-jeong Jo ◽  
Young-doo Choi ◽  
Eun-jung Kim ◽  
Kap-sung Kim ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Injection ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals THE RÔLE OF THE RETICULO-ENDOTHELIAL SYSTEM IN IMMUNITY

1930 ◽  
Vol 51 (1) ◽  
pp. 5-14 ◽  
Author(s):  
Claus W. Jungeblut ◽  
Barbara R. McGinn
Keyword(s):  
Single Dose ◽  
Intravenous Injection ◽  
Guinea Pigs ◽  
Single Injection ◽  
Arsenic Content ◽  
Experimental Conditions ◽  
Normal Organ ◽  
India Ink ◽  
Normal Controls ◽  
Reticulo Endothelial System

1. Blockade of the reticulo-endothelial system by means of a single injection of India ink caused a marked retention of neoarsphenamine in the blood of guinea pigs during the first twenty minutes of observation after intravenous injection, as contrasted with the rapid disappearance of the drug from the blood of normal controls. 2. Rabbits blocked by a single dose of India ink showed a slower elimination of the drug from the circulation following the first few hours after intravenous injection than corresponding controls. 3. The arsenic content of the liver of mice, which received neoarsphenamine intravenously after a preceding blocking injection with India ink, was appreciably lower than the arsenic content of the normal organ under similar experimental conditions.

scholarly journals Single-dose Toxicity of Guseonwangdo-go Glucose 5% Intravenous Injection in a Rat Model

2015 ◽  
Vol 18 (3) ◽  
pp. 57-62
Author(s):  
Seung-deok Lee ◽  
Su-jeong Jo ◽  
Young-doo Choi ◽  
Chan-yung Jung ◽  
Kap-sung Kim
Keyword(s):  
Single Dose ◽  
Intravenous Injection ◽  
Rat Model

scholarly journals The Appearance of Labeled Cells in the Thoracic Duct Lymph of the Guinea Pig after the Administration of Tritiated Thymidine

Blood ◽  
1960 ◽  
Vol 15 (1) ◽  
pp. 82-94 ◽  
Author(s):  
N. B. EVERETT ◽  
W. O. REINHARDT ◽  
J. M. YOFFEY
Keyword(s):  
Single Dose ◽  
Guinea Pig ◽  
Intravenous Injection ◽  
Thoracic Duct ◽  
Guinea Pigs ◽  
Tritiated Thymidine ◽  
Thoracic Duct Lymph ◽  
Duct Lymph ◽  
Cell Series ◽  
Sequential Appearance

Abstract Tritium-labeled thymidine was given by either intraperitoneal or intravenous injection to 13 male guinea pigs of approximately 400 Gm. weight. At times varying from 1 hour to 30 days after the administration of thymidine, thoracic duct lymph was obtained and examined for the presence of labeled cells. After a single dose of thymidine, a steady stream of labeled lymphocytes, ranging from 2 to 7 per cent of the total cells, enters the blood over the period studied. The intensity of the labeling appears to diminish gradually. Labeled large and medium lymphocytes were found in the lymph during the first hour. Labeled small lymphocytes began to appear in the fourth hour, in small numbers, and thereafter increased, whereas the proportion of labeled large and medium lymphocytes steadily diminished. This sequential appearance of large, medium and small lymphocytes is interpreted as indicating the pattern of development of the cell series. The labeled small lymphocytes appearing in the lymph are considered to be newly formed from precursor cells located in the various lymphatic tissues.

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