Bile Duct Ligation and Insulin-like Growth Factor-I on the Ischemia-Reperfusion Injury of the Smail Bowel

1997 ◽  
Vol 3 (2) ◽  
pp. 98
Author(s):  
J S Cha ◽  
Myung Duk Lee
Keyword(s):  
Growth Factor ◽  
Bile Duct ◽  
Reperfusion Injury ◽  
Bile Duct Ligation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Duct Ligation ◽  
Growth Factor I

The Effect of Insulin-like Growth Factor-I on Hepatocyte Apoptosis After Bile Duct Ligation in Rat

2006 ◽  
Vol 51 (12) ◽  
pp. 2220-2224 ◽  
Author(s):  
Shyr-Ming Sheen-Chen ◽  
Hsin-Tsung Ho ◽  
Lu Chia-Pei ◽  
Kuo-Sheng Hung ◽  
Hock-Liew Eng
Keyword(s):  
Growth Factor ◽  
Bile Duct ◽  
Bile Duct Ligation ◽  
Insulin Like Growth Factor ◽  
Hepatocyte Apoptosis ◽  
Factor I ◽  
Duct Ligation ◽  
Growth Factor I

353 INSULIN-LIKE GROWTH FACTOR I ENHANCES BILE-DUCT PROLIFERATION AND FIBROSIS IN ABCB4−/− MICE

2012 ◽  
Vol 56 ◽  
pp. S143
Author(s):  
A. Sokolovic ◽  
C.M. Rodriguez-Ortigosa ◽  
L. ten Bloemendaal ◽  
N. Juanarena ◽  
S. Arcelus ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bile Duct ◽  
Insulin Like Growth Factor ◽  
Bile Duct Proliferation ◽  
Factor I ◽  
Growth Factor I

scholarly journals The Impact of a Nitric Oxide Synthase Inhibitor (L-NAME) on Ischemia–Reperfusion Injury of Cholestatic Livers by Pringle Maneuver and Liver Resection after Bile Duct Ligation in Rats

2019 ◽  
Vol 20 (9) ◽  
pp. 2114 ◽  
Author(s):  
Junji Iwasaki ◽  
Mamdouh Afify ◽  
Christian Bleilevens ◽  
Uwe Klinge ◽  
Ralf Weiskirchen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Liver Resection ◽  
Bile Duct ◽  
Bile Duct Ligation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pringle Maneuver ◽  
Endothelial Lining ◽  
Duct Ligation ◽  
Oxide Synthase

The Pringle maneuver (PM) has been widely used to control blood loss during liver resection. However, hepatic inflow occlusion can also result in hepatic ischemia–reperfusion injury (IRI), especially in patients with a cholestatic, fibrotic, or cirrhotic liver. Here we investigate a nitric oxide synthase (NOS) inhibitor N-Nitroarginine methyl ester (L-NAME) on IRI after the PM and partial hepatectomy of cholestatic livers induced by bile duct ligation (BDL) in rats. Control group (non-BDL/no treatment), BDL + T group (BDL/L-NAME treatment) and BDL group (BDL/no treatment) were analyzed. Cholestasis was induced by BDL in the L-NAME and BDL group and a 50% partial hepatectomy with PM was performed. L-NAME was injected before PM in the BDL + T group. Hepatocellular damage, portal venous flow, microcirculation, endothelial lining, and eNOS, iNOS, interleukin (IL)-6, and transforming growth factor-β (TGF-β) were evaluated. Microcirculation of the liver in the BDL + T group tended to be higher. Liver damage and apoptotic index were significantly lower and Ki-67 labeling index was higher in the BDL + T group while iNOS and TGF-β expression was decreased. This was corroborated by a better preserved endothelial lining. L-NAME attenuated IRI following PM and improved proliferation/regeneration of cholestatic livers. These positive effects were considered as the result of improved hepatic microcirculation, prevention of iNOS formation, and TGF-β mRNA upregulation.

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