Field screening of murmurs and arrhythmias in performance Argentine polo ponies

2021 ◽  
Vol 20 (1) ◽  
pp. 147-162
Author(s):  
Pemika Issariyodom ◽  
◽  
Angkana Kidtiwong ◽  
Kannika Na Lampang ◽  
Wanpitak Pongkan ◽  
...  
Keyword(s):  
Athletic Performance ◽  
High Intensity ◽  
Heart Diseases ◽  
Cardiac Auscultation ◽  
Field Screening ◽  
Physiological Conditions ◽  
Cardiac Abnormalities ◽  
High Workload ◽  
Cardiac Disorders ◽  
To Receive

Polo is a high-intensity sport, and the horses who participate in it are known to receive a high workload on their hearts. Having cardiac disorders can impair their athletic performance or even increase the risk of collapsing during the game. In sport horses, murmurs and arrhythmias are commonly-found physiological conditions; nevertheless, many of them are related to heart diseases. Though numerous studies on murmurs and arrhythmias have been done among several kinds of horses, the information in polo horses is still limited. This study was done to investigate the prevalence of murmurs and arrhythmias in performance Argentine polo ponies by field screening with fast and convenient methods. A hundred and ninety-six performance Argentine polo ponies (162 mares and 34 geldings) with ages between 6 – 20 years old were included in this study. Cardiac auscultation with a simple stethoscope was done to detect and grade murmurs, and electrocardiography with an iPhone ECG (electrocardiogram) recorder was done at the same time to find if there were any arrhythmias. The results showed 98 ponies (50%) that probably had cardiac abnormalities, these could be divided into 61 ponies (31.1%) with only murmurs, 18 ponies (9.2%) with only arrhythmias, and 19 ponies (9.7%) with both murmurs and arrhythmias. In conclusion, murmurs and arrhythmias were found frequently by field screening of this study; cardiac examination should not be overlooked, and those ponies with murmurs and/or arrhythmias should be examined further to determine whether they were pathologic or not.

scholarly journals MicroRNAs in Cardiac Autophagy: Small Molecules and Big Role

Cells ◽  
2018 ◽  
Vol 7 (8) ◽  
pp. 104 ◽  
Author(s):  
Teng Sun ◽  
Meng-Yang Li ◽  
Pei-Feng Li ◽  
Ji-Min Cao
Keyword(s):  
Cardiac Fibrosis ◽  
Heart Diseases ◽  
Critical Role ◽  
Transcriptional Gene Silencing ◽  
Close Link ◽  
Post Transcriptional Gene Silencing ◽  
Evolutionarily Conserved ◽  
Cardiac Disorders ◽  
Cellular Components

Autophagy, which is an evolutionarily conserved process according to the lysosomal degradation of cellular components, plays a critical role in maintaining cell homeostasis. Autophagy and mitochondria autophagy (mitophagy) contribute to the preservation of cardiac homeostasis in physiological settings. However, impaired or excessive autophagy is related to a variety of diseases. Recently, a close link between autophagy and cardiac disorders, including myocardial infarction, cardiac hypertrophy, cardiomyopathy, cardiac fibrosis, and heart failure, has been demonstrated. MicroRNAs (miRNAs) are a class of small non-coding RNAs with a length of approximately 21–22 nucleotides (nt), which are distributed widely in viruses, plants, protists, and animals. They function in mediating the post-transcriptional gene silencing. A growing number of studies have demonstrated that miRNAs regulate cardiac autophagy by suppressing the expression of autophagy-related genes in a targeted manner, which are involved in the pathogenesis of heart diseases. This review summarizes the role of microRNAs in cardiac autophagy and related cardiac disorders. Furthermore, we mainly focused on the autophagy regulation pathways, which consisted of miRNAs and their targeted genes.

scholarly journals Atorvastatin in the Treatment of Hypercholesterolemia in High Risk Cardiovascular Patients in Bangladesh

2012 ◽  
Vol 2 (1) ◽  
pp. 5-13
Author(s):  
Hajera Mahtab ◽  
Razia Sultana Mahmud ◽  
Kukkum Pervin ◽  
Md Javed Sobhan
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Heart Diseases ◽  
Density Lipoprotein ◽  
Statin Treatment ◽  
Effective Control ◽  
Coronary Heart Diseases ◽  
Baseline Visit ◽  
Risk Patients ◽  
To Receive

Background and aim: This study was to evaluate atorvastatin in the management of hypercholesterolemia of cardiovascular risk patients as well as the implication of National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III guidelines in Bangladesh.Methods: A total 1685 patients aged 28 years or older who had evidence of hypercholesterolemia with or without Coronary Heart Diseases (CHD) and cardiovascular risk factors were assigned to receive atorvastatin for 2 months. The change of fasting LDL at baseline visit and after 2 months of the statin treatment was measured.Results: One thousand six hundred (95%) patients out of 1685 who were assigned to receive atorvastatin with TLC were found significant mean reduction (26.1%?) in their LDL levels from baseline visit. Triglycerides and total cholesterols were also reduced (16.6% ? and 21.6% ? respectively) wheras high-density lipoprotein was increased (16.5% ?) significantly. LDL of 23% patients was decreased more than 30 mg/dl after 2 months of atorvastatin treatment. Fifty nine percent of the patients reached the treatment goal of reducing LDL > 20 mg/dl.Conclusion: Atorvastatin would achieve a good effective control in the management of hypercholesterolemic patients with or without CHD and risk factors following the guidelines of US NCEP ATP III. DOI: http://dx.doi.org/10.3329/birdem.v2i1.12354 Birdem Med J 2012; 2(1) 5-13

The relationship between treatment intensity and characteristics of patients with early-stage breast cancer.

2020 ◽  
Vol 38 (29_suppl) ◽  
pp. 125-125
Author(s):  
Jeffrey Franks ◽  
Nicole Caston ◽  
Courtney Williams ◽  
Andres Azuero ◽  
Monica S. Aswani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Clinical Trials ◽  
High Intensity ◽  
Early Stage ◽  
Standard Of Care ◽  
Early Stage Breast Cancer ◽  
Treatment Intensity ◽  
Low Intensity ◽  
Her2 Breast Cancer ◽  
To Receive

125 Background: Clinical trials are used to generate standard-of-care, yet often do not reflect patient populations treated in real-world settings. Elderly patients or patients of color who are often underrepresented in trials, which may impact what types of treatments are prescribed. This study examines how patient characteristics are associated with treatment intensity in early stage breast cancer. Methods: This retrospective cross-sectional study included women with a stage I-III breast cancer from American Society of Clinical Oncology’s CancerLinQ database treated by chemotherapy from 2005-2019. Seven standard-of-care regimens were characterized by intensity. For patients with ER+/- HER2- breast cancer, low-intensity regimens were Taxol and Cyclophosphamide or Adriamycin and Cyclophosphamide; while Taxol, Adriamycin, and Cyclophosphamide was considered high intensity. For patients with HER2+ breast cancer, the low intensity regimen was Taxol and Herceptin; while Adriamycin and Cyclophosphamide followed by Taxol and Herceptin; Taxol, Carboplatin, and Herceptin; or Taxol, Carboplatin, Herceptin, and Pertuzumab were considered high intensity. A model estimating the likelihood of intensity was calculated using log-binomial regression, in order to produce relative risks. The models were adjusted for patient demographics and cancer stage. Results: Of 24,383 patients, 51% had ER+HER2-, 20% ER-HER2-, and 29% HER2+ breast cancer. Most patients were White (60%), age 40-69 (80%), had stage II breast cancer (39%), and received higher intensity treatment (65%). Adjusted for the other covariates, patient who were Black were more likely to receive high-intensity treatment than patients who were White (61% vs 58%; RR 1.05, 95%CI 1.02-1.06. Additionally, older adults were more likely to receive low-intensity treatment, with 42% of patients over 70 receiving low intensity treatment, and 29% of patients between the ages 40 and 69 received low intensity treatment (RR 1.5, 95% CI 1.44 -1.54). Conclusions: Differences in treatment intensity were observed for patients with differing demographic characteristics. Further research is needed to determine lack of representation in clinical trials impacts on prescribing patterns, regimen intensity, and survival.

A depolarizing inhibitory postsynaptic potential activated by synaptically released γ-aminobutyric acid under physiological conditions in rat hippocampal pyramidal cells

1988 ◽  
Vol 66 (8) ◽  
pp. 1100-1102 ◽  
Author(s):  
Paul Perreault ◽  
Massimo Avoli
Keyword(s):  
High Intensity ◽  
Pyramidal Neurons ◽  
Pyramidal Cells ◽  
Rat Hippocampus ◽  
Aminobutyric Acid ◽  
Afferent Stimulation ◽  
Inhibitory Postsynaptic Potential ◽  
Physiological Conditions ◽  
Ca1 Pyramidal Neurons ◽  
Postsynaptic Potential

We report that CA1 pyramidal neurons of the rat hippocampus respond to high intensity afferent stimulation by generating a late depolarizing potential that typically occurs between the early (fast) inhibitory postsynaptic potential (IPSP) and the late (slow) IPSP. This potential is reminiscent of the response seen after the application of 4-aminopyridine and can be blocked by bicuculline, indicating that GABAA receptors are involved in its generation.

Psychological Effects of a Self-Sufficiency Model Based on Urge System

2010 ◽  
Vol 14 (7) ◽  
pp. 877-884 ◽  
Author(s):  
Teruaki Ando ◽  
◽  
Masayoshi Kanoh
Keyword(s):  
Interaction Effect ◽  
Autonomous System ◽  
Load Condition ◽  
Psychological Effects ◽  
Simulation Experiments ◽  
Physiological Conditions ◽  
Model Based ◽  
Self Sufficiency ◽  
Physiological Load ◽  
To Receive

In recent years, robots to coexist with humans have been developed. Their ability to communicate is indispensable for their coexistence with humans, so studies on the interaction between humans and robots are important. This paper proposes a model of the selfsufficiency system of a robot, in which we apply the urge system to the autonomous system of emotion. In this model, a robot expresses its changing psychological and physiological conditions (physiological load condition) and conveys them sensitively to the user. This is expected to result in a mental interaction effect between the user and the agent. We carry out simulation experiments on this model and verify the psychological interaction between the software robot (agent) and the user. As a result of these experiments, it is recognized that the agents with the ability to properly express physiological load among those with this model implemented have a tendency to receive higher evaluations from their users.

scholarly journals Detection of pathological heart murmurs by feature extraction of phonocardiogram signals

2017 ◽  
Vol 2 (4) ◽  
Author(s):  
Antra Ganguly ◽  
Manisha Sharma
Keyword(s):  
Heart Diseases ◽  
Cost Effective ◽  
Heart Sounds ◽  
Cardiac Auscultation ◽  
Non Invasive ◽  
Hearing Ability ◽  
Detection And Diagnosis ◽  
Electrocardiogram Ecg ◽  
Pcg Signals ◽  
Heart Condition

Cardiac auscultation can be perceived as method of determining the human heart condition by listening to the heart sounds. These heart sounds contain vital information related to a person’s heart condition. Any departure from the normal cardiac auscultation readings in terms of presence of additional heart sounds is indicative of an unhealthy heart. The use of Phonocardiogram (PCG)signals (i.e. the electronic recording of heart sounds) completely dismisses the limitation of relying solely on the physician’s hearing ability. At the same time, they provide with a high-fidelity representation of the heart sounds in the most cost-effective way as compared to the methods like Electrocardiogram (ECG). In this paper, a method of detection of heart ailments by extracting the features of PCG signals is proposed. The normal heart sounds, gallop rhythms and the most common pathological murmurs have been used for analysis. By analyzing these signals, early detection and diagnosis of heart diseases can be done reliably. This will not only confirm health and longevity by early diagnosis and pin-pointed prognosis, but will also be economically suitable for those who can hardly afford tests like ECG. It can also be practicable in the case of infants wherein the other non-invasive diagnosis techniques like ECG fail.

scholarly journals Paraneoplastic hypereosinophilia in a patient with peripheral T cell lymphoma, not otherwise specified

2019 ◽  
Author(s):  
Minodora Desmirean ◽  
Dalma Deak ◽  
Ioana Rus ◽  
Delia Dima ◽  
Sabina Iluta ◽  
...  
Keyword(s):  
T Cell ◽  
Blood Smear ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma ◽  
Oncological Patient ◽  
Physiological Conditions ◽  
Not Otherwise Specified ◽  
Complex Approach ◽  
To Receive

Under normal physiological conditions, the bone marrow (BM) will have between 1% and 6% eosinophils, translating into a peripheral count of 0.05 – 0.5 x109 /L eosinophils in the blood smear. This process is coordinated by transcription factors with specific roles in differentiation and activation. Secondary eosinophilia may be a paraneoplastic syndrome, related to the presence of a subsequent malignancy, as presented in this case report. Such paraneoplastic manifestations should be addressed properly in order for the patient to receive the best treatment of choice. Even if eosinophilia was associated with B-cell malignancies before, this is a report associating this symptom to a peripheral T-cell lymphoma, not other specified, thus emphasizing the importance of a complex approach for the management of the oncological patient.  

scholarly journals The Properties of Water and their Applications for Training

2014 ◽  
Vol 44 (1) ◽  
pp. 237-248 ◽  
Author(s):  
Lorena Torres-Ronda ◽  
Xavi Schelling i del Alcázar
Keyword(s):  
Hydrostatic Pressure ◽  
Physical Properties ◽  
Athletic Performance ◽  
High Intensity ◽  
Biological Effects ◽  
Aquatic Medium ◽  
Physiological Adaptations ◽  
Neuromuscular Systems ◽  
The Individual ◽  
Stimulation Of

Abstract The biological effects of immersion in water, which are related to the fundamental principles of hydrodynamics, may be beneficial in certain training contexts. The effects and physical properties of water, such as density, hydrostatic pressure and buoyancy are highly useful resources for training, when used as a counterbalance to gravity, resistance, a compressor and a thermal conductor. Not only does the aquatic medium enable a wider range of activities to be used in a context of low joint impact, but it also constitutes a useful tool in relation to sports rehabilitation, since it allows the athlete to return to training earlier or to continue with high-intensity exercise while ensuring both low joint impact and greater comfort for the individual concerned. Moreover, this medium enables the stimulation of metabolic and neuromuscular systems, followed by their corresponding physiological adaptations allowing both to maintain and improve athletic performance. Hydrotherapy can also play a beneficial role in an athlete’s recovery, helping to prevent as well as treat muscle damage and soreness following exercise.

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