A Two-Year Study of the Growth-Promoting Effect and Safety of Human Growth Hormone for Short Stature Due to Intrauterine Growth Retardation

1999 ◽  
Vol 8 (2) ◽  
pp. 67-75 ◽  
Author(s):  
Masamichi Ogawa ◽  
Hitoshi Kohno ◽  
Yoshikazu Nishi
Keyword(s):  
Growth Hormone ◽  
Short Stature ◽  
Human Growth Hormone ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Human Growth ◽  
Promoting Effect ◽  
Intrauterine Growth ◽  
Growth Promoting

GROWTH RESPONSES TO HUMAN GROWTH HORMONE IN PATIENTS WITH INTRAUTERINE GROWTH RETARDATION

1975 ◽  
Vol 30 (2) ◽  
pp. 113-114
Author(s):  
THOMAS P. FOLEY ◽  
ROBERT G. THOMPSON ◽  
MAURICE SHAW ◽  
ALICE BAGHDASSARIAN ◽  
S. PETER NISSLEY ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Human Growth ◽  
Growth Responses ◽  
Intrauterine Growth

Sustained Effect of Human Growth Hormone Therapy on Children With Intrauterine Growth Retardation

PEDIATRICS ◽  
1979 ◽  
Vol 63 (5) ◽  
pp. 731-735
Author(s):  
Roberto Lanes ◽  
Leslie P. Plotnick ◽  
Peter A. Lee
Keyword(s):  
Growth Hormone ◽  
Treatment Period ◽  
Human Growth Hormone ◽  
Growth Retardation ◽  
Growth Rates ◽  
Intrauterine Growth Retardation ◽  
Human Growth ◽  
Hormone Deficiency ◽  
Recent Measurement ◽  
Intrauterine Growth

Previous studies have not clarified whether human growth hormone (HGH) therapy can significantly increase the height of patients with intrauterine growth retardation (IUGR). To determine whether the initial increase in growth rate is sustained through subsequent treatiment, 19 prepubertal patients who had IUGR were treated with HGH Ten of them received a second treatment course. Growth rates (in centimeters per year) were 4.8 ± 1.4 ( mean ± SD) for the pretreatment period, 7.6 ± 2.3 for the first treatment period, 4.2 ± 2.5 for the interval between treatments, 5.9 ± 1.4 for the second treatment period, and 4.3 ± 2.6 for the posttreatment period. Growth rates for the two treatment periods were significantly greater than for the periods before, interval between, and posttreatment. Height expressed as the number of standard deviations below the mean for age increased significantly between the onset of treatment and the most recent measurement. These data indicate that HGH has a sustained positive effect on increasing growth rates in children with IUGR, although the magnitude of the effect may decrease with further treatment. Furthermore, we suggest that it is worthwhile to treat patients who have IUGR with HGH for prolonged periods of time, if supplies exceed those necessary to treat children with growth hormone deficiency.

Growth responses to human growth hormone in patients with intrauterine growth retardation

1974 ◽  
Vol 84 (5) ◽  
pp. 635-641 ◽  
Author(s):  
Thomas P. Foley ◽  
Robert G. Thompson ◽  
Maurice Shaw ◽  
Alice Baghdassarian ◽  
S. Peter Nissley ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Growth Retardation ◽  
Intrauterine Growth Retardation ◽  
Human Growth ◽  
Growth Responses ◽  
Intrauterine Growth
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