scholarly journals Pneumothorax Is a Significant Risk Factor for Mortality in Congenital Diaphragmatic Hernia: A Single Center Experience

2018 ◽  
Vol 24 (2) ◽  
pp. 68
Author(s):  
SeungWook Han ◽  
Sanghoon Lee ◽  
Joonhyuk Son ◽  
Jeong-Meen Seo ◽  
Suk-Koo Lee
Author(s):  
Jennifer Bettina Brandt ◽  
Tobias Werther ◽  
Erika Groth ◽  
Erik Küng ◽  
Johann Golej ◽  
...  

Summary Background Despite current progress in research of congenital diaphragmatic hernia, its management remains challenging, requiring an interdisciplinary team for optimal treatment. Objective Aim of the present study was to evaluate potential risk factors for mortality of infants with congenital diaphragmatic hernia. Methods A single-center chart review of all patients treated with congenital diaphragmatic hernia over a period of 16 years, at the Medical University of Vienna, was performed. A comparison of medical parameters between survivors and non-survivors, as well as to published literature was conducted. Results During the observational period 66 patients were diagnosed with congenital diaphragmatic hernia. Overall survival was 84.6%. Left-sided hernia occurred in 51 patients (78.5%) with a mortality of 7.8%. In comparison, right-sided hernia occurred less frequently (n = 12) but showed a higher mortality (33.3%, p = 0.000). Critically instable patients were provided with venoarterial extracorporeal membrane oxygenation (ECMO, 32.3%, n = 21). Survival rate among these patients was 66.7%. Right-sided hernia, treatment with inhaled nitric oxide (iNO) over 15 days and the use of ECMO over 10 days were significant risk factors for mortality. Conclusion The survival rate in this cohort is comparable to the current literature. Parameters such as the side of the diaphragmatic defect, duration of ECMO and inhaled nitric oxide were assessed as mortality risk factors. This analysis of patients with congenital diaphragmatic hernia enhances understanding of risk factors for mortality, helping to improve management and enabling further evaluation in prospective clinical trials.


2018 ◽  
Vol 11 (4) ◽  
pp. 373-377 ◽  
Author(s):  
Masateru Yamamoto ◽  
Yuji Takakura ◽  
Satoshi Ikeda ◽  
Toshiyuki Itamoto ◽  
Takashi Urushihara ◽  
...  

2015 ◽  
Vol 39 (4) ◽  
pp. 241-247 ◽  
Author(s):  
Carmen Mesas Burgos ◽  
Jenny Hammarqvist-Vejde ◽  
Björn Frenckner ◽  
Peter Conner

Objectives: To compare outcomes in pregnancies with a prenatal detection of congenital diaphragmatic hernia (CDH) with children diagnosed after birth, treated at the same institution, and to determine the ability to predict prognosis through measurements of the observed to expected lung-to-head ratio (O/E LHR). Methods: This is a retrospective review of all children with CDH treated at our institution during 2006-2014. We compared outcomes of infants referred for surgery after postnatal diagnosis with outcomes of infants with prenatally diagnosed CDH. Results: In the prenatal group, O/E LHR was significantly different between survivors and deceased patients, with a cutoff at 35% O/E LHR. Survival to discharge and 1-year survival were significantly higher in the postnatal group that required intubation within 24 h; i.e., 92 and 89% versus 85 and 73% in the prenatal group (p < 0.05). There was less need for extracorporeal membrane oxygenation (ECMO), 41 versus 60%, and patch, 41 versus 75% (p < 0.001), in the postnatal group with early diagnosis compared with the prenatal group, respectively. Conclusion: Children with prenatally diagnosed CDH represent a population with a more severe condition compared to infants diagnosed after birth. They have poorer outcomes with higher needs for ECMO or use of patch, and lower survival rates were observed at an O/E LHR below 35%.


2015 ◽  
Vol 26 (04) ◽  
pp. 316-321 ◽  
Author(s):  
Louisa Chiu ◽  
Jagdish Desai ◽  
Christina Shanti ◽  
Sharayu Rane ◽  
Prashant Agarwal ◽  
...  

2015 ◽  
Vol 45 (6) ◽  
pp. 683-688 ◽  
Author(s):  
R. Ruano ◽  
P. Javadian ◽  
J. A. Kailin ◽  
S. A. Maskatia ◽  
A. A. Shamshirsaz ◽  
...  

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