scholarly journals Medicinal Plants for the Treatment of Postmenopausl Osteoporosis

2019 ◽  
Vol 12 (3) ◽  
pp. 1561-1576
Author(s):  
Evelyn Sharon S ◽  
V. Chitra Chitra
Keyword(s):  
Medicinal Plants ◽  
Fragility Fractures ◽  
Pharmacological Activities ◽  
Treatment Of Osteoporosis ◽  
Traditional Medicines ◽  
Metabolic Bone Disorder ◽  
Metabolic Bone ◽  
Wide Range ◽  
Bone Disorder ◽  
Phytochemical Constituents

Osteoporosis is a metabolic bone disorder which causes bone loss in course of time leading to increasing the fracture risk. The disease is often silent and known only when fractures occur. Both men and women are equally affected. But women are more susceptible to osteoporosis. The main cause of fragility fractures in women is due to the estrogen deficiency. For the treatment of Osteoporosis the potential biological use of traditional medicines have been exposed to logical assessment since synthetic medications are considered to have a wide range of side effects and they lack efficacy. Hence broad research is to be done to examine the therapeutic plants to be utilized as an option for the treatment of Osteoporosis. The present survey work demonstrates the data on medicinal plants with their common name, phytochemical constituents, reported pharmacological activities and their Osteoporotic action.

Comparing the efficacies of bisphosphonates’ therapies for osteoporosis persistence and compliance: A Systematic Review

2021 ◽  
Vol 21 ◽  
Author(s):  
Faisal I. Almohaileb ◽  
Zafar Rasheed
Keyword(s):  
Systematic Review ◽  
Literature Search ◽  
Persistence Length ◽  
Medication Possession Ratio ◽  
Cochrane Library ◽  
Treatment Of Osteoporosis ◽  
Metabolic Bone Disorder ◽  
Metabolic Bone ◽  
Persistence Rates ◽  
Bone Disorder

Objectives: Osteoporosis is the most prevalent metabolic bone disorder worldwide. This review was undertaken to compare the efficacies of bisphosphonates therapies for patient persistence and compliance for the treatment of osteoporosis. Methods: A systematic review was performed in accordance with the available reporting items. MEDLINE and Cochrane library databases were applied for literature searched up to January 2020. All major studies such as prospective, retrospective and reviews articles that examined patient persistence or compliance to bisphosphonates for osteoporosis were included. Results: Literature search found 656 relevant published reports, out of which 87 were included. The 10,712,176 osteoporotic patients were studied for patient persistence and 5,875,718 patients were studied for patient compliances. Analysis of all studied bisphosphonates showed almost similar patterns for patient persistence rates as it was decreased over the time following initial prescription but persistence length was found to be significantly high for alendronate therapy as compared to the other studied bisphosphonates (p<0.001), whereas the length of persistence of all other bisphosphonates (other than alendronate) were almost same (p>0.05). Analysis of patient compliances with etidronate therapy showed the highest percent medication possession ratio (MRP) at 12 months, followed by the MRPs of ibandronate, alendronate, risedronate, and clodronate. Conclusions: This is the first systematic review that shows the comparison of the efficiencies of bisphosphonates for patient persistence and compliance for the treatment of osteoporosis. The data showed that the length of patient persistence was highest for alendronate therapy, whereas patient compliance was highest for etidronate therapy for the treatment of osteoporosis.

Medicinal Inula Species: Phytochemistry, Biosynthesis, and Bioactivities

2021 ◽  
pp. 1-44
Author(s):  
Cheng-Peng Sun ◽  
Zi-Li Jia ◽  
Xiao-Kui Huo ◽  
Xiang-Ge Tian ◽  
Lei Feng ◽  
...  
Keyword(s):  
Secondary Metabolites ◽  
Drug Development ◽  
Scientific Basis ◽  
Pharmacological Properties ◽  
Pharmacological Activities ◽  
Traditional Medicines ◽  
The World ◽  
Phytochemical Constituents ◽  
New Drug Development ◽  
First Time

As a genus of the Asteraceae, Inula is widely distributed all over the world, and several of them are being used in traditional medicines. A number of metabolites were isolated from Inula species, and some of these have shown to possess ranges of pharmacological activities. The genus Inula contains abundant sesquiterpenoids, such as eudesmanes, xanthanes, and sesquiterpenoid dimers and trimers. In addition, other types of terpenoids, flavonoids, and lignins also exist in the genus Inula. Since 2010, more than 300 new secondary metabolites, including several known natural products that were isolated for the first time from the genus Inula. Most of them exhibited potential bioactivities in various diseases. The review aimed to summarize the advance of recent researches (2010–2020) on phytochemical constituents, biosynthesis, and pharmacological properties of the genus Inula for providing a scientific basis and supporting its application and exploitation for new drug development.

Camurati-Engelmann disease (progressive hereditary craniodiaphyseal dysplasia)

1978 ◽  
Vol 48 (1) ◽  
pp. 138-142 ◽  
Author(s):  
John K. Yen ◽  
Robert S. Bourke ◽  
A. John Popp ◽  
Carl R. Wirth
Keyword(s):  
Optic Nerve ◽  
Definitive Treatment ◽  
Content Type ◽  
X Ray ◽  
Metabolic Bone Disorder ◽  
Metabolic Bone ◽  
Bone Disorder ◽  
Craniodiaphyseal Dysplasia ◽  
Engelmann Disease ◽  
Fine Print

✓ In a patient with Camurati-Engelmann disease, orbital and optic nerve decompression resulted in improvement of papilledema. Subsequent x-ray films of the optic canals, however, revealed reconstitution of osseous optic canals bilaterally, and papilledema has returned in one eye. Definitive treatment of this dysplastic metabolic bone disorder rests in the control of rapid abnormal bone formation.

scholarly journals A Review on Natural Plants for Phytochemical Constituents and Pharmacological Activities

2021 ◽  
Vol 11 (2) ◽  
pp. 232-236
Author(s):  
K Muni Raja Lakshmi ◽  
M. Kiran ◽  
K. Sai Prasanna
Keyword(s):  
Medicinal Plants ◽  
Antioxidant Properties ◽  
Volatile Oil ◽  
Calotropis Procera ◽  
Pharmacological Activities ◽  
Antioxidant Agents ◽  
Phytochemical Constituents ◽  
Natural Plants ◽  
Anti Inflammatory ◽  
Anti Fungal

The present review aims for the study of phytoconstituents and pharmacological activities of some natural plants. The traditional medicinal plants have been found to acquire therapeutic activities significantly antimicrobial, anti-inflammatory antibacterial, anti-fungal, antioxidant properties etc. The plant-derived constituents are majorly for the aliments of used skin disease diabetes, bronchitis, asthma, arthritis, dry cough, ulcer and fever. The antimicrobial activity of the following plants like Justicia adathoda, Lantana Camara, Acacia leucophloea, Holoptelea integrifolia, Calotropis Procera, chlorophytum tuberosum, Bombax ceiba, Bacopa monnieri, Wedelia trilobata, Jatropha gossypifolia were obtained from the extraction of either  leaves, stem or flowers by using ethanol, methanol, aqueous, petroleum ether, chloroform. The phytochemical constituents of the extract have been shown the presence of alkaloids, glycosides, cardiac glucosides tannins, proteins, carbohydrates, saponin, quinines, triterpenes, steroids, polyphenolic, volatile oil, phenols, starch sugar, amino acid, resin and organic acids. This study evidenced the possible use of the mentioned plants as a source of natural medicines which are used as an antimicrobial, anti-inflammatory, anti-bacterial, anti-fungal, antioxidant agents. Keywords:  Medicinal plants, Antimicrobial, Anti-inflammatory, Antioxidants.

scholarly journals Antibacterial and Antifungal Activities of Ethiopian Medicinal Plants: A Systematic Review

2021 ◽  
Vol 12 ◽  
Author(s):  
Dereje Nigussie ◽  
Gail Davey ◽  
Takele Beyene Tufa ◽  
Malcolm Brewster ◽  
Belete Adefris Legesse ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Plant Species ◽  
Meta Analysis ◽  
Fungal Species ◽  
Antifungal Activities ◽  
Traditional Medicines ◽  
Antibacterial And Antifungal Activities ◽  
Wide Range ◽  
Antibacterial And Antifungal

Background: Podoconiosis and lymphatic filariasis are the most common causes of lower limb lymphoedema in the tropics. Many sufferers experience frequent painful episodes of acute bacterial infection. Plant based traditional medicines are used to treat infections in many countries and are culturally established in Ethiopia. Ethiopian medicinal plants found to have antibacterial and antifungal activities were reviewed with the aim of increasing information about the treatment of wound infections in patients with lymphoedema.Methods: This study collates data from published articles on medicinal plants with antibacterial and antifungal activities in Ethiopia. A systematic search of Scopus, EMBASE, PUBMED/MEDLINE and Google Scholar was undertaken. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines were followed. The protocol was registered on PROSPERO with registration number CRD42019127471. All controlled studies of in vitro antibacterial and antifungal activities were considered. All articles containing the descriptors published until June 28, 2019 were included. The outcome was measured as percent inhibition of microbial growth. For quality assessment of individual in vitro studies, OECD guidelines and the WHO-Good Laboratory Practice (GLP) handbook were used.Results: Seventy-nine studies met the inclusion criteria. A total of 150 plant species and three compounds had been tested against 42 species of bacteria, while 43 plant species had been tested against 22 species of fungus.Conclusion: Materials derived from several Ethiopian medicinal plants have been shown to have promising activity against a variety of bacteria and fungi. Those derived from Azadiractha indica A. Juss. and Lawsonia inerms L. are the most extensively studied against a wide range of gram-negative and positive bacteria, and fungal species.

scholarly journals Gnathic Bones and Hyperparathyroidism: A Review on the Metabolic Bony Changes Affecting the Mandible and Maxilla in case of Hyperparathyroidism

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Hazim Mahmoud Ibrahem
Keyword(s):  
Parathyroid Hormone ◽  
Primary Hyperparathyroidism ◽  
Giant Cell ◽  
Essential Role ◽  
Osteolytic Lesion ◽  
Ossifying Fibroma ◽  
Brown Tumor ◽  
Metabolic Bone Disorder ◽  
Metabolic Bone ◽  
Bone Disorder

Parathyroid glands secrete the parathyroid hormone that plays an essential role in bone remodeling. Excessive production of parathyroid hormone causes a common metabolic bone disorder known as hyperparathyroidism that is classified into primary, secondary, or tertiary. In hyperparathyroidism, the late bony complication is manifested as a giant cell osteolytic lesion called “brown tumor.” Primary hyperparathyroidism is usually a sporadic disorder, but in minority of cases it occurs in inherited forms, and one of these forms is the hyperparathyroidism-jaw tumor syndrome, which is characterized by primary hyperparathyroidism and ossifying fibroma in the mandible and/or maxilla.

scholarly journals Diabetes Mellitus and Metabolic Bone Disorder.

1999 ◽  
Vol 57 (3) ◽  
pp. 125-134 ◽  
Author(s):  
Kiyoshi Suzuki ◽  
Makoto Takizawa ◽  
Eiji Itagaki ◽  
Hitoshi Ishida
Keyword(s):  
Diabetes Mellitus ◽  
Metabolic Bone Disorder ◽  
Metabolic Bone ◽  
Bone Disorder

scholarly journals Prolyl 3-hydroxylase 1 deficiency causes a recessive metabolic bone disorder resembling lethal/severe osteogenesis imperfecta

2007 ◽  
Vol 39 (3) ◽  
pp. 359-365 ◽  
Author(s):  
Wayne A Cabral ◽  
Weizhong Chang ◽  
Aileen M Barnes ◽  
MaryAnn Weis ◽  
Melissa A Scott ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Metabolic Bone Disorder ◽  
Metabolic Bone ◽  
Bone Disorder
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