scholarly journals Efficacy of zinc supplementation on growth and IGF-1 in prepubertal children with idiopathic short statures and low serum zinc levels

2020 ◽  
Vol 29 (2) ◽  
pp. 63-68
Author(s):  
Kei Yoshida ◽  
Tatsuhiko Urakami ◽  
Yusuke Mine ◽  
Junichi Suzuki
Keyword(s):  
Zinc Supplementation ◽  
Serum Zinc ◽  
Prepubertal Children ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

scholarly journals The role of zinc supplementation in humoral immune response to hepatitis B vaccination in infants: a double-blind randomized placebo-controlled trial

2016 ◽  
Vol 48 (6) ◽  
pp. 374
Author(s):  
K. Suarca ◽  
Hendra S ◽  
B. N. P. Arhana ◽  
I K. G. Suandi
Keyword(s):  
Placebo Group ◽  
Hepatitis B ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Hepatitis B Vaccination ◽  
Double Blind ◽  
Baseline Serum ◽  
Zinc Supplements ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background Suboptimal zinc intake may depress thymus function,lymphoproliferation, and T cell-dependent B-cell proliferation,which can impair antibody production. Zinc supplementation canimprove immune function and reduce morbidity.Objective To assess the effect of zinc supplementation on infants'anti-HBs titer after hepatitis B vaccination.Methods A double-blind randomized control trial of 66 healthyinfants in Pustu Dauh Puri, Denpasar Barat was conducted. Subjectswere followed from birth to three months of age and were placedinto two treatment groups using block randomization. One groupreceived zinc supplements with a standard hepatitis B vaccination(zinc group, n=33) and the other group received placebosupplements with standard hepatitis B vaccination (placebo group,n=33). The serum zinc levels were measured at baseline and atthree months. The difference in levels of anti-HBs titer between thezinc and placebo groups was the primary endpoint of this study.Results The serum zinc levels were significantly higher in the zincgroup compared to the placebo group (P = 0.017), with a meandifference of 18.76 miU/ml (95% CI 3.45 to 34.07). Regardlessof baseline serum zinc levels, the mean anti-HBs titers weresignificantly higher in the zinc group compared to the placebogroup (P <0.0001; mean difference = 495.8 miU/mL; 95%CI 362.32 to 629.44). Multivariate analysis showed that zincsupplementation was the only variable that influenced anti-HBstiter levels (P < 0.0001).Conclusion Regardless of their initial zinc serum level, infantsreceiving zinc supplements along with standard hepatitis Bvaccination have significantly higher levels of anti-HBs titersthan infants receiving hepatitis B vaccination without zincsupplements.

scholarly journals Pengaruh suplementasi zink terhadap parameter hematologi atlet sepatu roda setelah latihan endurance

2018 ◽  
Vol 15 (1) ◽  
Author(s):  
Mirza Hapsari Sakti Titis Penggalih ◽  
Mustika Cahya Nirmala Dewinta ◽  
Choiri Khumaidah Fikriyah ◽  
Noni Kustia ◽  
Assyifatu Rahmah Zada ◽  
...  
Keyword(s):  
Endurance Training ◽  
Endurance Exercise ◽  
Zinc Supplementation ◽  
Cell Damage ◽  
Serum Zinc ◽  
Hemoglobin Concentration ◽  
Significant Difference ◽  
Leukocyte Counts ◽  
Zinc Levels ◽  
Serum Zinc Levels

Background: In sports such as roller skates, endurance can lead to increased inflammation and muscle cell damage, free radical formation, and zinc excretion from sweat and urine that affect the increased redistribution of zinc from blood to tissue. This mechanism causes a decrease in blood zinc levels, erythrocyte numbers and hemoglobin concentrations, increased leukocyte counts and the body’s oxidative stress parameters that have an impact on the athlete’s performance decline. Zinc supplementation may be given to maintain the athlete’s hematologic parameters during endurance exercise.Objectives: To examine the effect of zinc supplementation on serum zinc level, hemoglobin concentration, erythrocyte and leukocyte counts, and blood MDA level of skate athletes after endurance exercise.Method: This study was an experimental clinical trial using pre and post-test designs on 8 athletes incorporated in the Pre-PON DIY Wheels Team. The study was conducted in two periods, one week of endurance exercise without zinc supplementation and one week of endurance exercise with 30 mg/d of zinc supplementation. Blood sampling was performed on the seventh day of each period, before and after endurance training.Results: There was a decrease in erythrocytes and hemoglobin concentration, and a significant increase in leukocyte count after endurance training in both periods (p<0.05), but no significant difference in serum zinc levels and MDA levels after endurance training in both periods (p>0.05). Although there were no significant differences in all athlete hematologic parameters between two treatments (p>0.05), there was an improvement in serum zinc levels, hemoglobin concentrations, erythrocyte, and leukocyte counts.Conclusion: Zinc supplementation 30 mg/day for one week did not have a significant effect on the athlete’s hematology parameters after endurance exercise.

scholarly journals Zinc Intake, Zinc Serum Levels, and Intelligence in School Children in Rural Areas

2021 ◽  
Vol 9 (E) ◽  
pp. 394-397
Author(s):  
Rostika Flora ◽  
Nur Alam Fajar ◽  
Fatmalina Febri ◽  
Indah Yuliana ◽  
Yuliarti Yuliarti ◽  
...  
Keyword(s):  
Zinc Deficiency ◽  
School Children ◽  
Significant Relationship ◽  
Rural Areas ◽  
Serum Zinc ◽  
Zinc Intake ◽  
Serum Zn ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

BACKGROUND: Children in rural areas are susceptible to zinc deficiency. Zinc deficiency in children can affect cognitive function in children. Zinc plays a role in cellular function and critical brain growth processes, including cell replication, DNA and RNA synthesis, and the release of neurotransmitters. AIM: This study aimed to analyze the condition of zinc deficiency and its relationship with the level of intelligence in children in rural areas. METHODS: The study design was cross-sectional, with a sample of 44 elementary school children aged 9–12 years taken randomly. Blood was drawn to measure serum Zn-levels, and serum Zn-levels were measured using Colorimetric Assay Kit (E-BC-K137). Zinc intake data were obtained from the food recall form, which was carried out 3 × 24 h. The level of intelligence is measured by the Culture Fair Intelligence Test method. The sample characteristics data obtained through a questionnaire. Furthermore, the data were analyzed using the Chi-square test. RESULTS: About 84.2% of children with insufficient zinc intake had low serum Zn-levels. There was a significant relationship between zinc intake and serum zinc levels (p = 0.026; PR = 4.293). Children with low serum zinc levels of 96.5% have intelligence levels below average. There was a significant relationship between serum zinc levels and intelligence level as well (p = 0.001; PR = 24,500). CONCLUSION: Zinc deficiency in children is characterized by low serum Zn-levels. Low serum Zn-level is caused by low zinc intake, thus children with low serum Zn-levels are at risk of having intelligence level below average. Therefore, health education about the importance of zinc intake in children should be given to parents, so that the incidence of zinc deficiency in children can be reduced.

scholarly journals Clinical Significance of Serum Zinc Levels in Cerebral Ischemia

2010 ◽  
Vol 2010 ◽  
pp. 1-4 ◽  
Author(s):  
Archit Bhatt ◽  
Muhammad U. Farooq ◽  
Sailaja Enduri ◽  
Clement Pillainayagam ◽  
Bharath Naravetla ◽  
...  
Keyword(s):  
Functional Status ◽  
Serum Zinc ◽  
Stroke Severity ◽  
Stroke Outcome ◽  
Cellular Functions ◽  
Zinc Concentrations ◽  
Poor Functional Status ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

Background. Zinc mediates several vital physiological, enzymatic and cellular functions. The association between serum zinc and stroke outcome has not been previously evaluated.Methods. This single center retrospective study was conducted on consecutive stroke () and TIA () patients. We sought to determine whether serum zinc concentrations in patients with acute ischemic strokes were associated with stroke severity and poor functional status at discharge, respectively.Results. Overall, out of the 224 patients analyzed (mean age 67 years), 35.7% patients had low zinc levels (65 mcg/dL). Patients with stroke () were more likely to have low zinc levels (, CI , ) compared to patients with TIA (). For patients with stroke (), multivariate analysis showed that low serum zinc levels (OR 2.82, CI , ) and strokes with admission severe strokes () (OR 2.68, CI , ) were independently associated with poor functional status () at discharge from the hospital.Conclusion. Low serum zinc concentrations are associated with more severe strokes on admission and poor functional status at discharge.

Low serum zinc levels in patients undergoing coronary angiography correlate with immune activation and inflammation

2012 ◽  
Vol 26 (1) ◽  
pp. 26-30 ◽  
Author(s):  
Christian Murr ◽  
Stefan Pilz ◽  
Tanja B. Grammer ◽  
Marcus E. Kleber ◽  
Bernhard O. Böhm ◽  
...  
Keyword(s):  
Coronary Angiography ◽  
Immune Activation ◽  
Serum Zinc ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

scholarly journals Ratio of low serum zinc levels in elderly Japanese people living in the central part of Japan

2006 ◽  
Vol 61 (3) ◽  
pp. 375-381 ◽  
Author(s):  
M Kogirima ◽  
R Kurasawa ◽  
S Kubori ◽  
N Sarukura ◽  
M Nakamori ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Japanese People ◽  
Elderly Japanese ◽  
Zinc Levels ◽  
Serum Zinc Levels ◽  
Low Serum

scholarly journals Does zinc supplementation improve dietary intake, symptoms of eating problems, and serum zinc levels in hemodialysis patients?

2010 ◽  
Vol 39 (12) ◽  
pp. 530-533 ◽  
Author(s):  
Jamal Ghaemmaghami ◽  
Reza Mahdavi ◽  
Elnaz Faramarzi ◽  
Noshin Mohammadpour ◽  
Hassan Argani
Keyword(s):  
Dietary Intake ◽  
Zinc Supplementation ◽  
Serum Zinc ◽  
Hemodialysis Patients ◽  
Eating Problems ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Zinc Supplementation as Adjunctive Therapy in Adults with Tuberculosis in Calabar, Nigeria: A Randomized Controlled Trial

2019 ◽  
pp. 1-13
Author(s):  
Regina I. Ejemot-Nwadiaro ◽  
Edisua H. Itam ◽  
Emmanuel N. Ezedinachi
Keyword(s):  
Zinc Supplementation ◽  
Intervention Group ◽  
Serum Zinc ◽  
Drug Regimen ◽  
Haematological Parameters ◽  
Control Group ◽  
Tb Treatment ◽  
Zinc Levels ◽  
The Impact ◽  
Serum Zinc Levels

Introduction: Tuberculosis (TB) still remains a leading killer from a single infectious agent worldwide, especially in Asia and Africa. Achieving the Sustainable Development Goal (SDG) 3 will be contingent on addressing ways of reducing the impact of TB to the health, socio-economic and health system of populations most at risk. Micronutrients supplementation is increasingly being recognized as having great potentials to that effect. Objective: This study thus assessed the potential benefits or otherwise of zinc supplementation on tuberculosis treatment outcomes in Calabar, Nigeria. Methods: Eligible patients (81) out of the 182 assessed were randomized to receive anti-TB drug regimen plus oral administration of individual zinc, 25 mg daily for 60 days (intervention group), while the control group received anti-tuberculosis drug regimen only for 60 days. Both qualitative and quantitative data were collected. Clinical examination, Karnofsky performance scale index, direct sputum examination, anthropometric measurements and blood collection for haematological and zinc assessment were carried out before and 2 months after anti-TB treatment began.  Difference in treatment effects between and within groups for continuous variables was tested using t-test. Mantel-Haenszel summary estimate of the relative risk (RR) was used to test the clinical effectiveness of the intervention. The Pearson test was applied to determine the correlation between variables. Main Results: The mean serum zinc levels at 2 months of TB treatment were significantly higher in the intervention group (14.4 ± 0.37µmol/L) in comparison with the control (12.9 ± 0.37 µmol/L); (p = 0.004). A significant difference (p = 0.010) in the serum concentrations of zinc was observed between the two groups when adjustments were made for TB-HIV co-infection. Risk reduction of about 41% for acid fast bacilli (AFB) positivity (RR: 0.59; 95% CI 0.23 to 1.46) was observed after 2 months of anti-TB treatment in favour of the intervention group. Similarly, intervention group had significantly (p = 0.005) lower proportion of patients with serum zinc levels < 10.7 µmol/L (intervention: 5; Control 10) and (p = 0.030) BMI < 18.5 kg /m2 below the lower ranges ((intervention: 9; Control 16). There was a significant improvement in the haematological parameters as evidenced by significant higher proportion of patients in the intervention group than the control group with values above the lower ranges for these parameters with risk reductions in favour of the intervention group for lower ranges as 34%, 12%, 73% and 58% respectively for haemoglobin, albumin, serum total protein and globulins. Conclusion: Irrespective of HIV status in individuals with tuberculosis, zinc micronutrient supplementation significantly increases clinical outcomes, haematological parameters, improves nutritional status as proxied by anthropometric indices and leads to faster sputum smear conversion. The study adds to the growing body of evidence in support of the beneficial role of zinc in TB control.

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