scholarly journals Protective Effect of Resveratrol on REM Sleep Deprivation Induced Changes in Testicular Functions in Wistar Rats

2020 ◽  
Vol 13 (03) ◽  
pp. 1281-1289
Author(s):  
R. V. Rohit Vishwanath ◽  
S. Saradha ◽  
A. Ruckmani ◽  
A. Sindhana ◽  
R. Vijayashree ◽  
...  
2019 ◽  
Vol Volume 11 ◽  
pp. 179-188 ◽  
Author(s):  
Sarah Mahboubi ◽  
Mohammad Nasehi ◽  
Alireza Imani ◽  
Mitra-Sadat Sadat-Shirazi ◽  
Mohammad-Reza Zarrindast ◽  
...  

Author(s):  
Prakash Selvaraj ◽  
Annadurai Shanmuganathan ◽  
Saravanan Selvaraj ◽  
Babukumar Mani ◽  
Sakthivel Govindaraj ◽  
...  

Objective: The aim of this study is to assess the antioxidant activity of Tephrosia purpurea (TP) in 72 h REM sleep deprivation (RSD). Nowadays, plants are used as therapeutic agents in the wide range of clinical applications. The present investigation is focused on the antioxidant activity of the ethanolic extract of TP on 72 h RSD induced changes in discrete regions of rat brain.Methods: In this study, the plant (leaf) sample collected and ethanolic extraction were done using Soxhlet apparatus. Five groups of Wistar strain male albino rats were used in this study. Each group comprises 6 rats and multiple platform models used for RSD. The values were statistically analyzed using one-way analysis of variance followed by Tukey’s post hoc test for multiple comparison methods. The significance level was kept at p<0.05. The 72 h RSD-induced changes in discrete regions were investigated and verified by measuring the activity of superoxide dismutase (SOD), lipid peroxidation (LPO), catalase (CAT), glutathione peroxidase (GPx), levels of reduced glutathione (GSH), Vitamin C, and Vitamin E in different regions of the rat brain, and plasma corticosterone level.Results: This study confirmed that the leaf extract of TP effectively normalized the increased corticosterone, LPO, SOD, CAT, GPx, and decreased GSH, Vitamin C, and Vitamin E levels as a result of 72 h RSD exposure.Conclusion: The plant examined and possessed remarkable antioxidant activity; hence, the isolation of compounds from this plant leaves may develop a novel and natural phytomedicine for stress-induced diseases.


2021 ◽  
Author(s):  
Sang-Min Kim ◽  
Seungjae Zhang ◽  
Jiwon Park ◽  
Hyun Jae Sung ◽  
Thuy-Duong Thi Tran ◽  
...  

1967 ◽  
Vol 24 (3) ◽  
pp. 851-858 ◽  
Author(s):  
H. W. AGNEW ◽  
WILSE B. WEBB ◽  
ROBERT L. WILLIAMS

2019 ◽  
Vol 109 ◽  
pp. 1563-1568
Author(s):  
Mohammad Nasehi ◽  
Ameneh Shirkhodaei ◽  
Mohaddeseh Ebrahimi-Ghiri ◽  
Mohammad-Reza Zarrindast

SLEEP ◽  
2002 ◽  
Vol 25 (8) ◽  
pp. 37-41 ◽  
Author(s):  
Hiromi Ohno ◽  
Ryo Urushihara ◽  
Hiroyoshi Sei ◽  
Yusuke Morita

1995 ◽  
Vol 268 (6) ◽  
pp. R1456-R1463 ◽  
Author(s):  
T. Porkka-Heiskanen ◽  
S. E. Smith ◽  
T. Taira ◽  
J. H. Urban ◽  
J. E. Levine ◽  
...  

Noradrenergic locus ceruleus neurons are most active during waking and least active during rapid eye movement (REM) sleep. We expected REM sleep deprivation (REMSD) to increase norepinephrine utilization and activate the tyrosine hydroxylase (TH) gene critical for norepinephrine production. Male Wistar rats were deprived of REM sleep with the platform method. Rats were decapitated after 8, 24, or 72 h on small (REMSD) or large (control) platforms or after 8 or 24 h of rebound sleep after 72 h of the platform treatment. During the first 24 h, norepinephrine concentration, measured by high-performance liquid chromatography/electrochemical detection, was lower in the neocortex, hippocampus, and posterior hypothalamus in REMSD rats than in large-platform controls. After 72 h of REMSD, TH mRNA, measured by in situ hybridization, was increased in the locus ceruleus and norepinephrine concentrations were increased. Polygraphy showed that small-platform treatment caused effective and selective REMSD. Serum corticosterone measurement by radioimmunoassay indicated that the differences found in norepinephrine and TH mRNA were not due to differences in stress between the treatments. The novel finding of sleep deprivation-specific increase in TH gene expression indicates an important mechanism of adjusting to sleep deprivation.


Sign in / Sign up

Export Citation Format

Share Document