scholarly journals Genetic Algorithm Approach to Find the Estimated Value of HMM parametersfor NS5 Methyltransferase Protein

2021 ◽  
Vol 14 (3) ◽  
pp. 1567-1578
Author(s):  
Nidhi Katiyar ◽  
Ravindra Nath ◽  
Shashwat Katiyar
Keyword(s):  
Machine Learning ◽  
Genetic Algorithm ◽  
Search Algorithm ◽  
Specific Treatment ◽  
Machine Learning Techniques ◽  
Severe Dengue ◽  
Severe Illness ◽  
Support Vector ◽  
Learning Approaches ◽  
Observation Sequence

Dengue is the pandemic disease caused by Dengue virus (DENV), a mosquito-borne flavivirus. In recent years dengue has emerged as a foremost cause of severe illness and deaths in developing countries.About 400 million dengue infections occur worldwide each year.In general, dengue infections create only mild illness but infrequently expand into a lethal illness termed as severe dengue for which no specific treatment. The machine learning approach plays a significant role in bioinformatics and other fields of computer science.It exploitsapproaches like Hidden Markov Model (HMM), Genetic Algorithm (GA), Artificial Neural Network (ANN), and Support Vector Machine (SVM).The GA is a randomized search algorithm for solving the problem based on natural selection phenomena.Many machine learning techniques are based on HMM have been positively applied. In this work, We firstly used HMM parameters on the biological sequence,and after that, we catch the probability of the observation sequence of a mutated gene sequence. This study comparesboth methods, G.A. and HMM, to get the highest estimated value of the observation sequence. In this paper, we also discuss the applications ofGA in the bioinformatics field. In a further study, we will apply the other machine learning approaches to find the best result of protein studies.

scholarly journals Machine Learning Frameworks in Cancer Detection

2021 ◽  
Vol 297 ◽  
pp. 01073
Author(s):  
Sabyasachi Pramanik ◽  
K. Martin Sagayam ◽  
Om Prakash Jena
Keyword(s):  
Machine Learning ◽  
Prediction Models ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Cancer Development ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Techniques ◽  
Fact Finding ◽  
Risk Of Cancer

Cancer has been described as a diverse illness with several distinct subtypes that may occur simultaneously. As a result, early detection and forecast of cancer types have graced essentially in cancer fact-finding methods since they may help to improve the clinical treatment of cancer survivors. The significance of categorizing cancer suffers into higher or lower-threat categories has prompted numerous fact-finding associates from the bioscience and genomics field to investigate the utilization of machine learning (ML) algorithms in cancer diagnosis and treatment. Because of this, these methods have been used with the goal of simulating the development and treatment of malignant diseases in humans. Furthermore, the capacity of machine learning techniques to identify important characteristics from complicated datasets demonstrates the significance of these technologies. These technologies include Bayesian networks and artificial neural networks, along with a number of other approaches. Decision Trees and Support Vector Machines which have already been extensively used in cancer research for the creation of predictive models, also lead to accurate decision making. The application of machine learning techniques may undoubtedly enhance our knowledge of cancer development; nevertheless, a sufficient degree of validation is required before these approaches can be considered for use in daily clinical practice. An overview of current machine learning approaches utilized in the simulation of cancer development is presented in this paper. All of the supervised machine learning approaches described here, along with a variety of input characteristics and data samples, are used to build the prediction models. In light of the increasing trend towards the use of machine learning methods in biomedical research, we offer the most current papers that have used these approaches to predict risk of cancer or patient outcomes in order to better understand cancer.

scholarly journals A Machine Learning View on Momentum and Reversal Trading

Algorithms ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 170 ◽  
Author(s):  
Zhixi Li ◽  
Vincent Tam
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Stock Market ◽  
Short Term Memory ◽  
Predictive Ability ◽  
Trading Strategies ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Techniques

Momentum and reversal effects are important phenomena in stock markets. In academia, relevant studies have been conducted for years. Researchers have attempted to analyze these phenomena using statistical methods and to give some plausible explanations. However, those explanations are sometimes unconvincing. Furthermore, it is very difficult to transfer the findings of these studies to real-world investment trading strategies due to the lack of predictive ability. This paper represents the first attempt to adopt machine learning techniques for investigating the momentum and reversal effects occurring in any stock market. In the study, various machine learning techniques, including the Decision Tree (DT), Support Vector Machine (SVM), Multilayer Perceptron Neural Network (MLP), and Long Short-Term Memory Neural Network (LSTM) were explored and compared carefully. Several models built on these machine learning approaches were used to predict the momentum or reversal effect on the stock market of mainland China, thus allowing investors to build corresponding trading strategies. The experimental results demonstrated that these machine learning approaches, especially the SVM, are beneficial for capturing the relevant momentum and reversal effects, and possibly building profitable trading strategies. Moreover, we propose the corresponding trading strategies in terms of market states to acquire the best investment returns.

Brain Signal Classification Based on Deep CNN

2020 ◽  
Vol 12 (2) ◽  
pp. 17-29
Author(s):  
Terry Gao ◽  
Grace Ying Wang
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Mental Status ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Imaging Features ◽  
Learning Approaches ◽  
Computationally Efficient ◽  
Set Up ◽  
Brain Data

It is essential to increase the accuracy and robustness of classification of brain data, including EEG, in order to facilitate a direct communication between the human brain and computerized devices. Different machine learning approaches, such as support vector machine (SVM), neural network, and linear discrimination analysis (LDA), have been applied to set up automatic subjective-classifier, and the findings for their capacities in this regard have been inconclusive. The present study developed an effective classifier for human mental status using deep learning in a convolutional neural network. In contrast to most previous studies commonly using EEG waveform or numeric value of brain signals for classification, the authors utilised imaging features generated from EEG data at alpha frequency band. A new model proposed in this study provides a simple and computationally efficient approach to distinguish mental status during resting. With training, this model could predict new 2D EEG images with above 90% accuracy, while traditional machine learning techniques failed to achieve this accuracy.

scholarly journals Sentiment Analysis of Lithuanian Texts Using Traditional and Deep Learning Approaches

Computers ◽  
2019 ◽  
Vol 8 (1) ◽  
pp. 4 ◽  
Author(s):  
Jurgita Kapočiūtė-Dzikienė ◽  
Robertas Damaševičius ◽  
Marcin Woźniak
Keyword(s):  
Machine Learning ◽  
Deep Learning ◽  
Sentiment Analysis ◽  
Short Term Memory ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Full Dataset ◽  
Learning Techniques ◽  
Long Short Term Memory

We describe the sentiment analysis experiments that were performed on the Lithuanian Internet comment dataset using traditional machine learning (Naïve Bayes Multinomial—NBM and Support Vector Machine—SVM) and deep learning (Long Short-Term Memory—LSTM and Convolutional Neural Network—CNN) approaches. The traditional machine learning techniques were used with the features based on the lexical, morphological, and character information. The deep learning approaches were applied on the top of two types of word embeddings (Vord2Vec continuous bag-of-words with negative sampling and FastText). Both traditional and deep learning approaches had to solve the positive/negative/neutral sentiment classification task on the balanced and full dataset versions. The best deep learning results (reaching 0.706 of accuracy) were achieved on the full dataset with CNN applied on top of the FastText embeddings, replaced emoticons, and eliminated diacritics. The traditional machine learning approaches demonstrated the best performance (0.735 of accuracy) on the full dataset with the NBM method, replaced emoticons, restored diacritics, and lemma unigrams as features. Although traditional machine learning approaches were superior when compared to the deep learning methods; deep learning demonstrated good results when applied on the small datasets.

Classification of volcanic and tectonic earthquakes in Kamchatka (Russia) with different machine learning techniques

2020 ◽  
Author(s):  
Natalia Galina ◽  
Nikolai Shapiro ◽  
Leonard Seydoux ◽  
Dmitry Droznin
Keyword(s):  
Machine Learning ◽  
Subduction Zone ◽  
Aftershock Sequence ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Shiveluch Volcano ◽  
Agglomerative Clustering ◽  
Learning Techniques ◽  
Single Station

<p>Kamchatka is an active subduction zone that exhibits intense seismic and volcanic activities. As a consequence, tectonic and volcanic earthquakes are often nearly simultaneously recorded at the same station. In this work, we consider seismograms recorded between December 2018 and April 2019. During this time period when the M=7.3 earthquake followed by an aftershock sequence occurred nearly simultaneously with a strong eruption of Shiveluch volcano. As a result, stations of the Kamchatka seismic monitoring network recorded up to several hundreds of earthquakes per day. In total, we detected almost 7000 events of different origin using a simple automatic detection algorithm based on signal envelope amplitudes. Then, for each detection different features have been extracted. We started from simple signal parameters (amplitude, duration, peak frequency, etc.), unsmoothed and smoothed spectra and finally used a multi-dimensional signal decomposition (scattering coefficients). For events classification both unsupervised (K-means, agglomerative clustering) and supervised (Support Vector Classification, Random Forest) classic machine learning techniques were performed on all types of extracted features. Obtained results are quite stable and do not vary significantly depending on features and method choice. As a result, the machine learning approaches allow us to clearly separate tectonic subduction-zone earthquakes and those associated with the Shiveluch volcano eruptions based on data of a single station.</p>

scholarly journals A Robust Isolated Automatic Speech Recognition System using Machine Learning Techniques

2019 ◽  
Vol 8 (10) ◽  
pp. 2325-2331
Keyword(s):  
Machine Learning ◽  
Feature Extraction ◽  
Speech Recognition ◽  
Speaker Recognition ◽  
Search Algorithm ◽  
Recognition System ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Speech Recognition System ◽  
Work Done

In order to make fast communication between human and machine, speech recognition system are used. Number of speech recognition systems have been developed by various researchers. For example speech recognition, speaker verification and speaker recognition. The basic stages of speech recognition system are pre-processing, feature extraction and feature selection and classification. Numerous works have been done for improvement of all these stages to get accurate and better results. In this paper the main focus is given to addition of machine learning in speech recognition system. This paper covers architecture of ASR that helps in getting idea about basic stages of speech recognition system. Then focus is given to the use of machine learning in ASR. The work done by various researchers using Support vector machine and artificial neural network is also covered in a section of the paper. Along with this review is presented on work done using SVM, ELM, ANN, Naive Bayes and kNN classifier. The simulation results show that the best accuracy is achieved using ELM classifier. The last section of paper covers the results obtained by using proposed approaches in which SVM, ANN with Cuckoo search algorithm and ANN with back propagation classifier is used. The focus is also on the improvement of pre-processing and feature extraction processes.

Evaluation of Machine Learning Approaches for Automated Diagnosis of COVID-19 using X-Ray images (Preprint)

2020 ◽  
Author(s):  
Mazin Mohammed ◽  
Karrar Hameed Abdulkareem ◽  
Mashael S. Maashi ◽  
Salama A. Mostafa A. Mostafa ◽  
Abdullah Baz ◽  
...  
Keyword(s):  
Machine Learning ◽  
Computational Method ◽  
Learning Performance ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Data Set ◽  
X Ray ◽  
Wide Range ◽  
Artificial Neural Network Ann

BACKGROUND In most recent times, global concern has been caused by a coronavirus (COVID19), which is considered a global health threat due to its rapid spread across the globe. Machine learning (ML) is a computational method that can be used to automatically learn from experience and improve the accuracy of predictions. OBJECTIVE In this study, the use of machine learning has been applied to Coronavirus dataset of 50 X-ray images to enable the development of directions and detection modalities with risk causes.The dataset contains a wide range of samples of COVID-19 cases alongside SARS, MERS, and ARDS. The experiment was carried out using a total of 50 X-ray images, out of which 25 images were that of positive COVIDE-19 cases, while the other 25 were normal cases. METHODS An orange tool has been used for data manipulation. To be able to classify patients as carriers of Coronavirus and non-Coronavirus carriers, this tool has been employed in developing and analysing seven types of predictive models. Models such as , artificial neural network (ANN), support vector machine (SVM), linear kernel and radial basis function (RBF), k-nearest neighbour (k-NN), Decision Tree (DT), and CN2 rule inducer were used in this study.Furthermore, the standard InceptionV3 model has been used for feature extraction target. RESULTS The various machine learning techniques that have been trained on coronavirus disease 2019 (COVID-19) dataset with improved ML techniques parameters. The data set was divided into two parts, which are training and testing. The model was trained using 70% of the dataset, while the remaining 30% was used to test the model. The results show that the improved SVM achieved a F1 of 97% and an accuracy of 98%. CONCLUSIONS :. In this study, seven models have been developed to aid the detection of coronavirus. In such cases, the learning performance can be improved through knowledge transfer, whereby time-consuming data labelling efforts are not required.the evaluations of all the models are done in terms of different parameters. it can be concluded that all the models performed well, but the SVM demonstrated the best result for accuracy metric. Future work will compare classical approaches with deep learning ones and try to obtain better results. CLINICALTRIAL None

Investigating Machine Learning Techniques for User Sentiment Analysis

2019 ◽  
Vol 11 (3) ◽  
pp. 1-12 ◽  
Author(s):  
Nimesh V Patel ◽  
Hitesh Chhinkaniwala
Keyword(s):  
Machine Learning ◽  
Sentiment Analysis ◽  
Social Networking Sites ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Product Reviews ◽  
Learning Approaches ◽  
Current Trends ◽  
Learning Techniques ◽  
Benchmark Datasets

Sentiment analysis identifies users in the textual reviews available in social networking sites, tweets, blog posts, forums, status updates to share their emotions or reviews and these reviews are to be used by market researchers to do know the product reviews and current trends in the market. The sentiment analysis is performed by two methods. Machine learning approaches and lexicon methods which are also known as the knowledge base approach. These. In this article, the authors evaluate the performance of some machine learning techniques: Maximum Entropy, Naïve Bayes and Support Vector Machines on two benchmark datasets: the positive-negative dataset and a Movie Review dataset by measuring parameters like accuracy, precision, recall and F-score. In this article, the authors present the performance of various sentiment analysis and classification methods by classifying the reviews in binary classes as positive, negative opinion about reviews on different domains of dataset. It is also justified that sentiment analysis using the Support Vector Machine outperforms other machine learning techniques.

scholarly journals Evaluation Of Machine Learning Tools For Distinguishing Fraud From Error

2013 ◽  
Vol 11 (9) ◽  
pp. 393
Author(s):  
Mei Zhang
Keyword(s):  
Machine Learning ◽  
Binary Classification ◽  
Classification Problem ◽  
General Purpose ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Tools ◽  
Pure Chance ◽  
Error Classification

<p>Fraud and error are two underlying sources of misstated financial statements. Modern machine learning techniques provide a potential direction to distinguish the two factors in such statements. In this paper, a thorough evaluation is conducted evaluation on how the off-the-shelf machine learning tools perform for fraud/error classification. In particular, the task is treated as a standard binary classification problem; i.e., mapping from an input vector of financial indices to a class label which is either error or fraud. With a real dataset of financial restatements, this study empirically evaluates and analyzes five state-of-the-art classifiers, including logistic regression, artificial neural network, support vector machines, decision trees, and bagging. There are several important observations from the experimental results. First, it is observed that bagging performs the best among these commonly used general purpose machine learning tools. Second, the results show that the underlying relationship from the statement indices to the fraud/error decision is likely to be non-linear. Third, it is very challenging to distinguish error from fraud, and general machine learning approaches, though perform better than pure chance, leave much room for improvement. The results suggest that more advanced or task-specific solutions are needed for fraud/error classification.</p>

Prediction of drug synergy in cancer using ensemble-based machine learning techniques

2018 ◽  
Vol 32 (11) ◽  
pp. 1850132 ◽  
Author(s):  
Harpreet Singh ◽  
Prashant Singh Rana ◽  
Urvinder Singh
Keyword(s):  
Machine Learning ◽  
Fuzzy Inference System ◽  
Fuzzy Inference ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Prediction Errors ◽  
Learning Approaches ◽  
Inference System ◽  
Drug Synergy ◽  
Learning Techniques

Drug synergy prediction plays a significant role in the medical field for inhibiting specific cancer agents. It can be developed as a pre-processing tool for therapeutic successes. Examination of different drug–drug interaction can be done by drug synergy score. It needs efficient regression-based machine learning approaches to minimize the prediction errors. Numerous machine learning techniques such as neural networks, support vector machines, random forests, LASSO, Elastic Nets, etc., have been used in the past to realize requirement as mentioned above. However, these techniques individually do not provide significant accuracy in drug synergy score. Therefore, the primary objective of this paper is to design a neuro-fuzzy-based ensembling approach. To achieve this, nine well-known machine learning techniques have been implemented by considering the drug synergy data. Based on the accuracy of each model, four techniques with high accuracy are selected to develop ensemble-based machine learning model. These models are Random forest, Fuzzy Rules Using Genetic Cooperative-Competitive Learning method (GFS.GCCL), Adaptive-Network-Based Fuzzy Inference System (ANFIS) and Dynamic Evolving Neural-Fuzzy Inference System method (DENFIS). Ensembling is achieved by evaluating the biased weighted aggregation (i.e. adding more weights to the model with a higher prediction score) of predicted data by selected models. The proposed and existing machine learning techniques have been evaluated on drug synergy score data. The comparative analysis reveals that the proposed method outperforms others in terms of accuracy, root mean square error and coefficient of correlation.

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