scholarly journals Evaluation of Antidepressant Activity of Ethanolic Extract of Alangium Salvifolium Leaves in Swiss Albino Mice

2017 ◽  
Vol 10 (1) ◽  
pp. 427-433 ◽  
Author(s):  
Shashikumara Shashikumara ◽  
Prathima. C ◽  
Mohammed Sibgatullah
Keyword(s):  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals EFFECT OF ETHANOLIC EXTRACT OF MIMOSA PUDICA ROOT L. ON ACUTE RESTRAINT STRESS-INDUCED ANXIETY AND DEPRESSION IN SWISS ALBINO MICE

2018 ◽  
Vol 11 (10) ◽  
pp. 182 ◽  
Author(s):  
Shashikumara Shashikumara ◽  
Prathima C ◽  
Amrutheswari B
Keyword(s):  
Restraint Stress ◽  
Forced Swim Test ◽  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Phytochemical Analysis ◽  
Mimosa Pudica ◽  
Swiss Albino Mice ◽  
Acute Restraint Stress ◽  
Immobility Time ◽  
Albino Mice

Objective: The present study is undertaken to study the ameliorative effects of ethanolic extract of Mimosa pudica root (EMPR) on stress-induced anxiety and depressive-like behavior in Swiss albino mice.Methods: The animals were subjected to acute restraint stress (ARS) for 7 days, and on the 8th day after drugs administration, the antianxiety effect was evaluated using elevated plus maze (EPM) test. Antidepressant activity was evaluated by animal despair models-forced swim test and tail suspension test. Phytochemical analysis of the extract was also conducted.Results: EMPR (1000 and 2000 mg/kg) and the combined test groups have shown significant antianxiety effects similar to the standard diazepam as indicated by an improved open arm exploratory behavior in EPM model. EMPR also significantly reduced the immobility time in the animal despair models tested.Conclusion: Results suggest that EMPR possesses significant anxiolytic and antidepressant activity in male Swiss albino mice.

scholarly journals Evaluation of antidepressant activity of ethanolic extract of Mimosa pudica in swiss albino mice

2021 ◽  
Vol 7 (4) ◽  
pp. 240-244
Author(s):  
Sanat Udyavar ◽  
Sharath Kumar K ◽  
Mohandas Rai ◽  
H N Gopalakrishna ◽  
Chandrashekar R ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Antidepressant Activity ◽  
Mimosa Pudica ◽  
Swiss Albino Mice ◽  
Albino Mice

Anti inflammatory activity of ethanolic extract of Nymphaea Alba flower in Swiss albino mice

2013 ◽  
Vol 2 (3) ◽  
pp. 474 ◽  
Author(s):  
Jacob Jesurun RS ◽  
Senthilkumaran Jagadeesh ◽  
Somasundaram Ganesan ◽  
Venugopala Rao K ◽  
Madhavi Eerike
Keyword(s):  
Ethanolic Extract ◽  
Inflammatory Activity ◽  
Swiss Albino Mice ◽  
Nymphaea Alba ◽  
Albino Mice ◽  
Anti Inflammatory

scholarly journals Evaluation of antihypercholesterolemic effect using Memecylon edule Roxb. ethanolic extract in cholesterol-induced Swiss albino mice

2015 ◽  
Vol 5 (4) ◽  
pp. 85-91 ◽  
Author(s):  
Palaniselvam Kuppusamy ◽  
R.S. David Paul Raj ◽  
Soundharrajan Ilavenil ◽  
Balasubramanian Kaleeswaran ◽  
Natanamurugaraj Govindan ◽  
...  
Keyword(s):  
Ethanolic Extract ◽  
Swiss Albino Mice ◽  
Albino Mice

scholarly journals Preclinical evaluation of antidepressant activity of aqueous extract of Piper betle leaves in Swiss albino mice

2018 ◽  
Vol 8 (1) ◽  
pp. 143
Author(s):  
Uttara Krishna ◽  
Roopa P. Nayak ◽  
Chaitra S. R.
Keyword(s):  
Aqueous Extract ◽  
Antidepressant Activity ◽  
Natural Antioxidants ◽  
Screening Tests ◽  
Piper Betle ◽  
Force Swim Test ◽  
Indigenous Plants ◽  
Swiss Albino Mice ◽  
Immobility Time ◽  
Albino Mice

Background: There is a growing demand for alternative medicines derived from indigenous plants having natural antioxidants and neuroprotective actions for the treatment of many behavioural disorders such as anxiety and depression. This study was designed to screen antidepressant activity of aqueous extract of Piper betle L. leaf (betel leaf) in Swiss albino mice.Methods: Swiss albino mice of both sexes weighing 25-30grams were used in the present study. Piper betle leaves aqueous extract (PBAE) was administered to the animals at a dose of 100, 200mg/kg body weight orally for 14 days. On the 14th day, after 1 hour of PBAE administration, experiments on force swim test (FST) and tail suspension (TST) were carried out for studying the level of depression. In FST and TST, time of immobility was noted for a period of 5 minutes.Results: Data was analyzed by one-way ANOVA followed by Tukey Kramer’s multiple comparison test at P = 0.05. The results were represented as Mean±SE. PBAE at a dose of 100mg/kg has shown significant antidepressant activity, as evidenced by decrease in the immobility time in both the screening tests of depression.Conclusions: Present results demonstrated that PBAE possess potent antidepressant property. The exact mechanism(s) related to the active compound(s) in Piper betle leaf extract have to be elucidated in future studies.

scholarly journals Anti-Depressant Activity of the Leaves of Zanthoxylum Armatum on Swiss Albino Mice

2020 ◽  
Vol 8 (02) ◽  
pp. 46-50
Author(s):  
Chandrajeet Kumar Yadav ◽  
Kamal Poudel ◽  
Roshan Mehta ◽  
Amit Kumar Shrivastava
Keyword(s):  
Methanolic Extract ◽  
Forced Swim Test ◽  
Antidepressant Drugs ◽  
Antidepressant Activity ◽  
Tail Suspension Test ◽  
Medical Problem ◽  
Mild Stress ◽  
Swiss Albino Mice ◽  
Zanthoxylum Armatum ◽  
Albino Mice

INTRODUCTION Depression is a global mental disorder that has high incidence, high recurrence, and high self-mutilation and suicide rates. Although the antidepressant drugs are available for the treatment, depression still continues to be a major medical problem. The present study was designed to study the anti-depressant activity of the leaves extract of Zanthoxylum armatum using forced swim test and tail suspension test (TST) on Swiss albino mice. MATERIAL AND METHODS The anti-depressant activity of the leaves of Zanthoxylum armatum was assessed using chronic unpredictable mild-stress (CUMS) induced depression in mice. The animals were treated with the methanolic extract of leaves of Zanthoxylum armatum orally at two doses of 100, 200 mg/kg body weight for eight days after (CUMS) induced depression in mice. RESULTS The data were analyzed by one-way ANOVA followed by tukey multiple comparison test. The leaves extract presented significant antidepressant activity in mice (p<0.05), CONCLUSION The results demonstrate that methanolic extract of leaves of Zanthoxylum armatum has got significant antidepressant activity.

scholarly journals Analgesic Effect of Ethanolic Extract of Seeds and Leaves of Coriandrum Sativum on Swiss Albino Mice

2021 ◽  
Vol 9 (02) ◽  
pp. 50-55
Author(s):  
Chandrajeet Kumar Yadav ◽  
Poonam Tiwari ◽  
Roshan Mehta ◽  
Amit Kumar Shrivastava ◽  
Anjan Palikhey
Keyword(s):  
Acetic Acid ◽  
Analgesic Effect ◽  
International Association ◽  
Emotional Experience ◽  
Ethanolic Extract ◽  
Coriandrum Sativum ◽  
Hot Plate ◽  
Plate Method ◽  
Swiss Albino Mice ◽  
Albino Mice

INTRODUCTION: Pain has been described by the International Association for the Study of Pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Although NSAIDS and OPIOIDS are available for the treatment, still pain (chronic) is major problem. The present study was designed to study the analgesic effect of ethanolic extract of Coriandrum sativum using hot plate method and acetic acid induced writhing method in experimental animals (Swiss albino mice). MATERIAL AND METHODS:The analgesic effect of leaves and seeds of Coriandrum sativum was assessed using hot plate method and acetic acid induced writhing method in Swiss albino mice. The animals were treated with the ethanolic extract of leaves and seeds of Coriandrum sativum orally at two doses of 100, 500 mg/kg body weight after electric heat and acetic acid induced pain in mice. RESULTS: The study showed that ethanolic extract of leaves and seeds of Coriandrum sativum presented significant (p<0.05) and (p<0.05) analgesic activity in mice simultaneously. The data were analyzed by one-way ANOVA followed by Dunette's multiple comparison test. The results demonstrate that ethanolic extract of leaves and seeds of Coriandrum sativum has got analgesic potential. CONCLUSION: The results demonstrate that ethanolic extract of leaves and seeds of Coriandrum sativum has got significant analgesic effect.

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