scholarly journals Decrease of Peripheral Monocyte Relative Number and Mean Platelet Volume in Iron Overloaded Mice

2019 ◽  
Vol 12 (1) ◽  
pp. 443-451
Author(s):  
M. Ghozali ◽  
Suhendra Praptama ◽  
Rini Widyastuti ◽  
Ramdan Panigoro ◽  
Budi Setiabudiawan ◽  
...  
Keyword(s):  
Iron Overload ◽  
Mean Platelet Volume ◽  
Immune Cell ◽  
Cell Number ◽  
High Dose ◽  
Monocyte Count ◽  
Mice Model ◽  
Platelet Volume ◽  
Iron Treatment ◽  
Peripheral Erythrocyte

Iron overload (IO) because of multiple blood transfusion as a definite therapy for hematological disease with chronic and severe anemia has become a major concern. Deleterious complication contributed by chemically reactive deregulated iron may affect cellular homeostasis systemically lead to tissue and organ damage. When this toxicity occurred in blood cells, alteration of peripheral hematological profile concerning erythrocyte, leucocyte, and platelet most likely to be modified and imperatively need to be evidenced. The experimental IO mice model was established by injecting a low and high dose of iron dextran intraperitoneally. Peripheral erythrocyte, leucocyte and platelet indices measured by hematology analyzer were analyzed. A dynamic tendency of leucocyte absolute cell number and differential cell count of low and high dose iron treatment and a significant decrease of differential monocyte count were found. In addition, high dose iron treatment showed a significantly lower mean platelet volume. In conclusion, this study verified that IO impaired the cellular hematological indices by selectively suppress monocyte number addressing that this mononuclear phagocyte was the most affected immune cell. Furthermore, low mean platelet volume following acquired platelet function defect was evidenced. This research provided an animal experimental model that could be used for further study in finding alternative therapeutic targets on the pathophysiology of iron overload diseases, such as thalassemia.

scholarly journals CORRELATION BETWEEN MEAN PLATELET VOLUME AND IRON DEFICIENCY ANEMIA

2019 ◽  
Vol 8 (4) ◽  
Author(s):  
Himanshu Dagor
Keyword(s):  
Iron Deficiency ◽  
Iron Deficiency Anemia ◽  
Peripheral Blood ◽  
Mean Platelet Volume ◽  
Ferritin Level ◽  
Transferrin Saturation ◽  
Deficiency Anemia ◽  
Platelet Volume ◽  
Iron Treatment ◽  
The Mean

Background: Iron inhibits megakaryopoiesis so iron deficiency anemia (IDA) leads to microthrombosis. Iron therapy ameliorates thrombocytosis. In this study, we investigated whether young, active, and large platelets are released into peripheral blood during iron treatment. Mean platelet volume (MPV) was measured as an indicator for the presence of these platelets. Materials and Methods: A total of 80 patients (10 males and 70 females) with IDA were included in this retrospective study. IDA was defined as ferritin level <50 ng/mL with a transferrin saturation <20% or ferritin <15 ng/mL. Daily ferrous sulfate (270 mg iron II sulfate and    80 mg of elemental iron) was given orally to patients. We evaluated retrospectively the hematologic and biochemical parameters prior to and 1 month after iron treatment. Results: the mean ferritin level of the pretreatment group was 6.5 ± 4.0 ng/mL, MPV was 7.9 ± 1.5 fL, hemoglobin (Hb) was 9.8 ± 1.5 g/dL and the mean cellular volume (MCV) was 71.2 ± 7.2 fL. The mean ferritin level of the posttreatment group was 40.3 ± 15.2 ng/mL, MPV was 8.6 ± 2.0 fL, Hb was 12.5 ± 6.6 g/dL, and MCV was 77.6 ± 5.4 fL. The levels of ferritin (P < 0.001), MPV (P < 0.001), MCV (P < 0.001), and Hb (P < 0.001) were significantly higher in the posttreatment group compared to the pretreatment group. Conclusion: There may be an increase in thrombotic events due to hypercoagulability related to microthrombosis during IDA. Even though thrombosis is corrected during iron treatment, the therapy increases the release of large and active thrombocytes into the peripheral blood. Keywords: Iron, iron deficiency anemia, mean platelet volume, thrombocytosis, thrombosis

Klinische und labordiagnostische Parameter bei 21 Hunden mit primärer immunvermittelter Thrombozytopenie

2011 ◽  
Vol 39 (01) ◽  
pp. 17-24 ◽  
Author(s):  
H. J. Schuberth ◽  
R. Mischke ◽  
B. Dircks
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Klinische Relevanz

Zusammenfassung Gegenstand und Ziel: Charakterisierung von klinischen und labordiagnostischen Parametern sowie Therapie und Krankheitsverlauf bei Hunden mit einer angenommenen primären immunvermittelten Thrombozytopenie (pIMT) und Identifizierung möglicher Besonderheiten im Vergleich zu Hunden mit einer sekundären immunvermittelten Thrombozytopenie (sIMT). Material und Methoden: Retrospektive Auswertung von Patientendaten thrombozytopenischer Hunde, bei denen plättchengebundene Antikörper mittels Durchflusszytometrie nachgewiesen wurden. Ergebnisse: Dreizehn der 21 Hunde (62%) mit einer pIMT waren männlich. Das mittlere Alter bei Erstvorstellung betrug 6,6 Jahre (1,6–13,5 Jahre [Median; Minimum–Maximum]). Blutungen, hauptsächlich in Form von Haut- und Schleimhautblutungen, lagen bei 18 Hunden (86%) vor. Neunzehn Hunde (91%) wiesen eine Thrombozytenzahl unter 20000/μl auf. Bei allen Hunden mit einer pIMT ergab sich ein mittleres Thrombozytenvolumen (mean platelet volume, MPV) im oder unter dem Referenzbereich. In nahezu allen Fällen bestand eine gesteigerte Megakaryopoeseaktivität. Der Vergleich zweier Therapieregime (Prednisolon versus Prednisolon und Azathioprin) zeigte keinen signifikanten Unterschied bezüglich der Zeit bis zum Erreichen einer Thrombozytenzahl im Referenzbereich. Zwischen Patienten mit pIMT oder sIMT ließ sich im Hinblick auf Alter und Geschlecht kein signifikanter Unterschied feststellen. Bei Hunden mit einer pIMT waren Thrombozytenzahl und MPV signifikant niedriger und die Megakaryopoeseaktivität signifikant häufiger erhöht. Schlussfolgerung und klinische Relevanz: Bei Hunden, die plättchengebundene Antikörper und zusätzlich eine schwere Thrombozytopenie, ein niedriges MPV und eine gesteigerte Megakaryopoeseaktivität aufweisen, ist eine pIMT naheliegend.

Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

1987 ◽  
Vol 57 (01) ◽  
pp. 55-58 ◽  
Author(s):  
J F Martin ◽  
T D Daniel ◽  
E A Trowbridge
Keyword(s):  
Platelet Count ◽  
Mean Platelet Volume ◽  
Artery Bypass ◽  
Bypass Graft ◽  
Control Group ◽  
Artery Bypass Graft ◽  
Platelet Volume ◽  
Young Males ◽  
The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

Is there any effect of the treatment on mean platelet volume in patients with hypothyroidism and hyperthyroidism?

2015 ◽  
Author(s):  
Yildiz Okuturlar ◽  
Aliye Soylu ◽  
Enver Tekin ◽  
Meral Mert ◽  
Ozlem Harmankaya ◽  
...  
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume

Do We Need Time Adjusted Mean Platelet Volume Measurements?

2010 ◽  
Vol 16 (3) ◽  
pp. 28-31 ◽  
Author(s):  
Marcus D. Lancé ◽  
Rene van Oerle ◽  
Yvonne M. C. Henskens ◽  
Marco A. E. Marcus
Keyword(s):  
Mean Platelet Volume ◽  
Platelet Volume ◽  
Volume Measurements

Effect of homocysteine and mean platelet volume on jenkins modified gensini score in acute myocardial infarction

2019 ◽  
Vol 50 (2) ◽  
Author(s):  
Deddy Hermawan Susanto ◽  
Reginald Leopold Lefrandt ◽  
Agnes Lucia Panda ◽  
Janry Antonius Pangemanan ◽  
Hariyanto Wijaya ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Mean Platelet Volume ◽  
Gensini Score ◽  
Platelet Volume

Evaluation of platelet count and mean platelet volume in type 2 diabetes mellitus

2020 ◽  
Vol 14 (2) ◽  
pp. 34-37
Author(s):  
Priya Bhatt ◽  
◽  
Jignasa Bhalodia ◽  
Mehul Patel ◽  
◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Platelet Count ◽  
Mean Platelet Volume ◽  
Platelet Volume
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