scholarly journals Protective role of uric acid against photooxidative stress in the silkworm, Bombyx mori (Lepidoptera : Bombycidae)

1999 ◽  
Vol 34 (4) ◽  
pp. 481-484 ◽  
Author(s):  
Takashi Matsuo ◽  
Yukio Ishikawa
Gene ◽  
2015 ◽  
Vol 567 (2) ◽  
pp. 138-145 ◽  
Author(s):  
Ping Chen ◽  
Jiying Wang ◽  
Haiyin Li ◽  
Yan Li ◽  
Peng Chen ◽  
...  

2014 ◽  
Vol 388 (1) ◽  
pp. 48-56 ◽  
Author(s):  
Takumi Kayukawa ◽  
Mika Murata ◽  
Isao Kobayashi ◽  
Daisuke Muramatsu ◽  
Chieko Okada ◽  
...  

2014 ◽  
Vol 447 (2) ◽  
pp. 237-243 ◽  
Author(s):  
Chun Pan ◽  
Yan-Fen Hu ◽  
Hua-Shan Yi ◽  
Juan Song ◽  
La Wang ◽  
...  

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
Gianmarco Borriello ◽  
Davide Viggiano ◽  
Giovambattista Capasso

Abstract Background and Aims Mild Cognitive Impairment (MCI) has been found to be highly prevalent amongst patients with Chronic Kidney Disease (CKD). In this cohort, the prevalence of MCI was estimated to be between 30% and 63%. Mild cognitive impairment is an intermediate state between normal aging and dementia. An individual suffering from MCI has difficulty in remembering, sustaining attention, or decision making which can negatively affect their daily lives. The aim of this study was to verify the role of different glomerular diseases diagnosed by kidney biopsy on the MCI through a retrospective study. Method We recruited 45 patients with bioptic diagnosis of the following glomerular diseases: Focal Segmental Glomerulo Sclerosis (FSGS), minimal change disease (MCD), membranous glomerular disease (MG), IgA nephropathy. The renal function was analyzed using clinical variables, while Cognitive functions using the MoCA test. Patients were divided into two groups based on 24h proteinuria. Results The MoCA score was directly correlated to the uric acid levels (R=0.13; p=0.03). The MoCa score in the group with higher proteinuria levels was significantly lower than those of the group with lower proteinuria levels (p = 0.03). Finally, the MoCA score in subjects with FSGS or MCD is significantly higher compared the other groups (p<0.05). Conclusion Our data suggest that serum uric acid and proteinuria in glomerular diseases influence cognitive functions. Interestingly, uric acid plays a neuroprotective role, as low levels of uric acid reduce the MoCA score. This result agrees with previous observations of a protective role of uric acid on dopamine neurons. Conversely, the extent proteinuria seems to negatively affect cognitive functions, suggesting a role of the endothelial dysfunction. Finally, glomerulopathies with a lower degree of inflammation (FSGS, MCD) have minor impact on cognitive functions.


2013 ◽  
Vol 13 (125) ◽  
pp. 1-13 ◽  
Author(s):  
Ikuyo Arai ◽  
Masayuki Ohta ◽  
Asahi Suzuki ◽  
Shiho Tanaka ◽  
Yasutaka Yoshizawa ◽  
...  

PLoS ONE ◽  
2017 ◽  
Vol 12 (1) ◽  
pp. e0169404 ◽  
Author(s):  
Rui-ting Chen ◽  
Peng Jiao ◽  
Zhen Liu ◽  
Yan Lu ◽  
Hu-hu Xin ◽  
...  

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