Decreased Renal Function Induced by High-Fat Diet in Wistar Rat: The Role of Plasma Angiotensin Converting Enzyme 2 (ACE2)

2019 ◽  
Vol 12 (3) ◽  
pp. 1279-1287
Author(s):  
Ridwan Ridwan ◽  
Rosdiana Natzir ◽  
Haerani Rasyid ◽  
Ilhamjaya Patellongi ◽  
Mochammad Hatta ◽  
...  
Keyword(s):  
Renal Function ◽  
Body Weight ◽  
Body Fat ◽  
High Fat Diet ◽  
Early Stage ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Angiotensin Converting Enzyme 2 ◽  
Obesity Index

Researches on the effects of High Fat Diet (HFD) on decreased renal function with cystatin C (cysC) serum levels biomarker are few and show different findings. Renin Angiotensin System (RAS) plays a key role in controlling renal function and one of the integral components of the RAS is Angiotensin Converting Enzyme 2 (ACE2). Research on the relationship between plasma ACE2 levels with serum cysC levels in animals induced by HFD has not been done. We hypothesize that administration of HFD can cause a decline in early stage renal function through the role of ACE2. 30 male wistar rats aged 10-12 weeks (body weight between 170-220 grams) were randomly divided into 5 groups (6 rats/group): baseline, normal diet for 8 weeks (ND8), ND for 16 weeks (ND16), HFD for 8 weeks (HFD8) and HFD for 16 weeks (HFD16). Body weight and naso-anal length were measured to get the index value of obesity and body fat percentage. Obesity index measured are lee index, rohrer index and TM index. Blood samples obtained by intracardiac for examination of plasma ACE2 levels and serum cysC levels. After 8 and 16 weeks, HFD increases body weight, obesity index and body fat percentage. HFD also increases plasma ACE2 levels and serum cysC levels. Body weight, obesity index and body fat percentage have a positive correlation with plasma ACE2 levels. Plasma ACE2 levels were positively correlated with serum cysC levels. HFD causes a decrease of early stage renal function as evidenced by the increase in serum cysC levels. Plasma ACE2 levels play a role in the pathogenesis of the decline in early stage renal function induced by HFD.

The Influence of Age, Sex and Body Mass Index on the Effectiveness of Brisk Walking for Obesity Management in Adults: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 14 (5) ◽  
pp. 389-407 ◽  
Author(s):  
Leon Mabire ◽  
Ramakrishnan Mani ◽  
Lizhou Liu ◽  
Hilda Mulligan ◽  
David Baxter
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Waist Circumference ◽  
Body Fat ◽  
Fat Mass ◽  
Fat Free Mass ◽  
Body Fat Percentage ◽  
Brisk Walking ◽  
Obesity Management ◽  
Fat Percentage

Background:Brisk walking is the most popular activity for obesity management for adults. We aimed to identify whether participant age, sex and body mass index (BMI) influenced the effectiveness of brisk walking.Methods:A search of 9 databases was conducted for randomized controlled trials (RCTs). Two investigators selected RCTs reporting on change in body weight, BMI, waist circumference, fat mass, fat-free mass, and body fat percentage following a brisk walking intervention in obese adults.Results:Of the 5072 studies screened, 22 met the eligibility criteria. The pooled mean differences were: weight loss, –2.13 kg; BMI, –0.96 kg/m2; waist circumference, –2.83 cm; fat mass, –2.59 kg; fat-free mass, 0.29 kg; and body fat percentage, –1.38%. Meta-regression of baseline BMI showed no effect on changes.Conclusions:Brisk walking can create a clinically significant reduction in body weight, BMI, waist circumference, and fat mass for obese men and women aged under 50 years. Obese women aged over 50 years can achieve modest losses, but gains in fat-free mass reduce overall change in body weight. Further research is required for men aged over 50 years and on the influence of BMI for all ages and sexes.

scholarly journals Probiotics for the Treatment of Docetaxel-Related Weight Gain of Breast Cancer Patients—A Single-Center, Randomized, Double-Blind, and Placebo-Controlled Trial

2021 ◽  
Vol 8 ◽  
Author(s):  
Zhang Juan ◽  
Zhang Qing ◽  
Liang Yongping ◽  
Liyuan Qian ◽  
Wei Wu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Body Weight ◽  
Weight Gain ◽  
Cancer Treatment ◽  
Cancer Patients ◽  
Body Fat ◽  
Breast Cancer Treatment ◽  
Body Fat Percentage ◽  
Breast Cancer Patients ◽  
Fat Percentage

Background: Docetaxel is an important chemotherapy-agent for breast cancer treatment. One of its side-effects is weight gain, which increases the all-cause mortality rate. Considering gut microbiota is one important factor for weight regulation, we hypothesized that probiotics could be potentially used to reduce the docetaxel-related weight gain in breast cancer patients.Methods: From 10/8/2018 to 10/17/2019, 100 breast cancer (Stage I-III) patients underwent four cycles of docetaxel-based chemotherapy were enrolled and randomly assigned to receive probiotics (Bifidobacterium longum, Lactobacillus acidophilus, and Enterococcus faecalis) or placebo (supplementary material of the probiotics capsule) treatment for 84 days with three capsules per time, twice/day. The primary outcome: the changes in body weight and body-fat percentage of the patients were measured by a designated physician using a fat analyzer, and the secondary outcomes: the fasting insulin, plasma glucose, and lipids were directly obtained from the Hospital Information System (HIS); The metabolites were measured using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS); The fecal microbiome was analyzed using bacterial 16S ribosomal RNA (rRNA) gene sequence. All indicators were measured 1 day before the first cycle of docetaxel-based chemotherapy and 21 days after the last cycle of docetaxel-based chemotherapy.Results: Compared with the placebo group, the probiotic group showed significantly smaller changes in body weight (Mean [SD] 0.77 [2.58] vs. 2.70 [3.08], P = 0.03), body-fat percentage (Mean [SD] 0.04 [1.14] vs. 3.86 [11.09], P = 0.02), and low density lipoprotein (LDL) (Mean [SD]−0.05[0.68] vs. 0.39 [0.58], P = 0.002). Moreover, five of the 340 detected plasma metabolites showed significant differences between the two groups. The change of biliverdin dihydrochloride (B = −0.724, P = 0.02) was inverse correlated with weight gain. One strain of the phylum and three strains of the genus were detected to be significantly different between the two groups. Also, the changes of Bacteroides (B = −0.917, P < 0.001) and Anaerostipes (B = −0.894, P < 0.001) were inverse correlated with the change of LDL.Conclusions: Probiotics supplement during docetaxel-based chemotherapy for breast cancer treatment may help to reduce the increase in body weight, body-fat percentage, plasma LDL, and minimize the metabolic changes and gut dysbacteriosis.Clinical Trial Registration:http://www.chictr.org.cn/showproj.aspx?proj=24294, ChiCTR-INQ-17014181.

scholarly journals Obesity is Irreversible Without a Controlled Dietary Regimen in a Murine Model

2019 ◽  
Vol 4 (4) ◽  
pp. 2473011419S0040
Author(s):  
Chris Stauch ◽  
Jesse King ◽  
Morgan Kim ◽  
David Waning ◽  
John Elfar ◽  
...  
Keyword(s):  
Body Fat ◽  
High Intensity ◽  
High Fat Diet ◽  
Exercise Program ◽  
Body Fat Percentage ◽  
Obese Mice ◽  
High Fat ◽  
Fat Percentage ◽  
Mineral Density ◽  
Cardiovascular Training

Category: Diabetes, Hindfoot, Midfoot/Forefoot, obesity Introduction/Purpose: In recent decades, the prevalence of obesity in the United States has increased dramatically. This can be attributed in-part to the high-fat “Western Diet”. Consequentially, the economic burden of obesity to the healthcare system has rapidly increased, accounting for more than 10 percent of all medical spending in America. Furthermore, with regards to orthopedics, obesity has been shown to be a strong risk factor for musculoskeletal pain, injury, and post-operative complications. The purpose of this study was to determine the effects of high intensity cardiovascular training and controlled dietary intake on body weight, body fat percentage (BFP), and bone mineral density (BMD) in obese and non-obese mice. These results will provide a better understanding of how to optimally facilitate weight loss in obese patients. Methods: Following IAUCUC approval, 8 diet-induced obesity (DIO) C57BL/6 mice were obtained along with 6 non-obese C57BL/6 control mice. DIO mice were fed a high-fat diet (60% fat by kcal) ad libitum starting at the age of 6 weeks. Control mice were fed a standard low-fat diet (10% fat by kcal) ad libitum from birth. Starting at the age of 14 weeks, all mice underwent a controlled high intensity cardiovascular training protocol using a treadmill four times per week at 30 minute intervals. This was carried out for seven weeks including a one-week acclimation period. Speed, distance, and time spent running were all constant between groups. Mouse body weights were recorded several times per week throughout the study. Additionally, BFP and BMD were obtained bi-weekly using dual energy X-ray absorptiometry (DEXA) to assess morphophysiological changes longitudinally. Results: Preliminary investigations with a controlled exercise regimen reveal that obese mice, when fed a high-fat diet, continue to gain weight rapidly despite high intensity cardiovascular training whereas control mice maintain their weight. Following the seven-week training period, control mice gained an average of 1.25 g (p=0.41), while DIO mice gained an average of 8.55 g (p<0.001). DIO mice also showed an 8.74% increase in body fat percentage (p=0.002) while control mice showed a 0.51% decrease in body fat percentage (p=0.75). Lastly, BMD was significantly lower in DIO mice compared to controls following the exercise protocol (p<0.05). Conclusion: The results of this study support the hypothesis that a controlled exercise regimen alone is ineffective for facilitating weight loss. In fact, obese mice administered a high-fat diet actually gain weight despite undergoing a rigorous exercise program. Additionally, simple differences in dietary intake have significant effects on body weight, body fat percentage, and bone mineral density. This suggests that while exercise may play a small role in maintaining a normal weight, obesity is irreversible with exercise alone. Obese orthopedic patients should be counseled on dietary modifications before engaging in an exercise program.

scholarly journals Associations between folate intake, body composition, and liver status in healthy adults

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Monika Młodzik-Czyżewska ◽  
Anna Malinowska ◽  
Agata Chmurzynska
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Fatty Liver ◽  
Body Mass ◽  
Body Fat ◽  
Liver Steatosis ◽  
Folate Intake ◽  
Whole Body ◽  
Body Fat Percentage ◽  
Fat Percentage

AbstractA link has recently been underlined between one-carbon metabolism and body weight and body composition, suggesting that folate may account for body mass determination and lipid metabolism. The aim of this study was thus to analyze whether folate intake is associated with body weight, body mass index (BMI), body fat percentage, and liver status.409 subjects aged 20–40 were enrolled in Poznań, Poland from 2016 to 2018. Food intake was assessed using three-day food records. Folate intake was calculated based on food composition tables using the Diet 5.0 program (National Food and Nutrition Institute, Poland). Weight to 0.1 kg and height to 0.01 m were measured using an electronic scale and a stadiometer, respectively. BMI was calculated as body weight in kilograms divided by height in meters squared. Fat mass and lean body mass were determined using whole-body air-displacement plethysmography (BodPod, Cosmed, Italy). Genotyping of rs1801133 (MTHFR) was performed with TaqMan probes. The following biomarkers of liver steatosis were calculated: NAFLD liver fat score (NAFLD-LFS), fatty liver index (FLI), and hepatic steatosis index (HSI). To analyze the associations between folate intake and the measured parameters, we used multiple regression with adjustments for age, sex, and energy intake.The mean body weight was 78.57 ± 18.14 kg, BMI 25.96 ± 5.28 kg/m2, and fat percentage 29.20% ± 10.78%. The median folate intake was 299.3 μg/day. Dietary folate intake was negatively associated with body weight, BMI, and body fat percentage (p < 0.05 for all associations). Folate intake was also associated with fatty liver indices—namely HSI (p < 0.05) and FLI (p < 0.05). There was no association between folate intake and NAFLD-LFS. MTHFR rs1801133 polymorphism was not associated with any of the measured parameters.Our findings suggest that folate intake may affect body weight and composition, as well as liver status. Higher folate intake could have a protective effect against obesity, but further studies are necessary to investigate the mechanism.The authors declare that they have no conflict of interests.This work was supported by the Polish National Science Centre(grants 2014/15/B/NZ9/02134 and 2016/21/N/NZ9/01195).

scholarly journals Regulation of the Body Fat Percentage in Developmental-Stage Rats by Methylxanthine Derivatives in a High-Fat Diet

2006 ◽  
Vol 70 (5) ◽  
pp. 1134-1139 ◽  
Author(s):  
Hiroko INOUE ◽  
Kazuo KOBAYASHI-HATTORI ◽  
Yumi HORIUCHI ◽  
Yuichi OISHI ◽  
Souichi ARAI ◽  
...  
Keyword(s):  
Developmental Stage ◽  
Body Fat ◽  
High Fat Diet ◽  
The Body ◽  
Body Fat Percentage ◽  
High Fat ◽  
Fat Percentage

Effects of Fed- Versus Fasted-State Aerobic Training During Ramadan on Body Composition and Some Metabolic Parameters in Physically Active Men

2012 ◽  
Vol 22 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Khaled Trabelsi ◽  
Kais el Abed ◽  
Stephen R. Stannard ◽  
Kamel Jammoussi ◽  
Khaled M. Zeghal ◽  
...  
Keyword(s):  
Body Composition ◽  
Body Weight ◽  
Body Fat ◽  
Aerobic Training ◽  
Metabolic Parameters ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Physically Active ◽  
Fed State ◽  
Fasted State

The aim of this study was to evaluate the effects of aerobic training in a fasted versus a fed state during Ramadan on body composition and metabolic parameters in physically active men. Nineteen men were allocated to 2 groups: 10 practicing aerobic training in a fasted state (FAST) and 9 training in an acutely fed state (FED) during Ramadan. All subjects visited the laboratory for a total of 4 sessions on the following occasions: 3 days before Ramadan (Bef-R), the 15th day of Ramadan; the 29th day of Ramadan (End-R), and 21 days after Ramadan. During each session, subjects underwent anthropometric measurement, completed a dietary questionnaire, and provided fasting blood and urine samples. Body weight decreased in FAST and FED by 1.9% (p < .001) and 2.6% (p = .046), respectively. Body fat percentage decreased only in FAST by 6.2% (p = .016). FAST experienced an increase in the following parameters from Bef-R to End-R: urine specific gravity (0.64%, p = .012), urea (8.7%, p < .001), creatinine (7.5%, p < .001), uric acid (12.7%, p < .001), sodium (1.9%, p = .003), chloride (2.6%, p < .001), and high-density lipoprotein cholesterol (27.3%, p < .001). Of these parameters, only creatinine increased (5.8%, p = .004) in FED. Creatinine clearance values of FAST decreased by 8.9% (p < .001) and by 7.6% in FED (p = .01) from Bef-R to End-R. The authors conclude that aerobic training in a fasted state lowers body weight and body fat percentage. In contrast, fed aerobic training decreases only body weight. In addition, Ramadan fasting induced change in some metabolic parameters in FAST, but these changes were absent in FED.

scholarly journals The Relationship Between Body Mass Index with Body Fat Percentage of Participants EXPO 2021 Universitas Teuku Umar

2021 ◽  
Vol 2 (1) ◽  
pp. 19
Author(s):  
Suci Eka Putri ◽  
Adelina Irmayani Lubis
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Nutritional Status ◽  
Body Mass ◽  
Body Fat ◽  
Body Height ◽  
The Body ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
The Relationship

Body mass index (BMI) is to monitor nutritional status adults, especially those related to deficiency and overweight. Body fat percentage can describe the risk of degenerative diseases.This study was conducted to measure the relationship between BMI and body fat percentage. Methods An analytical study was conducted to 41 male and 51 female participant from Universitas Teuku Umar. The body weight was measured using scales, whereas the body height was measured using microtoise. The body fat percentage was measured using Karada Scan. The BMI was calculated by dividing the body weight in kilogram divided by body height in meter square. Data was collected from 16-18th February 2021 and analyzed by Pearson’s correlation test. The results showed BMI underweight, normal, and overweight were 10,9, 57,6, and 31,5. High body fat percentage in men were 75,6% and in women were 35,5%. There is a relationship between the nutritional status of the women group and the body fat percentage with p-value is obtained = 0.021. Furthermore, for men, there is no relationship between nutritional status in the men group and the body fat percentage. There is a relationship between nutritional status and body fat percentage in women. Among this population, BMI can still be used to determine body fat percentage

scholarly journals Effect of Eight Weeks of Aerobic Exercise and Garlic Extract Use on the Blood Pressure, Fat Percentage, and Lipid Profile of Patients with Hypertension

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Farhad Towhidi ◽  
Khalid Mohammadzadeh Salamat ◽  
Ali Soroush ◽  
Ali Pourmotabbed
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Aerobic Exercise ◽  
Lipid Profile ◽  
Body Fat ◽  
Garlic Extract ◽  
Exercise Session ◽  
Control Group ◽  
Body Fat Percentage ◽  
Fat Percentage

Background: Obesity is known as one of the most important cardiovascular risk factors. Objectives: This quasi-experimental study was conducted to investigate the effect of an eight-week aerobic exercise and garlic extract use on the blood pressure, fat percentage, and lipid profile of patients with hypertension. Methods: A total of 50 men with a mean age of 53 ± 7.6 years were recruited from among obese patients with blood pressure. They were randomly divided into five groups of aerobic exercise, garlic extract, aerobic exercise plus garlic extract, placebo, and control. The experimental groups underwent aerobic exercise (3 sessions per week, each session for 35 - 60 min with a maximum heart rate of 50 - 75) or garlic extract supplementation (daily use of 6 g) for eight weeks. Blood samples were collected before interventions and 48 h after the last exercise session. Statistical analysis was done by the dependent t-test and ANCOVA. Results: Body weight, body fat percentage, systolic and diastolic blood pressures, and serum LDL significantly reduced in the aerobic exercise, garlic extract, and aerobic exercise plus garlic extract groups compared to the control group (P ≤ 0.05). Aerobic exercise and aerobic exercise plus garlic extract groups showed a significant decrease in total cholesterol level and serum triglyceride and an increase in serum HDL compared to the control group (P ≤ 0.05). Aerobic exercise plus garlic extract group indicated a higher increase in serum HDL and a higher decrease in the body weight, body fat percentage, and serum LDL compared with the control group (P ≤ 0.05). Aerobic exercise plus garlic extract group indicated a higher serum LDL decrease compared to the aerobic exercise group (P ≤ 0.01). Conclusions: Both aerobic exercise and garlic extract seem to be able to improve obesity, lipid profile, and hypertension. However, their concurrent use has no additional effects on the blood pressure control although it mostly influences lipid profile and body composition.

scholarly journals A Study on Somatotype Profiles of the Players in Turkish Bocce National Team

2018 ◽  
Vol 6 (2) ◽  
pp. 28
Author(s):  
Nebahat Eler ◽  
Serdar Eler
Keyword(s):  
Body Weight ◽  
Body Fat ◽  
Body Fat Percentage ◽  
Muscular Force ◽  
Fat Percentage ◽  
Tennis Players ◽  
National Team ◽  
Significant Difference ◽  
Package Program ◽  
The Mean

The aim of this study is to determine the differences between the somatotype profiles and inter-disciplinary somatotype profiles of the Turkish Bocce National Team players. In this study, the mean age of the Turkish Men’s Bocce National Team (n-32) was determined as 21,75±2,35 (years), mean height was 177,62±1,03 (cm), mean body weight was 70,75±0,70 (kg), mean Body Mass Index (BMI) was 22,31±1,06 kg/m2, mean body fat percentage was 16,05±1%. The mean age of the Turkish Women’s Bocce National Team (n-21) was 21,76±2,12 (years), mean height was 165,33±4,24 (cm), mean body weight 55,14±6,36 (kg), mean BMI was 23,22±1,06 kg/m2 mean body fat percentage was 16,05±1%. The Heath-Carter method was used in determining the somatotype profiles of the players. the The statistical analyses in the study were made by using the SPSS 20.0 package program. Somatotype profile in men was determined endomorphic 3,21±0,33; mesomorph 5,04±1,11; ectomorphic 2,20±0,18 as mesomorphic-endomorphic; in women, endomorphic 3,33±1,42; mesomorph 5,08±0,26; ectomorphic 2,07±0,09 as mesomorphic-endomorphic. In this study, the somatotype profiles of the Turkish Bocce National Team players were determined, and a statistically significant difference was detected between the volo and petanque-raffa disciplines in men and women (p<0,05). It is believed that this difference stems from the physical performance requiring more muscular force in volo discipline than the petanque and raffa disciplines. In this study, the somatotype components are similar in tennis players in volo men group and the archers, judo players and Water polo players of the other groups (Men-women petanque and raffa group, Women volo group).

scholarly journals Effects of Fresh Mango Consumption on Blood Glucose, Insulin, and Other Cardiovascular Disease Risk Factors in Overweight and Obese Adults

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 366-366
Author(s):  
Martin Jr Rosas ◽  
Sherry Pinneo ◽  
Celeste O'Mealy ◽  
Changqi Liu ◽  
Mark Kern ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Weight ◽  
Liver Function ◽  
Body Fat ◽  
Disease Risk ◽  
Lipid Profiles ◽  
Body Fat Percentage ◽  
Fat Percentage ◽  
Obese Adults

Abstract Objectives Mangos contain many beneficial dietary compounds including vitamins, minerals, fiber, and are a unique source of certain polyphenols such as mangiferin. Accumulating evidence from in vitro and animal studies have demonstrated that mangos may have antidiabetic, anti-inflammatory, and cardioprotective properties. However, the effects of fresh mango consumption in humans are less clear. The objective of this study was to examine the effects of fresh mango consumption compared to an isocaloric snack (low-fat cookies) on body weight, body fat, blood pressure, glucose, insulin, lipid profiles, liver function enzymes, inflammation, and antioxidant activity in overweight and obese adults. Methods In a randomized crossover design, 27 overweight and obese adults (11 females, 16 males, age 26 ± 8.1 years) consumed 100 Kcal of fresh mangos (166g) or isocaloric low-fat cookies (24g) daily for 12 weeks. Following an overnight fast, a venous blood draw was taken at baseline, week 4, and week 12. Blood samples were analyzed for glucose, insulin, lipid profiles, liver function enzymes, C-reactive protein (CRP), and total antioxidant capacity (TAC). At each visit, body weight, body fat percentage, and blood pressure were measured. Results Twelve weeks of daily mango consumption significantly decreased blood glucose, CRP, and aspartate transaminase (AST) activity while TAC significantly increased (P &lt; 0.05). There were no significant changes in body weight, body fat percentage, blood pressure, insulin, lipid profile, or other liver function enzymes following mango consumption. Cookie consumption significantly increased insulin, CRP, and triglycerides (P &lt; 0.05). Conclusions Mango consumption improved certain chronic disease risk factors including reductions in fasting glucose and inflammation while lipid profiles and anthropometric measurements were not affected. These results suggest that relative to the control snack, daily mango consumption may improve certain risk factors associated with overweight and obesity and should be considered for future research as they contain unique bioactive compounds. Funding Sources This study was funded by the National Mango Board.

Sign in / Sign up

Export Citation Format

Share Document