scholarly journals Study of Multifaceted Effect of Vitexnegundo Leaves Aqueous Extract and Decoction for Pain Relief in Experimental Models

2021 ◽  
Vol 14 (3) ◽  
pp. 1661-1667
Author(s):  
Khatavkar P. S ◽  
Dawane J. S ◽  
Avinash Sarak
Keyword(s):  
Skeletal Muscle ◽  
Pain Relief ◽  
Aqueous Extract ◽  
Muscle Relaxant ◽  
Muscle Relaxation ◽  
Anxiolytic Effect ◽  
Warning Signal ◽  
Experimental Models ◽  
Standard Drug ◽  
Skeletal Muscle Relaxant

Background: Pain is the warning signal of underlying pathology. Analgesic drugs are used as per the severity of pain. These drugs have their own adverse drug reactions, sometimes requiring the discontinuation of treatment. Perception and reaction to the pain are two important facets of pain. Reaction in the form of fear,restlessness, spasm of the muscles etc. are seen. Effectiveness of Vitexnegundoin pain have been studied, we planned to evaluate the associated components of it. Objectives: To evaluate, the Analgesic action, Anxiolytic action and Muscle relaxant action of Vitexnegundo leaves aqueous extract (VNLE) and Vitexnegundo dried leaves decoction (VNDLD). Material and methods: Fresh prepared VNLE and VNDLD are the two preparations of Vitexnegundo used to evaluate the analgesic, anxiolytic and skeletal muscle relaxant activity. Wistar rats and mice of either sex were divided into four groups, control, positive control, VNLE&VNDLD. Standard drug pentazocine& diazepam were used for analgesic & skeletal muscle relaxant property respectively. Rats were exposed to hot plate for Analgesic activity, elevated plus maze (EPM) for anxiolytic effect and mice to rotarod apparatus for checking skeletal muscle relaxation after the drug treatment.Analysis was done with graph pad prism 6. Results: Pain threshold was significantly increased at (p<0.001) Pentazocine and (p<0.01) in Vitexnigundo juice as observed from increase in reaction time. VNLE and VNDLD significantly showed positive effect on the parameters of the EPM. This observation was comparable with the standard drug diazepam. Time spent on the rota rod was significantly reduced in all drug treated mice. Conclusion:Analgesic and antianxiety activity of Vitexnegundo is confirmed.Fresh juice VNLE was more effective than the VNDLD. It also possesses skeletal muscle relaxant action, enhancing the pain relief.

scholarly journals Evaluation of centrally acting skeletal muscle relaxant activity of aqueous extract of Withania somnifera (ashwagandha) roots in albino mice

2018 ◽  
Vol 8 (1) ◽  
pp. 157
Author(s):  
Sarita Panigrahy
Keyword(s):  
Skeletal Muscle ◽  
Aqueous Extract ◽  
Muscle Relaxant ◽  
Withania Somnifera ◽  
Standard Drug ◽  
Skeletal Muscle Relaxant ◽  
Albino Mice ◽  
The Difference ◽  
Muscle Relaxant Activity ◽  
Off Time

Background: Skeletal muscle relaxants are used to treat both muscle spasm and spasticity, acting both as antispasmodic and antispasticity agents. In past studies some polyherbal formulations containing ashwagandha have shown skeletal muscle relaxant activity and fat extract of ashwagandha showed skeletal muscle relaxant activity in experimental animal models. This study is designed to evaluate the skeletal muscle relaxant activity of aqueous extract of Withania somnifera (ashwagandha) roots in albino mice, as the literature regarding them is limited.Methods: Standard drug (diazepam) and different doses of Aqueous extract of ashwagandha (50, 100,150mg/kg) were given orally to albino mice. Skeletal muscle relaxant activity was assessed by Rota-rod apparatus. The fall off time from the rotating rod was noted for each group after 1 hour of drug administration. The difference in fall off time from the rotating rod between the standard and treated mice was taken as an index of muscle relaxation.Results: The test extract at doses (50mg/kg, 100mg/kg and 150mg/kg) showed highly significant reduction in the time spent by the animals on revolving rod in rota rod test when compared to baseline (p <0.0001). As compared with diazepam, aqueous extract (150mg/kg) showed almost equal reduction in the time spent by the animals on revolving rod in rota rod test.Conclusions: This study indicates that the aqueous extract of ashwagandha possess central skeletal muscle relaxant activity. The results are promising for further investigation of efficient skeletal muscle relaxant activity.

Evaluation of Skeletal Muscle Relaxant Activity of Apigenin in Animal Experimental Models

2021 ◽  
Vol 17 (6) ◽  
pp. 400-407
Author(s):  
Syed Mohammed Basheerudd ◽  
Basheerahmed Abdulaziz ◽  
Ahmad Alanazi ◽  
Bader Almusharra ◽  
Naif Alanazi ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Experimental Models ◽  
Skeletal Muscle Relaxant ◽  
Muscle Relaxant Activity

EVALUATION OF CENTRALLY ACTING SKELETAL MUSCLE RELAXANT ACTIVITY OF ALCOHOLIC EXTRACTS OF ASHWAGANDHA (WITHANIA SOMNIFERA) ROOTS IN ALBINO MICE.

2021 ◽  
pp. 62-64
Author(s):  
Sarita Panigrahy ◽  
Sangeeta Panigrahy
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Withania Somnifera ◽  
Standard Drug ◽  
Alcohol Extract ◽  
Skeletal Muscle Relaxant ◽  
Albino Mice ◽  
Muscle Relaxant Activity ◽  
Off Time ◽  
Different Doses

BACKGROUND:Skeletal muscle relaxants are drugs that are used to relax and diminish tightness in muscles. Many medicinal plants have known to have skeletal muscle relaxant activity. In past studies some Polyherbal formulation containing Ashwagandha as one of the ingredients and its fat extract have shown to have skeletal muscle relaxant activity in experimental animal models. This study is intended to evaluate the skeletal muscle relaxant activity of alcoholic extracts of Withania Somnifera (Ashwagandha) roots in albino mice, as the literature regarding this extract is scarce. METHODOLOGY: Standard drug (diazepam), different doses of Alcohol extract of ashwagandha (50,100, 150 mg/kg) were given orally to mice and muscle relaxant activity was assessed by Rota-rod apparatus. The fall off time from the rotating rod was noted for each group after 1 hour of drug administration. The difference in fall off time among the standard drug and treated mice was taken as an index of muscle relaxation. RESULTS:The test extract at its different doses showed highly signicant reduction in the time spent by the animals on revolving rod in rotarod test when compared to baseline (p < 0.0001) which is highly signicant. On comparison with diazepam, different doses of Alcohol extract showed weak relaxant activity. CONCLUSIONS : The three different doses of Alcoholic extract showed a dose dependent rise in muscle relaxant action. The results are promising for further investigation of efcient skeletal muscle relaxant activity.

scholarly journals A study to evaluate the skeletal muscle relaxant property of Pregabalin and Gabapentin in albino rats

2019 ◽  
Vol 8 (6) ◽  
pp. 1381 ◽  
Author(s):  
Sushma V. Naidu ◽  
Vibha Rani
Keyword(s):  
Skeletal Muscle ◽  
Muscle Relaxant ◽  
Muscle Relaxation ◽  
Statistical Significance ◽  
Muscle Relaxants ◽  
Control Group ◽  
Albino Rats ◽  
Skeletal Muscle Relaxant ◽  
Significant Difference ◽  
Group 5

Background: Skeletal muscle relaxants are the drugs which reduce unwanted spasm without interfering with consciousness and voluntary movements. The centrally acting muscle relaxants like Diazepam, is known to be GABA mimetics and other antiepileptics like Gabapentin and Pregabalin also act through the release of GABA. This study is done to investigate skeletal muscle relaxant property of these drugs in comparison to Diazepam.Methods: T Models used in the experiment are Grip Strength Test, Rota Rod Method, Beam Walk Test, Photoactometer Test. Animals were divided into 6 groups of 6 rats each: Group 1: Control group treated with normal saline (0.1 ml/10gm), Group 2: Standard-15mg/kg of Diazepam, Group 3:T1-60 mg/kg of Gabapentin, Group 4:T2-10 mg/kg of Pregabalin, Group 5:T3-60 mg/kg of Gabapentin+Diazepam, Group 6:T4- 10 mg/kg of Pregabalin+Diazepam. Mean and standard deviation was calculated for each group. One way ANOVA was used for multiple group comparisons followed by post hoc Tukey’s test for statistical significance between the groups.Results: Treatment with the above test drugs produced significant muscle relaxation and caused decreased fall off, sliding time, increase climbing time and decreased locomotor activity in all models indicating motor incoordination. The results obtained from both standard and test groups showed a highly significant difference in muscle relaxation when compared with the control group.Conclusions: The test drugs showed skeletal muscle relaxant property in rats comparable to Diazepam. In view of these results, it can open a new avenue for these drugs to be used as skeletal muscle relaxants after conducting clinical trials.

scholarly journals Potential Benefits of Gallic Acid As Skeletal Muscle Relaxant In Animal Experimental Models

2021 ◽  
Author(s):  
Syed Mohammed Basheeruddin Asdaq ◽  
Abdulhakeem S. Alamri ◽  
Walaa F. Alsanie ◽  
Majid Alhomrani ◽  
Farhana Yasmin
Keyword(s):  
Skeletal Muscle ◽  
Gallic Acid ◽  
Muscle Relaxant ◽  
Experimental Models ◽  
Skeletal Muscle Relaxant ◽  
Potential Benefits

scholarly journals Antidepressant and skeletal muscle relaxant effects of the aqueous extract of the Prosopis cineraria

2012 ◽  
Vol 48 (3) ◽  
pp. 577-581 ◽  
Author(s):  
Mathew George ◽  
Lincy Joseph ◽  
Abishika Sharma
Keyword(s):  
Skeletal Muscle ◽  
Aqueous Extract ◽  
Muscle Relaxant ◽  
Forced Swim Test ◽  
Antidepressant Effect ◽  
Control Group ◽  
Skeletal Muscle Relaxant ◽  
Prosopis Cineraria ◽  
Immobility Time ◽  
And Control

The aqueous leaves extract of Prosopis cineraria (AEPC) is used traditionally for the treatment of various CNS disorder. The purpose of this study was to evaluate the extract for antidepressant and skeletal muscle relaxant activity. The antidepressant effect of the extract was evaluated using Forced swim test (FST). The immobility periods of control and treated mice were recorded. The antidepressant-like effect of tested compound was compared to that of imipramine (15 mg/kg. p.o). Muscle relaxant property was studied using rotarod apparatus and total fall off time for standard and control group was recorded. Phytochemical screening revealed the presence of saponins, flavonoids, alkaloids, glycosides, tannins and phenolic compounds. The leaf extract at doses of 200 mg/kg significantly decreased the duration of immobility time in FST. The efficacy of tested extract was found to be comparable to that of imipramine. Our results suggested that the aqueous extract of Prosopis cineraria leaves exerts antidepressant-like effect.

scholarly journals Evaluation of skeletal muscle relaxant activity of aqueous extract of Nerium oleander flowers in Albino rats

2015 ◽  
Vol 47 (4) ◽  
pp. 409
Author(s):  
Jayasree Tirumalasetti ◽  
Maulik Patel ◽  
Ubedulla Shaikh ◽  
K Harini ◽  
J Shankar
Keyword(s):  
Skeletal Muscle ◽  
Aqueous Extract ◽  
Muscle Relaxant ◽  
Nerium Oleander ◽  
Albino Rats ◽  
Skeletal Muscle Relaxant ◽  
Muscle Relaxant Activity
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