scholarly journals Mode Analysis of Tectorial Membrane in Cochlea

2021 ◽  
Vol 14 (3) ◽  
pp. 1389-1395
Author(s):  
Toshiaki Kitamura
Keyword(s):  
Mode Analysis ◽  
Tectorial Membrane ◽  
Dispersion Characteristics ◽  
Hearing System

We investigated the dispersion characteristics of the propagation modes that progress on the tectorial membrane (TM). Recent studies have uncovered complex TM behavior and a possibility that TM might play an important role in the hearing system. An interaction between the TM and the fluid induces propagation modes, which are called TM modes. We found that there are several kinds of TM modes and analyzed the direction of the displacement of the TM that is caused by each mode. We also investigated the structural dependency of the angular wavenumber of each mode.

Monte Carlo Algorithms for Moments of Transition Arrays

1988 ◽  
Vol 102 ◽  
pp. 79-81
Author(s):  
A. Goldberg ◽  
S.D. Bloom
Keyword(s):  
Monte Carlo ◽  
State Vector ◽  
Basis Vector ◽  
Collective State ◽  
Dispersion Characteristics ◽  
Dipole Strength ◽  
The Third ◽  
Monte Carlo Algorithms ◽  
Third Moment ◽  
Very High

AbstractClosed expressions for the first, second, and (in some cases) the third moment of atomic transition arrays now exist. Recently a method has been developed for getting to very high moments (up to the 12th and beyond) in cases where a “collective” state-vector (i.e. a state-vector containing the entire electric dipole strength) can be created from each eigenstate in the parent configuration. Both of these approaches give exact results. Herein we describe astatistical(or Monte Carlo) approach which requires onlyonerepresentative state-vector |RV> for the entire parent manifold to get estimates of transition moments of high order. The representation is achieved through the random amplitudes associated with each basis vector making up |RV>. This also gives rise to the dispersion characterizing the method, which has been applied to a system (in the M shell) with≈250,000 lines where we have calculated up to the 5th moment. It turns out that the dispersion in the moments decreases with the size of the manifold, making its application to very big systems statistically advantageous. A discussion of the method and these dispersion characteristics will be presented.

Fine Structure of Interdental Cells in the Mouse Cochlea

1970 ◽  
Vol 28 ◽  
pp. 140-141
Author(s):  
Roberta M. Bruck
Keyword(s):  
Fine Structure ◽  
Electron Microscope ◽  
Young Adult ◽  
Uranyl Acetate ◽  
Ground Substance ◽  
Tectorial Membrane ◽  
Lead Citrate ◽  
Unusual Structure ◽  
Thin Sections ◽  
Collagenous Fibers

An unusual structure in the cochlea is the spiral limbus; this periosteal tissue consists of stellate fibroblasts and collagenous fibers embedded in a translucent ground substance. The collagenous fibers are arranged in vertical columns (the auditory teeth of Haschke). Between the auditory teeth are interdental furrows in which the interdental cells are situated. These epithelial cells supposedly secrete the tectorial membrane.The fine structure of interdental cells in the rat was reported by Iurato (1962). Since the mouse appears to be different, a description of the fine structure of mouse interdental cells' is presented. Young adult C57BL/6J mice were perfused intervascularly with 1% paraformaldehyde/ 1.25% glutaraldehyde in .1M phosphate buffer (pH7.2-7.4). Intact cochlea were decalcified in .1M EDTA by the method of Baird (1967), postosmicated, dehydrated, and embedded in Araldite. Thin sections stained with uranyl acetate and lead citrate were examined in a Phillips EM-200 electron microscope.

Protein structure prediction of human connexin 30 and its mutations in hearing system

2014 ◽  
Vol 3 (5) ◽  
Author(s):  
S. Reiisi ◽  
M. Hashemzade-chaleshtori ◽  
S. Reisi ◽  
H. Shahi ◽  
S. Parchami ◽  
...  
Keyword(s):  
Protein Structure ◽  
Protein Structure Prediction ◽  
Structure Prediction ◽  
Connexin 30 ◽  
Hearing System

Dispersion Characteristics of Multi-Step Open Slow-Wave Systems of Finite Width: Analysis

1997 ◽  
Vol 51 (8) ◽  
pp. 77-84
Author(s):  
L. M. Buzik ◽  
O. F. Pishko ◽  
S.A. Churilova ◽  
O. I. Sheremet
Keyword(s):  
Slow Wave ◽  
Finite Width ◽  
Dispersion Characteristics

Analisa Pola Kegagalan Balok Beton Menggunakan GFRP Bar Tanpa Selimut Beton

2020 ◽  
Vol 24 (1) ◽  
pp. 11-16
Author(s):  
Saddam - Husein ◽  
Rudy Djamaluddin ◽  
Rita Irmawaty ◽  
Kusnadi Kusnadi
Keyword(s):  
Reinforced Concrete ◽  
Concrete Beams ◽  
Concrete Cover ◽  
Steel Reinforcement ◽  
Fiber Reinforced Polymer ◽  
Mode Analysis ◽  
Flexural Capacity ◽  
Reinforced Polymer ◽  
Glass Fiber Reinforced ◽  
Gfrp Bar

SADDAM HUSEIN. Analisa Pola Kegagalan Balok Beton Menggunakan GFRP Bar Tanpa Selimut Beton (dibimbing oleh Rudi Djamaluddin dan Rita Irmawaty) Struktur beton bertulang yang menggunakan tulangan baja pada daerah korosif, menjadi rawan terhadap kerusakan atau penurunan kekuatannya akibat korosi.Korosi pada tulangan baja merupakan salah satu faktor penyebab menurunnya kekuatan struktur beton bertulang. Salah satu material yang dikembangkan mengatasi korosi adalah penggunaan material tulangan GFRP (Glass Fiber Reinforced Polymer). Penelitian ini bertujuan untuk menganalisa kapasitas lentur dan pola kegagalan balok beton tanpa selimut dengan menggunakan material tulangan GFRP bar.   Desain penelitian merupakan eksperimental laboratorium dengan rekapitulasi sebanyak 6 sampel yang terdiri dari 2 Balok beton menggunakan tulangan baja dengan selimut beton, 2 balok beton menggunakan tulangan GFRP bar dengan selimut beton, 2 balok beton menggunakan GFRP bar tanpa selimut beton. Metode pengujian dilakukan dengan dengan pengujian lentur statik monotonik dan Analisis data menggunakan uji kondisi retak awal dan kondisi ultimit.   Hasil penelitian ini menunjukkan bahwa kapasitas lentur pada balok dengan tulangan GFRP bar lebih besar dibandingkan dengan balok tulangan baja dan mampu meningkatkan kapasitas lentur balok dalam menahan beban sebesar 39.76 %, pola kegagalan beton yang terjadi pada balok tulangan baja mengalami kegagalan lentur tekan ditandai dengan retakan yang terjadi pada sisi tertekan dan membentuk retakan tegak dengan sumbu netral beton yang tertekan, sedangkan pada balok beton tulangan GFRP tanpa selimut mengalami kegagalan keruntuhan tekan geser dengan kondisi tulangan berdeformasi (bi-linear) dengan retak miring dan secara tiba-tiba menjalar menuju sumbu netral beton yang tertekan sehingga terjadilah keruntuhan secara tiba-tiba.     SADDAM HUSEIN.Failure mode analysis of concrete Beams Using GFRP rebar Without concrete cover (supervised by Rudi Djamaluddin and Rita Irmawaty)   Reinforced concrete that uses rebar steel in corrosive areas, are prone to damage or decreased strength due to corrosion. Corrosion in the steel reinforcement is one of the factors that decreasing strength of reinforced concrete. One of the materials developed to overcome corrosion is the use of GFRP (Glass Fiber Reinforced Polymer) reinforcement material. This study aims to analyze the flexural capacity and failure mode of concrete beams without concrete cover using material GFRP bar as reinforcement.   The research design was an experimental laboratory with a recapitulation of 6 samples consisting of 2 beams using steel reinforcement with concrete cover.2 concrete beams using reinforcement GFRP bar with concrete cover, 2 beams using GFRP bars without concrete cover. The  research method uses the monotonic static flexure and analyzing the data using the initial crack condition and ultimate conditions test.   The results of the research indicate the flexural capacity of the beams with GFRP bar reinforcement is higher than steel reinforcement beams and can increase 39.76% of the flexural capacity of the beams in holding loads , the failure mode analysis occurs in steel reinforcing beam experiences compressive failure. Failure was characterized  by cracks that occur on the depressing side and form an upright crack with the neutral axis of the compressed concrete, whereas in GFRP reinforced concrete beams without concrete cover, failure of shear compression with conditions of deformed reinforcement (bi-linear) with sloping cracks and suddenly spread towards the neutral axis of the compressed concrete so that there was a sudden collapse.

Application of the ESMACS Binding Free Energy Protocol to a Highly Varied Ligand Dataset: Lactate Dehydogenase A

2019 ◽  
Author(s):  
David Wright ◽  
Fouad Husseini ◽  
Shunzhou Wan ◽  
Christophe Meyer ◽  
Herman Van Vlijmen ◽  
...  
Keyword(s):  
Free Energy ◽  
Surface Area ◽  
Binding Free Energy ◽  
Normal Mode Analysis ◽  
Binding Mode ◽  
Accessible Surface Area ◽  
Solvent Accessible Surface Area ◽  
Mode Analysis ◽  
Energy Calculation ◽  
Accessible Surface

<div>Here, we evaluate the performance of our range of ensemble simulation based binding free energy calculation protocols, called ESMACS (enhanced sampling of molecular dynamics with approximation of continuum solvent) for use in fragment based drug design scenarios. ESMACS is designed to generate reproducible binding affinity predictions from the widely used molecular mechanics Poisson-Boltzmann surface area (MMPBSA) approach. We study ligands designed to target two binding pockets in the lactate dehydogenase A target protein, which vary in size, charge and binding mode. When comparing to experimental results, we obtain excellent statistical rankings across this highly diverse set of ligands. In addition, we investigate three approaches to account for entropic contributions not captured by standard MMPBSA calculations: (1) normal mode analysis, (2) weighted solvent accessible surface area (WSAS) and (3) variational entropy. </div>

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