scholarly journals Bio Synthesis of Beta Vulgaris Mediated ZnO Nanoparticles and Their Anti-Bacterial, Anti-Fungal, Anti-Diabetic and Anti-Cancer Activities

2021 ◽  
Vol 37 (4) ◽  
pp. 911-921
Author(s):  
Femina. F ◽  
H. Asia Thabassoom ◽  
S. Auxilia Ruby ◽  
J. Felicita Florence

Plant extract mediated metal or metal oxide nanoparticles is a promising alternate to the chemical and physical methods. Application of nanoparticles in various fields get increased widely due to their properties. Current study involves the eco-friendly method of synthesis and pharmacological applications of zinc oxide nanoparticles (ZnO-NPs) using the aqueous beetroot (Beta vulgaris) extract. Aqueous Beta vulgaris extract has multiple bio-active phytochemicals especially antioxidants like anthocyanins and betacyanins, also reported a rich source of minerals. Synthesized ZnONPs were characterized with the aid of UV-Vis spectroscopy, FTIR, SEM, XRDand EDX. Antibacterial results suggests that, Beta vulgaris mediated ZnONPspossessthe maximum zone of inhibition against Escherichia coli then Staphylococcus aureus. On anti-fungal activity synthesized ZnONPS revealed greater inhibitory effect against Candida albicans fungi than the Aspergillusflavus. Synthesized ZnONPs exhibits the noticeable pharmacological activities against the anti-diabetic and anti-cancer activities (MCF-7 cell line, IC50=35.4µg/ml). This study has suggested an effective replacement for the hazardous chemical methods and lead to a cost-effective, environmentally -friendly method which can also be used as an antimicrobial, anti-diabetic and anti-cancer agents.

Nano Hybrids ◽  
2013 ◽  
Vol 4 ◽  
pp. 61-85
Author(s):  
Mohd Farhan Khan ◽  
Akhter H. Ansari ◽  
M. Hameedullah ◽  
M.B. Lohani ◽  
Mohammad Mezbaul Alam ◽  
...  

Since few decades, the fabrications of metal oxide nanoparticles (MO-Nps) as well as their uses in various segments have been increased manifolds. An easy effort to produce an important category of MO-Nps as Zinc oxide nanoparticles (ZnO-Nps), with the assistance of mechano-solution method at various low temperatures, introducing Zinc acetate dihydrate and Sodium hydroxide into the molar solution of C19H42NBr complex (Cetrimonium bromide, CTAB) for much less than an hour was projected. The impact of this method performed at two different ranges of process temperatures was studied and the magnitude of the ZnO-Nps (like particle size, morphology and L/D dimensions) has been reported. On the top of this, the morphological study of these Nps has been presented. The characterization of the synthesized Nps was carried out with the help of SEM with EDS, XRD, UV-Vis spectroscopy. The scanning electron microscopy has revealed the synthesis of peanut-shaped ZnO nanobunches (NBs) at two different ranges of temperature. An overall viable growth of the solitary nanoparticles constituting of ZnO-NBs has also been put forth. Hence, the effect of temperature on C19H42NBr complex (stabilizer) has been reported. In addition, a postulated model depicting the relationship of the temperature effect on the process parameters of ZnO-NBs has also been floated. The Gram +ve bacteria, Bacillus subtilis is a rod shaped bacteria which is commonly known as normal gut commensal in humans. Due to the emergence of anti-biotic resistant drugs, alternate medications are under primary considerations. A noteworthy experimentation was concerned with anti-bacterial activity of therapeutically viable Gram +ve bacteria, Bacillus subtilis and it was found that reported ZnO-NBs have become the promising entities for terminating the growth of these bacterias.


Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 3025
Author(s):  
Maryam Bayat ◽  
Meisam Zargar ◽  
Tamara Astarkhanova ◽  
Elena Pakina ◽  
Sergey Ladan ◽  
...  

In this investigation, for the first time, we used Fragaria ananassa (strawberry) leaf extract as a source of natural reducing, capping or stabilizing agents to develop an eco-friendly, cost-effective and safe process for the biosynthesis of metal-based nanoparticles including silver, copper, iron, zinc and magnesium oxide. Calcinated and non-calcinated zinc oxide nanoparticles also synthesized during a method different from our previous study. To confirm the successful formation of nanoparticles, different characterization techniques applied. UV-Vis spectroscopy, X-ray Diffraction (XRD) spectroscopy, Field Emission Scanning Electron Microscopy (FESEM) coupled with Energy Dispersive X-ray Spectroscopy (EDS), Photon Cross-Correlation Spectroscopy (PCCS) and Fourier Transformed Infrared Spectroscopy (FT-IR) were used to study the unique structure and properties of biosynthesized nanoparticles. The results show the successful formation of metal-based particles in the range of nanometer, confirmed by different characterization techniques. Finally, the presented approach has been demonstrated to be effective in the biosynthesis of metal and metal oxide nanoparticles.


2017 ◽  
Vol 16 (2) ◽  
pp. 41-52
Author(s):  
N Shobhaa ◽  
N Nandab ◽  
B M Nagabhushana

Several methods are used to counter the deadly disease cancer. Zinc oxide nanoparticles (ZnO NPs) is one of the metal oxide nanoparticles which had been used in anti-cancer activities due to its large bandwidth and high exciting binding energy and it has potential applications like antibacterial, antifungal, anti-diabetic, anti-inflammatory, wound healing, antioxidant, optic properties and also which holds promise to treat cancer effectively. Studies have shown that Zinc metal oxide nano particles induce cytotoxicity in cancer cells. The mechanism for antitumor could work through apoptosis or the generation of reactive oxygen species or and necrosis, among other possibilities. This review is on some of the most significant antitumor results obtained with zinc oxide nanoparticles depending on their size, surface morphology, methods of preparation and also cytotoxicity result.


Molecules ◽  
2021 ◽  
Vol 26 (3) ◽  
pp. 584
Author(s):  
Omnia M. Elshayb ◽  
Khaled Y. Farroh ◽  
Heba E. Amin ◽  
Ayman M. Atta

Applications of metal oxide nanoparticles in the agriculture sector are being extensively included as the materials are considered superior. In the present work, zinc oxide nanoparticle (ZnO NPs), with a developing fertilizer, is applied in the fortification of rice grain yield and nutrient uptake enhancement. To evaluate the role of ZnO NP, two field experiments were conducted during the 2018 and 2019 seasons. ZnO NPs were small, nearly spherical, and their sizes equal to 31.4 nm, as proved via the dynamic light scattering technique. ZnO NPs were applied as a fertilizer in different concentrations, varying between 20 and 60 mg/L as a foliar spray. The mixture of ZnSO4 and ZnO NP40 ameliorated yield component and nutrients (N, K, and Zn) uptake was enhanced compared to traditional ZnSO4 treatment. Nevertheless, the uptake of the phosphorous element (P) was adversely affected by the treatment of ZnO NPs. Thus, treatment via utilizing ZnO NPs as a foliar with a very small amount (40 ppm) with of basal ZnSO4 led to a good improvement in agronomic and physiological features; eventually, higher yield and nutrient-enriched rice grain were obtained.


2013 ◽  
Vol 678 ◽  
pp. 203-206
Author(s):  
A. Alex John Thangapaul ◽  
V. Sherly Arpuda Kiruba ◽  
R. Nivea ◽  
T. Viji ◽  
K. Thiyagarajan ◽  
...  

Nanomaterials research has become a major attraction in the field of advanced materials research in the area of Physics, Chemistry, and Materials Science. Biocompatible and chemically stable magnetic metal oxide nanoparticles have biomedical applications that includes drug delivery, cell and DNA separation, gene cloning, magnetic resonance imaging (MRI). This research is aimed at the fabrication of magnetic cobalt oxide nanoparticles using a safe, cost effective, and easy to handle technique that is capable of producing nanoparticles free of any contamination. Nanostructured Cobalt oxide powder was prepared by sonication method using ultrasonicator. Effect of sonication for different time intervals, on the morphology of cobalt oxide nanostructures was extensively studied. The morphology of the nanorods were very much affected by the sonication time, it was found that with an increase in sonication time, the length of the nanorods seem to considerably increase at the same time an agglomeration effect comes in to action and the rods form bundle like structures. These cobalt oxide nanorods were characterized using X-ray Diffraction characterization (XRD) and it revealed a cubic structure. Weight percentage of cobalt oxide was confirmed by thermo gravimetric analysis (TGA).


2021 ◽  
Vol 12 (5) ◽  
pp. 6557-6579

The introduction of inorganic and organic pollutants into water bodies has become a serious issue globally. The waste streams released from the textile, plastic, leather, paper, pharmaceutical, and food industries introduce different natural and synthetic dyes into the aquatic system. Nanomaterials play a significant role in the photocatalytic degradation of dyes present in wastewater. Inorganic metal oxide nanoparticles have many improved physical and chemical properties and attracted much attention in photocatalytic activities. Dyes have been released in our aquatic bodies due to many anthropogenic activities and caused life-threatening problems. Various conventional methods were reported to remove dyes from water and wastewater; the photocatalytic method is one of the efficient and cost-effective. The present review article includes detailed information on photocatalysis, the potential of metal oxide and their composite materials as photocatalysts in the degradation of toxic dyes, and some common synthetic and characterization methods used for metal oxide-based nanoparticles.


2020 ◽  
Vol 3 (1) ◽  
pp. 15-27
Author(s):  
Priyankari Bhattacharya ◽  
Kasturi Chatterjee ◽  
Snehasikta Swarnakar ◽  
Sathi Banerjee

Application of metal oxide nanoparticles for treatment of melanoma cells and microbes is being investigated. Zinc oxide nanoparticles (ZnO NPs) deserve special mention where particles cause destruction of melanoma cells with minimal damage to healthy cells. In the present study, pure phase ZnO NPs with particle size of 3.1 nm were synthesized by green route using algal extract. Skin melanoma (B16F10) cells were treated with synthesized ZnO NP and compared with commercial ZnO NPs and analysed for ED50 for cellular viability using 3% (w/v) of the doses. Sensitivity of B16F10 cells towards green synthesized ZnO NP was found to be more than commercial ZnO NPs. Results showed greater reduction in viability of cells exposed to green synthesized ZnO NPs and with increasing dose of the ZnO NPs, percentage viability of cells gradually reduced. 50% decrease in cellular viability (ED50) was obtained for green synthesized ZnO NP at 3% dose while commercial ZnO exhibited ED50 at 6% of doses. The ZnO NP also showed antimicrobial activity against Pseudomonas sp. and Staphylococcus sp. Zone of inhibition (ZOI) exhibited by Pseudomonas aeruginosa and Staphylococcus aureus for disc diffusion and well diffusion assay was around 10-22 mm and 9-12mm respectively.


2021 ◽  
Author(s):  
Balaji GL ◽  
S. Mahesh ◽  
Boya Palajonnala Narasaiah ◽  
Sadegh Rostamnia ◽  
Harihara Padhy ◽  
...  

Abstract The present report an environmental benign route for the fabrication of Zinc Oxide nanoparticles (ZnO-NPs) using sunflower leaf aqueous extract at room temperature. This was an green method is a rapid biogenic and offers few advantages over the chemical and physical procedures, as it is an easy and fast, eco-friendly and does not involve any costly chemicals as well as hazardous chemicals, harmful solvent. The synthesized ZnO-NPs were characterized using different technique such as UV-Visible spectroscopy. The formation of ZnO-NPs was confirmed by Surface Plasmon Resonance (SRP) at 344 nm using UV-Vis spectroscopy. The leaf extract act as a source of phyto-chemicals and are the primarily responsible for the reduction and then formation of stable Zinc Oxide nanoparticles by the characteristic functional groups of extract and synthesized ZnO-NPs were identified by FTIR spectroscopy. Crystalline nature of ZnO-NPs was confirmed by powder –XRD. Size and morphology were measured by HR-TEM analysis. Stability of the nanoparticles is represented by DLS and TGA analysis. The synthesized ZnO-NPs has been found good and efficient catalyst for the synthesis of novel 1,2-dihydroquinazoline derivatives under green method via one pot reaction of 2-amino benzophenone, 1,3-diphenyl-1 H -pyrazole carbaldehydes and ammonium acetate. The synthesized compounds (4a-o) were characterized by 1 HNMR, 13 CNMR and HRMS spectra and further screened for radical scavenging activity. Among all the compounds showed good percentage of inhibition against standard ascorbic acid. The synthesized ZnO nanoparticles showed good antioxidant activity and also act as a good promising material for catalytic agent.


2021 ◽  
Vol 3 (1) ◽  
pp. 1-25
Author(s):  
Hemra Hamrayev ◽  
Kamyar Shameli ◽  
Mostafa Yusefi ◽  
Serdar Korpayev

Zinc oxide is of significant importance for many industries due to its versatile properties, which have been enhanced with the production of this material in the nanoscale. Recent interest in the preparation of metal oxide nanoparticles using biological approaches has been reported in the literature. This technique known as “green synthesis” is an environmentally benign process than conventional methods like physical and chemical synthesis methods. Zinc oxide nanoparticles (ZnO-NPs) have been successfully obtained by green synthesis using different biological substrates like chitosan. Chitosan is biocompatible, biodegradable polymer having exclusive physical and chemical properties. Chitosan/metal oxide nanocomposite is a promising nanomaterial with enhanced properties for multiple functionalities. Therefore, this review discusses favorable approach in the formation of cross-linked Chitosan/ZnO nanocomposites attracting significant attention in various fields such biomedical due to their unique biodegradable, biocompatible, non-toxic nature. The use of biological sources, fabrication of green synthesized ZnO nanoparticles and its applications is briefly discussed. Overall, this review is a comprehensive study for the synthesis of ZnO-NPs using biological sources counting on their features and applications.


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