Diagnostic value of body mass index, total lymphocyte count, and hemoglobin level combination to predict severe immunodeficiency in patients with human immunodeficiency virus

2015 ◽  
Keyword(s):  
Body Mass Index ◽  
Human Immunodeficiency Virus ◽  
Body Mass ◽  
Lymphocyte Count ◽  
Diagnostic Value ◽  
Total Lymphocyte Count ◽  
Hemoglobin Level ◽  
Total Lymphocyte ◽  
Immunodeficiency Virus ◽  
Severe Immunodeficiency

scholarly journals Body Mass Index, Haemoglobin, and Total Lymphocyte Count as a Surrogate for CD4 Count in Resource Limited Settings

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Louis Boafo Kwantwi ◽  
Bismark Kwame Tunu ◽  
Daniel Boateng ◽  
Dan Yedu Quansah
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Sensitivity And Specificity ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Cd4 Count ◽  
Traditional Role ◽  
Prognostic Information ◽  
Cross Sectional ◽  
Total Lymphocyte

Background. In view of the lack of evidence on the possibility of an economically viable, easy, and readily available biomarker to substitute the traditional role of CD4 counts in HIV disease progression, this study seeks to investigate the potential use of body mass index (BMI), haemoglobin (Hb), and total lymphocyte count (TLC) as surrogate biomarkers for monitoring the disease. Methods. This cross-sectional study was undertaken at the antiretroviral clinic (ART) of the Bomso Hospital, Kumasi, Ghana. We recruited 384 individuals who were 18 years or older and confirmed HIV seropositive patients. Blood samples were assayed for TLC and Hb. Weight and height were determined and BMI was calculated. Result. At a cut-off point of 12.15 g/dL, Hb had sensitivity and specificity of 73.9% and 56.8%, respectively, whereas BMI had 69.6% and 80.1% sensitivity and specificity, respectively. The sensitivity and specificity were also 100% among the studied participants at a cut-off point of 1200 mm−3 for TLC. There was a significant positive correlation between CD4 count and Hb (rho 0.262, p=0.0001), BMI (rho 0.301, p=0.0001), and TLC (rho 0.834, p=0.0001). Conclusion. The study demonstrates that TLC, Hb, and BMI may provide some useful prognostic information independent of that provided by CD4 count.

scholarly journals Human immunodeficiency virus in institutionalized elderly people

2016 ◽  
Vol 134 (6) ◽  
pp. 528-533
Author(s):  
Milton Luiz Gorzoni ◽  
Sueli Luciano Pires ◽  
Lilian de Fátima Costa Faria ◽  
Márcia Regina Valadares Aguado ◽  
Miriam Carmen Santana
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B ◽  
Lymphocyte Count ◽  
Antiretroviral Drugs ◽  
Total Lymphocyte Count ◽  
Hiv Positive ◽  
Hiv Diagnosis ◽  
Total Lymphocyte ◽  
Hospital Infection Control ◽  
Immunodeficiency Virus

ABSTRACT CONTEXT AND OBJECTIVE: A search in the SciELO and PubMed databases showed few studies on human immunodeficiency virus (HIV) positive individuals in long-term care institutions (LTCIs), thus prompting the present study. The aim of this study was to ascertain whether there were any HIV-positive individuals in LTCIs for the elderly. DESIGN AND SETTING: Cross-sectional study in which the Hospital Infection Control Committee (HICC) of a 405-bed LTCI was consulted. METHODS: The medical records of 405 individuals interned in the LTCI who had been tested for HIV infection were requested for analysis of the following variables: [1] age and gender; [2] length of stay at LTCI (months); [3] causes and diagnoses on admission to LTCI according to International Classification of Diseases, 10th edition; [4] date of HIV diagnosis; [5] seropositivity for syphilis and hepatitis B and C viruses; [6] medications used at last prescription in medical file; and [7] mean CD4 lymphocyte count based on: total lymphocyte count/6 and total lymphocyte count x 0.8 x 0.2 or 0.3. RESULTS: Four men were HIV-positive, with mean age 71.2 ± 8.6 years, LTCI stay 74.2 ± 38.1 months and length of HIV diagnosis 24.5 ± 17 months (confirmed by HICC standard screening). Three had stroke sequelae; one, dementia syndrome; two, seropositivity for syphilis; two, hepatitis B and one, hepatitis C. The main drugs used were lamivudine, zidovudine, lopinavir, ritonavir, levothyroxine, omeprazole, ranitidine, lactulose and risperidone. The estimated CD4 count was 341 ± 237/mm3. CONCLUSIONS: HIV-positive individuals are present in LTCIs, diagnosable through serological screening and treatable with antiretroviral drugs.

scholarly journals Korelasi Total Lymphocyte Count terhadap CD4 pada anak dengan Infeksi Human Immunodeficiency Virus

Sari Pediatri ◽  
2016 ◽  
Vol 15 (2) ◽  
pp. 81
Author(s):  
Aulia Fitri Swity ◽  
Djatnika Setiabudi ◽  
Herry Garna
Keyword(s):  
Human Immunodeficiency Virus ◽  
Lymphocyte Count ◽  
Total Lymphocyte Count ◽  
Total Lymphocyte ◽  
Immunodeficiency Virus ◽  
Hiv Aids

Latar belakang.Epidemi infeksi human immunodeficiency virus (HIV) merupakan tantangan besar dalam permasalahan kesehatan di dunia. Di Indonesia, jumlah kasus HIV/AIDS anak semakin meningkat tiap tahunnya. Pemantauan jumlah CD4 dapat membantu memutuskan dimulainya pemberian terapi anti- CD4 dapat membantu memutuskan dimulainya pemberian terapi antiretroviral/ARV, tetapi pemeriksaannya mahal dan tidak selalu tersedia di sarana kesehatan. Total lymphocyte count (TLC) diajukan sebagai panduan alternatif selain jumlah CD4 pada keadaan sarana kesehatan yang terbatas. Tujuan. Menentukan korelasi TLC dengan jumlah CD4, dan menentukan jumlah CD4 berdasarkan pemeriksaan TLC pada anak HIV.Metode. Penelitian potong lintang berupa observasional analitik, pengambilan data secara retrospektif rekam medis anak HIV yang dirawat inap di Departemen/SMF Ilmu Kesehatan Anak dan rawat jalan di Klinik Teratai Rumah Sakit Dr. Hasan Sadikin, Bandung. Dilakukan analisis regresi linier pada faktor-faktor yang berhubungan bermakna dengan CD4 untuk menentukan korelasi TLC dengan CD4, serta nilai hitung CD4 dari TLC. Kemaknaan ditentukan berdasarkan nilai p<0,05. Hasil.Subjek penelitian 67 anak HIV, terdiri dari 35 (52%) laki-laki dan 32 (48%) perempuan. Rentang jumlah CD4 berkisar antara 6–3.094 mm3, rerata 444,3 mm3(SD 536,3), median 241 mm3,dan rentang jumlah TLC antara 525–10.738, rerata 3.352,4 (SD 2.020,4), median 2.898. Analisis regresi menunjukkan hubungan linier antara jumlah CD4 sebagai variabel tergantung (Y) dan TLC sebagai variabel bebas (X) menggunakan persamaan Y= -158,209+0,180X. Didapatkan korelasi kuat antara TLC dan jumlah CD4 (r=0,68; p<0,001). Kesimpulan.Terdapat hubungan positif antara jumlah limfosit dan jumlah CD4. Jumlah CD4 pada pasien HIV anak dapat diperkirakan dari jumlah limfosit. Diperlukan penelitian lebih lanjut untuk menentukan cut off point TLC dalam inisiasi ARV

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