scholarly journals Assessing Effect of Infection in Each Season of the Year on Recurrence of Psoriasis: Using the Time-Dependent Coefficient Rates Model for Recurrent Event Data

2015 ◽  
Vol 2 (3) ◽  
Author(s):  
Freshteh Osmani
Keyword(s):  
Recurrent Event ◽  
Time Dependent ◽  
Event Data ◽  
Recurrent Event Data

scholarly journals Regression splines in the time-dependent coefficient rates model for recurrent event data

2008 ◽  
Vol 27 (28) ◽  
pp. 5890-5906 ◽  
Author(s):  
Leila D. Amorim ◽  
Jianwen Cai ◽  
Donglin Zeng ◽  
Maurício L. Barreto
Keyword(s):  
Recurrent Event ◽  
Time Dependent ◽  
Regression Splines ◽  
Event Data ◽  
Recurrent Event Data

Additive rates model for recurrent event data with intermittently observed time-dependent covariates

2021 ◽  
Vol 30 (10) ◽  
pp. 2239-2255
Author(s):  
Tianmeng Lyu ◽  
Xianghua Luo ◽  
Chiung-Yu Huang ◽  
Yifei Sun
Keyword(s):  
Recurrent Events ◽  
Epidemiologic Study ◽  
Recurrent Event ◽  
Time Dependent ◽  
Occurrence Rate ◽  
Absolute Difference ◽  
Event Data ◽  
Recurrent Event Data ◽  
Time Dependent Covariates

Various regression methods have been proposed for analyzing recurrent event data. Among them, the semiparametric additive rates model is particularly appealing because the regression coefficients quantify the absolute difference in the occurrence rate of the recurrent events between different groups. Estimation of the additive rates model requires the values of time-dependent covariates being observed throughout the entire follow-up period. In practice, however, the time-dependent covariates are usually only measured at intermittent follow-up visits. In this paper, we propose to kernel smooth functions involving time-dependent covariates across subjects in the estimating function, as opposed to imputing individual covariate trajectories. Simulation studies show that the proposed method outperforms simple imputation methods. The proposed method is illustrated with data from an epidemiologic study of the effect of streptococcal infections on recurrent pharyngitis episodes.

scholarly journals Penalized survival models for the analysis of alternating recurrent event data

Biometrics ◽  
2019 ◽  
Vol 76 (2) ◽  
pp. 448-459 ◽  
Author(s):  
Lili Wang ◽  
Kevin He ◽  
Douglas E. Schaubel
Keyword(s):  
Recurrent Event ◽  
Survival Models ◽  
Event Data ◽  
Recurrent Event Data

Semiparametric methods for regression analysis of panel count data and mixed panel count data

2017 ◽  
Author(s):  
◽  
Guanglei Yu
Keyword(s):  
Regression Analysis ◽  
Simulation Study ◽  
Count Data ◽  
Recurrent Events ◽  
Recurrent Event ◽  
Mixed Data ◽  
Panel Count Data ◽  
Event Data ◽  
Recurrent Event Data ◽  
Recurrent Event Process

[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Recurrent event data and panel count data are two common types of data that have been studied extensively in event history studies in literature. By recurrent event data, we mean that subjects are observed continuously in the follow-up study and thus occurrence times of recurrent events of interest are available. For panel count data, subjects are monitored periodically at discrete observation times and thus only numbers of recurrent events between two subsequent observations are recorded. In addition, one may face mixed panel count data in practice, which are the mixture of recurrent event data and panel count data. They arise when each study subject may be observed continuously during the whole study period, continuously over some study periods and at some time points otherwise, or only at some discrete time points. That is, these mixed data provide complete or incomplete information on the recurrent event process over different time periods for different subjects. It is well-known that in panel count data, the observation process may carry information on the underlying recurrent event process and the censoring may also be dependent in practice. Under such circumstance, the first part of this dissertation will discuss regression analysis of panel count data with informative observations and drop-outs. For the problem, a general means model is presented that can allow both additive and multiplicative effects of covariates on the underlying recurrent event process. In addition, the proportional rates model and the accelerated failure time model are employed to describe the covariate effects on the observation process and the dropout or follow-up process, respectively. For estimation of regression parameters, some estimating equation-based procedures are developed and the asymptotic properties of the proposed estimators are established. In addition, a resampling approach is proposed for the estimation of the covariance matrix of the proposed estimator and a model checking procedure is also provided. The results from an extensive simulation study indicate that the proposed methodology works well for practical situations and it is applied to a motivated set of real data from the Childhood Cancer Survivor Study (CCSS) given in Section 1.1.2.2. In the second part of this dissertation, we will consider regression analysis of mixed panel count data. One major problem in the statistical inference on the mixed data is to combine these two different types of data structures. Since panel count data can be viewed as interval-censored recurrent event data with exact occurrence times of events of interest unobserved or missing, they may be augmented by filling in those missing data by imputation. Then the mixed data can be converted to recurrent event data on which the existing statistical inference method can be easily implemented. Motivated by this, a multiple imputation-based estimation approach is proposed. A simulation study is conducted to study the finite-sample properties of the proposed methodology and it shows that the proposed method is more efficient than the existing method. Also, an illustrative example from the CCSS is provided. The third part of this dissertation still considers regression analysis of mixed panel count data but in the presence of a dependent terminal event, which precludes further occurrence of either recurrent events of interest or observations. For this problem, we present a marginal modeling approach which acknowledges the fact that there will be no more recurrent events after the terminal event and leaves the correlation structure unspecified. To estimate the parameters of interest, an estimating equation-based procedure is developed and the inverse probability of survival weighting technique is used. Asymptotic properties of proposed estimators are also established and finite-sample properties are assessed in a simulation study. We again apply this proposed methodology to the CCSS. In the last part of this dissertation, we will discuss some work directions of the future research.

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