Effect of nano-sized iron overload with ascorbic acid on the formation of colonic pre-neoplastic lesions in mice

2016 ◽  
Vol 40 (3) ◽  
pp. 83-89 ◽  
Author(s):  
Jong-Hwi Park ◽  
◽  
Sung-June Kim ◽  
Jae-Hwang Jeong ◽  
Sang Yoon Nam ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Iron Overload ◽  
Neoplastic Lesions

scholarly journals Effects of Iron Overload on Ascorbic Acid Metabolism

BMJ ◽  
1968 ◽  
Vol 3 (5620) ◽  
pp. 704-707 ◽  
Author(s):  
A. A. Wapnick ◽  
S. R. Lynch ◽  
P. Krawitz ◽  
H. C. Seftel ◽  
R. W. Charlton ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Iron Overload ◽  
Acid Metabolism

scholarly journals The effect of siderosis and ascorbic acid depletion on bone metabolism, with special reference to osteoporosis in the Bantu

1971 ◽  
Vol 25 (3) ◽  
pp. 367-376 ◽  
Author(s):  
A. A. Wapnick ◽  
S. R. Lynch ◽  
H. C. Seftel ◽  
R. W. Charlton ◽  
T. H. Bothwell ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Bone Resorption ◽  
Bone Formation ◽  
Iron Overload ◽  
Bone Mineral ◽  
Guinea Pigs ◽  
Iron Concentration ◽  
Ascorbic Acid Deficiency ◽  
Acid Deficiency ◽  
Liver Storage

1. There is an association between iron overload, ascorbic acid deficiency and osteoporosis in middle-aged South African Bantu males. The iron overload contributes to the ascorbic acid deficiency by accelerating its oxidative catabolism. The object of the present investigation was to explore the possibility that the osteoporosis results from chronic ascorbic acid deficiency.2. On quantitative microradiography, percentage bone-formation surface was normal but percentage bone-resorption surface was significantly increased in ten osteoporotic subjects compared with seven control subjects.3. There was a significant inverse correlation between bone mineral density and liver storage iron concentration in thirty-five Bantu subjects. In thirteen individuals aged 39 years or less, liver storage iron concentration was significantly correlated with percentage bone-resorption surface.4. Guinea-pigs deprived of ascorbic acid for 21 d exhibited both significantly diminished percentage bone-formation surface and increased percentage bone-resorption surface.5. Guinea-pigs overloaded with iron by injections of iron dextran developed significantly reduced hepatic ascorbic acid concentrations and bone mineral densities; percentage bone-formation surface was significantly diminished and percentage bone-resorption surface significantly increased. Ascorbic acid injection largely prevented the bone changes.

Effect of iron overload with ascorbic acid on experimental colon carcinogenesis in mice

2017 ◽  
Vol 18 (4) ◽  
pp. 136-141
Author(s):  
Tae-Hyon Ahn ◽  
Sung-June Kim ◽  
Jae-Hwang Jeong ◽  
Sang Yoon Nam ◽  
Young Won Yun ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Iron Overload ◽  
Colon Carcinogenesis

Promotion by ascorbic acid, sodium erythorbate and ethoxyquin of neoplastic lesions in rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine

1984 ◽  
Vol 23 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Shoji Fukushima ◽  
Yasushi Kurata ◽  
Masa-Aki Shibata ◽  
Etsuo Ikawa ◽  
Nobuyuki Ito
Keyword(s):  
Ascorbic Acid ◽  
Neoplastic Lesions

High-dose Vitamin C: A Risk for Persons with High Iron Stores?

1999 ◽  
Vol 69 (2) ◽  
pp. 67-82 ◽  
Author(s):  
Gerster
Keyword(s):  
Ascorbic Acid ◽  
Vitamin C ◽  
Iron Overload ◽  
Deficiency Anemia ◽  
High Dose ◽  
Iron Stores ◽  
High Iron ◽  
Increased Risk ◽  
And Storage ◽  
High Dose Vitamin

The contribution of vitamin C (ascorbic acid) to the prevention of iron deficiency anemia by promoting the absorption of dietary non-heme iron – especially in persons with low iron stores – is well established. But the question has been raised whether high-dose intakes of vitamin C might unduly enhance the absorption of dietary iron in persons with high iron stores or in patients with iron overload, possibly increasing the potential risk of iron toxicity. Extensive studies have shown that overall the uptake and storage of iron in humans is efficiently controlled by a network of regulatory mechanisms. Even high vitamin C intakes do not cause iron imbalance in healthy persons and probably in persons who are heterozygous for hemochromatosis. The uptake, renal tubular reabsorption and storage of vitamin C itself are also strictly limited after high-dose intake so that no excessive plasma and tissue concentrations of vitamin C are produced. The effect of high-dose vitamin C on iron absorption in patients with iron overload due to homozygous hemochromatosis has not been studied. Of special importance is the early identification of hemochromatosis patients, which is assisted by the newly developed PCR test for hereditary hemochromatosis. Specific treatment consists of regular phlebotomy and possibly iron-chelating therapy. These patients should moreover avoid any possibility of facilitated absorption of iron and need to limit their intake of iron. Patients with beta-thalassemia major and sickle cell anemia who suffer from iron overload due to regular blood transfusions or excessive destruction of red blood cells need specialized medical treatment with iron chelators and should also control their intake of iron. The serum of patients with pathological iron overload can contain non-transferrin-bound iron inducinglipid peroxidation with subsequent consumption of antioxidants such as vitamin E and vitamin C. The role of iron in coronary heart disease and cancer is controversial. Early suggestions that moderately elevated iron stores are associated with an increased risk of CHD have not been confirmed by later studies. In vitro, ascorbic acid can act as a prooxidant in the presence of transition metals such as iron or copper, but in the living organism its major functions are as an antioxidant. High intakes of vitamin C have thus not been found to increase oxidative damage in humans. Accordingly, the risk of CHD or cancer is not elevated. On the contrary, most studies have shown that diets rich in vitamin C are inversely related to the incidence of these diseases.

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