scholarly journals Treatment of Hypothyroidism due to Iodine Deficiency Using Daily Powdered Kelp in Patients Receiving Long-term Total Enteral Nutrition

2011 ◽  
Vol 20 (3) ◽  
pp. 51-55 ◽  
Author(s):  
Takako Takeuchi ◽  
Hotaka Kamasaki ◽  
Tomoyuki Hotsubo ◽  
Hiroyuki Tsutsumi
2011 ◽  
Vol 300 (1) ◽  
pp. G109-G119 ◽  
Author(s):  
Martin J. J. Ronis ◽  
Leah Hennings ◽  
Ben Stewart ◽  
Alexei G. Basnakian ◽  
Eugene O. Apostolov ◽  
...  

Male Sprague-Dawley rats were chronically fed a high-unsaturated-fat diet for 130 days by using total enteral nutrition (TEN), or the same diet in which ethanol (EtOH) isocalorically replaced carbohydrate calories. Additional groups were supplemented with the antioxidant N-acetylcysteine (NAC) at 1.7 g·kg−1·day−1. Relative to an ad libitum chow-fed group, the high-fat-fed controls had three- to fourfold greater expression of fatty acid transporter CD36 mRNA and developed mild steatosis but little other hepatic pathology. NAC treatment resulted in increased somatic growth relative to controls (4.0 ± 0.1 vs. 3.1 ± 0.1 g/day) and increased hepatic steatosis score (3.5 ± 0.6 vs. 2.7 ± 1.2), associated with suppression of the triglyceride hydrolyzing protein adiponutrin, but produced no elevation in serum alanine aminotransferase (ALT). Chronic EtOH treatment increased expression of fatty acid transport protein FATP-2 mRNA twofold, resulting in marked hepatic steatosis, oxidative stress, and a twofold elevation in serum ALT. However, no changes in tumor necrosis factor-α or transforming growth factor-β expression were observed. Fibrosis, as measured by Masson's trichrome and picrosirius red staining, and a twofold increase in expression of type I and type III collagen mRNA, was only observed after EtOH treatment. Long-term EtOH treatment increased hepatocyte proliferation but did not modify the hepatic mRNAs for hedgehog pathway ligands or target genes or genes regulating epithelial-to-mesenchymal transition. Although the effects of NAC on EtOH-induced fibrosis could not be fully evaluated, NAC had additive effects on hepatocyte proliferation and prevented EtOH-induced oxidative stress and necrosis, despite a failure to reverse hepatic steatosis.


2015 ◽  
Vol 16 (2) ◽  
pp. 90-94 ◽  
Author(s):  
Yusaku Kajihara ◽  
Ichiro Mizuki

1986 ◽  
Vol 34 (5) ◽  
pp. 385-388 ◽  
Author(s):  
Sunil Jhangiani ◽  
Laura Prince ◽  
Rosemarie Holmes ◽  
Nanak Agarwal

The Lancet ◽  
1993 ◽  
Vol 341 (8849) ◽  
pp. 869-872 ◽  
Author(s):  
M.A. Hull ◽  
J. Rawlings ◽  
J. Field ◽  
S.P. Allison ◽  
F.E. Murray ◽  
...  

2002 ◽  
Vol 301 (3) ◽  
pp. 1132-1138 ◽  
Author(s):  
Elizabeth C. Brown ◽  
Daniel S. Perrien ◽  
Terry W. Fletcher ◽  
David J. Irby ◽  
James Aronson ◽  
...  

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