scholarly journals Chemical composition of volatile components, antimicrobial and anticancer activity of n-hexane extract and essential oil from Trachyspermum ammi L. seeds

2014 ◽  
Vol 30 (4) ◽  
pp. 1653-1662 ◽  
Author(s):  
El-Sayed S Abdel-Hameed ◽  
Salih A Bazaid ◽  
Othman Al Zahrani ◽  
Yasser El-Halmouch ◽  
Mortada M El-Sayed ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Anticancer Activity ◽  
Hexane Extract ◽  
Volatile Components ◽  
Trachyspermum Ammi

scholarly journals Essential Oil from Arnica Montana L. Achenes: Chemical Characteristics and Anticancer Activity

Molecules ◽  
2019 ◽  
Vol 24 (22) ◽  
pp. 4158 ◽  
Author(s):  
Sugier ◽  
Sugier ◽  
Jakubowicz-Gil ◽  
Winiarczyk ◽  
Kowalski
Keyword(s):  
Chemical Composition ◽  
Glioblastoma Multiforme ◽  
Essential Oil ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Anaplastic Astrocytoma ◽  
Volatile Components ◽  
T98g Cell ◽  
Arnica Montana ◽  
Induction Of Apoptosis

Mountain arnica Arnica montana L. is a source of several metabolite classes with diverse biological activities. The chemical composition of essential oil and its major volatile components in arnica may vary depending on the geographical region, environmental factors, and plant organ. The objective of this study was to characterize the chemical composition of essential oil derived from A. montana achenes and to investigate its effect on induction of apoptosis and autophagy in human anaplastic astrocytoma MOGGCCM and glioblastoma multiforme T98G cell lines. The chemical composition of essential oil extracted from the achenes was examined with the use of Gas Chromatography–Mass Spectrometry GC-MS. Only 16 components of the essential oil obtained from the achenes of 3-year-old plants and 18 components in the essential oil obtained from the achenes of 4-year-old plants constituted ca. 94.14% and 96.38% of the total EO content, respectively. The main components in the EO from the arnica achenes were 2,5-dimethoxy-p-cymene (39.54 and 44.65%), cumene (13.24 and 10.71%), thymol methyl ether (8.66 and 8.63%), 2,6-diisopropylanisole (8.55 and 8.41%), decanal (7.31 and 6.28%), and 1,2,2,3-tetramethylcyclopent-3-enol (4.33 and 2.94%) in the 3- and 4-year-old plants, respectively. The essential oils were found to exert an anticancer effect by induction of cell death in anaplastic astrocytoma and glioblastoma multiforme cells. The induction of apoptosis at a level of 25.7–32.7% facilitates the use of this secondary metabolite in further studies focused on the development of glioma therapy in the future. Probably, this component plays a key role in the anticancer activity against the MOGGCCM and T98G cell lines. The present study is the first report on the composition and anticancer activities of essential oil from A. montana achenes, and further studies are required to explore its potential for future medicinal purposes.

scholarly journals Chemical Composition, Enantiomeric Distribution, and Biological Activities of Rhododendron anthopogon Leaf Essential Oil from Nepal

2016 ◽  
Vol 11 (12) ◽  
pp. 1934578X1601101 ◽  
Author(s):  
Noura S. Dosoky ◽  
Prabodh Satyal ◽  
Suraj Pokharel ◽  
William N. Setzer
Keyword(s):  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Biological Activities ◽  
Gas Chromatography Mass Spectrometry ◽  
Volatile Components ◽  
Cytotoxic Activities ◽  
Blood Disorders ◽  
Leaf Essential Oil ◽  
Microbroth Dilution

Rhododendron anthopogon D. Don., a small compact Himalayan shrub growing in Nepal, is a known medicinal plant used to treat sore throat, colds, blood disorders, bone disease, potato allergies, and vomiting, and to relieve liver disorders, headaches and back pain. The present study investigated the chemical composition and bioactivities of the leaf essential oil from R. anthopogon from Dhankuta, Nepal. The essential oil from leaves was obtained by hydrodistillation and a detailed chemical analysis was conducted by gas chromatography – mass spectrometry (GC-MS). The enantiomeric distribution of monoterpenoid components was determined using chiral gas chromatography and represents the first chiral examination of R. anthopogon essential oil. The essential oil was screened for antimicrobial activity using the microbroth dilution test, and for cytotoxic activity against MCF-7, MDA-MB-231, and 5637 using the MTT assay. A total of 70 volatile components were identified from the essential oil. The major components were α-pinene (21.5%), δ-cadinene (13.8%), β-pinene (9.5%), limonene (5.9%), δ-amorphene (4.6%), α-muurolene (4.5%), and ( E)-caryophyllene (3.2%) with other minor constituents (< 3%). The essential oil showed marginal antibacterial and cytotoxic activities, but no antifungal effects.

scholarly journals Chemical Composition of the Essential Oil of Gynoxys meridana from Mérida, Venezuela

2015 ◽  
Vol 10 (4) ◽  
pp. 1934578X1501000
Author(s):  
Johanna Hernández ◽  
Luis B. Rojas-Fermin ◽  
Juan Amaro-Luis ◽  
Laurent Pouységu ◽  
Stéphane Quideau ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Volatile Components

The volatile components from the fresh leaves of Gynoxys meridana Cuatrec. were obtained by hydrodistillation and analyzed by GC/MS. A total of 25 compounds, representing 99.3% of the oil, were identified. The dominant compounds were γ-curcumene (31.9%), fukinanolide (22.3%), β-pinene (9.5%), α-phellandrene (7.1%) and α-pinene (5.7%).

Chemical Composition of Essential Oil, Antioxidant, Antidiabetic, Anti-obesity, and Neuroprotective Properties of Prangos gaubae

2017 ◽  
Vol 12 (12) ◽  
pp. 1934578X1701201 ◽  
Author(s):  
Mir Babak Bahadori ◽  
Gokhan Zengin ◽  
Shahram Bahadori ◽  
Filippo Maggi ◽  
Leila Dinparast
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Skin Diseases ◽  
Biological Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Volatile Components ◽  
Total Antioxidant ◽  
Pharmaceutical Industries

Chemical composition of essential oil and the potential of Prangos gaubae for the management of public health problems such as Alzheimer's disease, obesity, Diabetes mellitus, and skin diseases were evaluated for the first time. In this direction, enzyme inhibitory effects, antioxidant activity, and total bioactive contents of the plant were determined. EO showed high acetylcholinesterase (2.97 mg GEs/g oil), α-amylase (1.35 mmol ACEs/g oil), α-glucosidase (38.84 mmol ACEs/g oil), and lipase (1.59 mmol OEs/g oil) inhibitory activities. Moreover, strong antioxidant effects were observed in antiradical (DPPH and ABTS), reducing power (CUPRAC and FRAP), total antioxidant, and metal chelating assays. Methanol extract exhibited promising DPPH radical scavenging activity (0.47 mmol TEs/g extract) and also high reducing power in CUPRAC (0.89 mmol TEs/g extract) and FRAP (0.52 mmol TEs/g extract) assays. All extracts showed low total flavonoid but high total phenolics content. Furthermore, they exhibited strong skin-care effect in tyrosinase inhibition assay. EO analysis showed the presence of germacrene D (26.7%), caryophyllene oxide (14.3%), ( E)-caryophyllene (13.8%), and spathulenol (11.3%) as the major volatile components. Results indicated that P. gaubae has promising potential for possible uses in food, cosmetic, and pharmaceutical industries due to its valuable phytoconstituents and biological activities.

Chemical composition and anticancer activity of leaf essential oil of Myrica gale L.

Phytomedicine ◽  
2005 ◽  
Vol 12 (4) ◽  
pp. 299-304 ◽  
Author(s):  
M. Sylvestre ◽  
J. Legault ◽  
D. Dufour ◽  
A. Pichette
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Anticancer Activity ◽  
Myrica Gale ◽  
Leaf Essential Oil

Chemical composition, oxidative stability and antiproliferative activity of Anethum graveolens (dill) seed hexane extract

2020 ◽  
Vol 71 (3) ◽  
pp. 374
Author(s):  
I. A. Nehdia ◽  
N. Abutaha ◽  
H. M. Sbihi ◽  
C. P. Tan ◽  
S. I. Al-Resayes
Keyword(s):  
Chemical Composition ◽  
Oxidative Stability ◽  
Antiproliferative Activity ◽  
Lipid Fraction ◽  
Hexane Extract ◽  
Gas Chromatography Mass Spectrometry ◽  
Breast Cancer Cell Lines ◽  
Volatile Fraction ◽  
Volatile Components ◽  
Anethum Graveolens

This study aimed to evaluate the physicochemical properties, chemical composition, and anti­proliferative activity of the hexane extract of Anethum graveolens L. (dill) seeds using gas chromatography mass spectrometry (GC-MS). Two fractions, namely the lipid fraction (74%) and volatile fraction (26%), were detected. The extract content of the seeds was about 9.4% and the extract had a pleasant spicy aroma. Oleic acid (52%), cis-vaccenic acid (6.2%), linoleic acid (5.5%), and palmitic acid (3.3%) were the key fatty acids in the lipid fraction, while apiol (23%) and d-carvone (2.4%) were the major volatile components. Tocols (tocopherols and tocotrienols) were also detected in the A. Graveolens extract (155 mg/100 g) and b-tocopherol was identified as the major tocol (71%). Dill extract showed a high oxidative stability (induction time = 45.22 h). Furthermore, dill extract showed antiproliferative activity against breast cancer cell lines.

scholarly journals Volatile Leaf Constituents and Anticancer Activity of Bursera Simaruba (L.) Sarg. Essential Oil

2007 ◽  
Vol 2 (12) ◽  
pp. 1934578X0700201 ◽  
Author(s):  
Muriel Sylvestre ◽  
André Pichette Angélique Longtin ◽  
Jean Legault
Keyword(s):  
Essential Oil ◽  
Anticancer Activity ◽  
Cell Line ◽  
Colon Adenocarcinoma ◽  
Human Colon ◽  
Volatile Components ◽  
Bursera Simaruba ◽  
Tropical America ◽  
Human Lung Carcinoma ◽  
Human Lung Carcinoma Cell

Leaf volatile components of Bursera simaruba (L.) Sarg., a native tree from tropical America used in traditional medicine, were extracted by hydrodistillation. The essential oil was analyzed by GC-MS. We have identified 38 compounds in this oil, of which limonene (46.7%), β-caryophyllene (14.7%), α-humulene (13.2%) and germacrene D (7.6%) are the major components. The anticancer activity of the essential oil was tested on human lung carcinoma cell line A-549 and human colon adenocarcinoma cell line, DLD-1. B. simaruba leaf essential oil was found to be active against both tumor cell lines, with a GI50 of 42 ± 2 μg/mL for A-549 and 48 ± 2 μg/mL for DLD-1. The evaluation of the cytotoxic properties of the major constituents of the oil indicates that α-humulene is possibly responsible for this activity.

scholarly journals Evaluation of Chemical Composition of Hamadan Propolis as a Potential Anticancer Agent

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Dara Datan ◽  
Roghayeh Mahmoudi ◽  
Massoud Saidijam ◽  
Saeideh Gholamzadeh Khoei ◽  
Maede Hasan Abdali ◽  
...  
Keyword(s):  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Anticancer Activity ◽  
Cell Line ◽  
Phenolic Content ◽  
Methanolic Extract ◽  
Hct116 Cell ◽  
Total Flavonoid ◽  
Hct116 Cell Line

: This study aimed to evaluate the chemical composition and anticancer activity of Hamadan propolis essential oil and methanolic extract on HCT116 cell line. The anticancer activity of propolis methanolic extract and essential oil was evaluated by using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) test on the colorectal HCT116 cell line. The essential oil of Hamadan propolis was analyzed by gas chromatography-flame ionization detection (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The total flavonoid and phenolic content of methanolic extract were assessed using the aluminum chloride colorimetric procedures and Folin-Ciocalteu (F-C) assay, respectively. The results of MTT assay confirmed the anticancer properties of Hamadan propolis essential oil and methanolic extract on the HCT116 cell line. Moreover, 30 compounds were characterized from Hamadan propolis essential oil, the main compounds of which included β-udesmol (25.7%), α-udesmol (20.4%), α-copaen-11-ol (13.7%), and γ-udesmol (10.1%). In addition, the total flavonoid content and total phenolic content of the methanolic extract were 14.12 mg/g and 32.01 mg/g dry weight, respectively. In summary, the most important constituents of Hamadan propolis essential oil were β-u desmol, α-eudesmol, α-copaen, and γ-u desmol. Despite the cytotoxic effects of Hamadan propolis methanolic extract and essential oil on HCT116, further evaluation of anticancer effects of the most important constituents of propolis methanolic extract and essential oil is recommended.

scholarly journals Essential Oil Chemical Composition of Mentha mozaffarianii Jamzad Seeds

2017 ◽  
Vol 60 (1) ◽  
Author(s):  
Sara Tavakkoli-Khaledi ◽  
Jinous Asgarpanah
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Chemical Composition ◽  
Essential Oil ◽  
Endemic Species ◽  
Volatile Components ◽  
The South ◽  
Main Components

The seeds essential oil of the endemic species <em>Mentha mozaffarianii</em> growing wild in the south of Iran was analyzed by gas chromatography (GC) and GC-mass spectrometry (GC-MS). Charac-terization of individual components was performed using a commer-cial mass spectrometry library, and 25 components were identified. This analysis showed the presence of 3 volatile components, including piperitenone (35.6%), piperitone (27.1%) and 1,8-cineol (10.7%) as the main components.

scholarly journals STUDY OF THE CHEMICAL COMPOSITION IN LEAVES AND OIL OF Cananga odorata (Lam.) IN BEN TRE PROVINCE

2020 ◽  
Vol 1 (40) ◽  
pp. 92-102
Author(s):  
Chau Nguyen Minh Doan ◽  
Tin Thanh Nguyen
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Hexane Extract ◽  
Geranyl Acetate ◽  
Crystalline Solid ◽  
Water Volume ◽  
Fresh Weight ◽  
Benzyl Benzoate ◽  
Physical And Chemical ◽  
Cananga Odorata

Investigation of the chemical composition of Cananga odorata(Lam.) leaves and essential oil in Ben Tre Province was conducted with steamenticing distillation method, extraction nhexane and Soxhlet with the solvents of nhexane, dietyl ether respectively. The results have determined the distillation conditions and the content of Cananga odorata (Lam.) essential oil by fresh weight and water volume is: 1: 3 (gram / ml)with distillation time: 3 to 4 hours. The content essential oil of Cananga odorata (Lam.) flower obtained in dry weight is 1.10% -1.26% and in fresh weight is 0.56% - 0.65%. The results of the study identified some physical and chemical indexes: the essential oil of Cananga odorata (Lam.) flower in Ben Tre is yellow, clear, has a stronger aroma and is lighter than water; Physical and chemical indices of the essential oil of Cananga odorata(Lam.) flower measured in three different lands of Ben Tre and collected during the same period showed: The density changed from 0.92 - 0.95; Refractive index varies from 1.4952 - 1.4991; The acid index varies from 0.13 to 0.38; The ester index ranged from 37.55 to 38.11; The saponification index ranged from 37.67 to 38.49. Mass SpectrometryMS method has been identified that the main chemical composition the essential oil of Cananga odorata (Lam.) flower in three regions are consistent with the results of the authors who have studied theessential oil of Cananga odorata (Lam.) flower in the North and include the following components: L-linalol, geraniol, geranyl axetat, benzyl benzoat, anđehit benzoic, etyl benzoat, D-germacren,... In which, the main ingredents of Cananga odorata (Lam.) flower in n-hexane extract are: benzyl benzoate, D-germacren,L-linalol, b-caryophyllen; The main components when make in dietyl ether are: benzyl benzoate, geranyl acetate, anisyl acetone, D-germacren; The main ingredients of Cananga odorata (Lam.) leaf inn-hexane extract include: L-linalol, transgeraniol, geranyl acetate,...From n-hexane solvent extract, we isolated, purified and determined the structure of the crystalline solid is benzyl benzoate.

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