Impaired Growth During Interferon-α Therapy in a Patient with Chronic Myelogenous Leukemia

1998 ◽  
Vol 7 (2) ◽  
pp. 105-109
Author(s):  
Toru Momoi ◽  
Chikahide Hori ◽  
Mitsuyoshi Okumura ◽  
Akira Yoshida ◽  
Rieko Tanaka ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Interferon Α

Constitutive expression of SOCS3 confers resistance to IFN-α in chronic myelogenous leukemia cells

Blood ◽  
2002 ◽  
Vol 100 (8) ◽  
pp. 2926-2931 ◽  
Author(s):  
Ikuya Sakai ◽  
Kazuto Takeuchi ◽  
Hayato Yamauchi ◽  
Hirosi Narumi ◽  
Shigeru Fujita
Keyword(s):  
Cell Line ◽  
Cell Lines ◽  
Chronic Myelogenous Leukemia ◽  
Blast Crisis ◽  
Constitutive Expression ◽  
Myelogenous Leukemia ◽  
Cytokine Signaling ◽  
Interferon Α ◽  
Socs3 Expression ◽  
Blast Cells

Because suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine-induced signaling, it has been hypothesized that aberrant SOCS expression confers resistance against cytokine therapy. This study reports on the constitutive expression of SOCS3 in most chronic myelogenous leukemia (CML) cell lines, which are resistant to treatment with interferon α (IFN-α). In contrast, the KT-1/A3 cell line, in which constitutive expression of SOCS3 is barely detectable, is sensitive to IFN-α treatment. Forced expression of SOCS3 in the KT-1/A3 cell line confers resistance to IFN-α treatment. Furthermore, most of the blast cells from patients in CML blast crisis, which are usually resistant to IFN-α therapy, showed constitutive expression of SOCS3. These findings indicate that constitutive SOCS3 expression affects the IFN-α sensitivity of CML cell lines and blast cells from patients with CML blast crisis.

Thrombotic Thrombocytopenic Purpura Complicating Chronic Myelogenous Leukemia Treated with Interferon-α

1998 ◽  
Vol 100 (4) ◽  
pp. 204-206 ◽  
Author(s):  
Rita Rachmani ◽  
Abraham Avigdor ◽  
Mona Youkla ◽  
Pia Raanani ◽  
Moshe Zilber ◽  
...  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Chronic Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Interferon Α ◽  
Thrombocytopenic Purpura

scholarly journals Acute pancreatitis associated with interferon-α therapy for chronic myelogenous leukemia

1995 ◽  
Vol 48 (3) ◽  
pp. 211-212 ◽  
Author(s):  
Manabu Sotomatsu ◽  
Masafumi Shimoda ◽  
Chitose Ogawa ◽  
Akihiro Morikawa
Keyword(s):  
Acute Pancreatitis ◽  
Chronic Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Interferon Α

Effect of interferon-α on chromosome abnormalities in treated chronic myelogenous leukemia patients

2004 ◽  
Vol 153 (2) ◽  
pp. 133-143 ◽  
Author(s):  
Hideo Tanaka ◽  
Kimio Tanaka ◽  
Nobuo Oguma ◽  
Kinro Ito ◽  
Takuo Ito ◽  
...  
Keyword(s):  
Chronic Myelogenous Leukemia ◽  
Chromosome Abnormalities ◽  
Myelogenous Leukemia ◽  
Interferon Α

Interstitial pneumonia caused by interferon-α in chronic myelogenous leukemia

1994 ◽  
Vol 47 (3) ◽  
pp. 253-253 ◽  
Author(s):  
Yuji Yufu ◽  
Sayuri Yamashita ◽  
Junji Nishimura ◽  
Hajime Nawata ◽  
Jouji Hirata
Keyword(s):  
Interstitial Pneumonia ◽  
Chronic Myelogenous Leukemia ◽  
Myelogenous Leukemia ◽  
Interferon Α
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