Upper facial rejuvenation: the role of surgical and non-surgical interventions

2016 ◽  
Vol 5 (2) ◽  
pp. 60-68 ◽  
Author(s):  
Connie Brennan
Keyword(s):  
Facial Rejuvenation ◽  
Surgical Interventions

scholarly journals The Potential Role of Bacteriophages in the Treatment of Recalcitrant Chronic Rhinosinusitis

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 675
Author(s):  
Saartje Uyttebroek ◽  
Jolien Onsea ◽  
Willem-Jan Metsemakers ◽  
Lieven Dupont ◽  
David Devolder ◽  
...  
Keyword(s):  
Chronic Rhinosinusitis ◽  
Biofilm Formation ◽  
Potential Role ◽  
Phage Therapy ◽  
Well Being ◽  
Treatment Alternative ◽  
Surgical Interventions ◽  
Social And Emotional ◽  
Promising Treatment

Chronic rhinosinusitis is a common condition affecting 5–12% of the general population worldwide. In a limited number of cases, the disease is recalcitrant to medical and surgical interventions, causing a major impact on physical, social and emotional well-being and increasing pressure on healthcare systems. Biofilm formation and dysbiosis caused by Staphylococcus aureus and Pseudomonas aeruginosa play a role in the pathogenesis of recalcitrant chronic rhinosinusitis. In these cases, a promising treatment alternative is the application of bacteriophages, which are viruses that infect and lyse bacteria. In this review, we appraise the evidence for the use of bacteriophages in the treatment of recalcitrant chronic rhinosinusitis. Additionally, (dis)advantages of bacteriophages and considerations for implementation of phage therapy in otorhinolaryngology practice will be discussed.

The role of the registered nurse first assistant within the perioperative setting

2021 ◽  
Vol 30 (3) ◽  
pp. 148-153
Author(s):  
Roland Pika ◽  
Brid O'Brien ◽  
Jill Murphy ◽  
Kathleen Markey ◽  
Claire O'Donnell
Keyword(s):  
Registered Nurse ◽  
Healthcare Sector ◽  
Review Of The Literature ◽  
Surgical Interventions ◽  
Medical Practitioners ◽  
Nursing Role ◽  
Perioperative Nursing ◽  
Recent Emergence ◽  
Provision Of Care

Perioperative setting registered nurse first assistants (RNFAs) are described as non-medical practitioners who perform surgical interventions during surgery. They provide medical care to perioperative patients under the supervision of a consultant surgeon. First assistants in surgery can be an expanded perioperative nursing role. A review of the literature illuminates the need for continuous learning in developing skills in becoming competent RNFA practitioners and how they utilise acquired skills to assist, mentor and teach their colleagues within the perioperative setting. The RNFA is an advanced and expanded practice role. RNFAs contribute significantly to the provision of care within all phases of perioperative care (preoperative, intraoperative, postoperative). There is little literature on the role of the RNFA due to its relatively recent emergence in the healthcare sector and the small number of countries where it is implemented.

Role of Percutaneous Transhepatic Biliary Drainage in Patients With Complications After Gastrectomy

2016 ◽  
Vol 101 (1-2) ◽  
pp. 78-83 ◽  
Author(s):  
Ki-Han Kim ◽  
Ho-Byoung Lee ◽  
Sung-Heun Kim ◽  
Min-Chan Kim ◽  
Ghap-Joong Jung
Keyword(s):  
Biliary Drainage ◽  
Percutaneous Transhepatic Biliary Drainage ◽  
Duodenal Stump ◽  
Surgical Interventions ◽  
Afferent Loop Syndrome ◽  
Soft Diet ◽  
Bile Drainage ◽  
Duodenal Stump Leakage ◽  
Transhepatic Biliary Drainage

The aim of this study was to elucidate the role of percutaneous transhepatic biliary drainage (PTBD) in patients with duodenal stump leakage (DSL) and afference loop syndrome (ALS) postgastrectomy for malignancy or benign ulcer perforation. Percutaneous transhepatic biliary drainage (PTBD) is an interventional radiologic procedure used to promote bile drainage. Duodenal stump leakage (DSL) and afferent loop syndrome (ALS) can be serious complications after gastrectomy. From January 2002 through December 2014, we retrospectively reviewed 19 patients who underwent PTBD secondary to DSL and ALS postgastrectomy. In this study, a PTBD tube was placed in the proximal duodenum near the stump or distal duodenum in order to decompress and drain bile and pancreatic fluids. Nine patients with DSL and 10 patients with ALS underwent PTBD. The mean hospital stay was 34.3 days (range, 12 to 71) in DSL group and 16.4 days (range, 6 to 48) in ALS group after PTBD. A liquid or soft diet was started within 2.6 days (range, 1 to 7) in the ALS group and within 3.4 days (range, 0 to 15) in the DSL group after PTBD. One patient with DSL had PTBD changed, and 2 patients with ALS underwent additional surgical interventions after PTBD. The PTBD procedure, during which the tube was inserted into the duodenum, was well-suited for decompression of the duodenum as well as for drainage of bile and pancreatic fluids. This procedure can be an alternative treatment for cases of DSL and ALS postgastrectomy.

scholarly journals Functional ismico-cervical insufficiency and its therapy with dufastone in outpatient settings

1999 ◽  
Vol 48 (2) ◽  
pp. 82-83
Author(s):  
V. V. Abramchenko
Keyword(s):  
Differential Diagnosis ◽  
Surgical Treatment ◽  
Termination Of Pregnancy ◽  
Cervical Insufficiency ◽  
Surgical Interventions ◽  
Outpatient Settings ◽  
In Pregnancy

The role of ischemic-duodenal insufficiency (IDI) in spontaneous termination of pregnancy has not been fully elucidated. The development of various modifications of the surgical treatment of IDI is of great importance, which has led to a very wide use of surgical interventions on the cervix, including "prophylactic" interventions. The application of a circular suture to the cervix is appropriate only in cases where there is an organic variant of this pathology. Differential diagnosis of organic and functional IDI in pregnancy is difficult.

scholarly journals The role of surgery in the management of women with gestational trophoblastic disease

2017 ◽  
Vol 44 (1) ◽  
pp. 94-101 ◽  
Author(s):  
LANA DE LOURDES AGUIAR LIMA ◽  
LÍLIAN PADRON ◽  
RAPHAEL CÂMARA ◽  
SUE YAZAKI SUN ◽  
JORGE REZENDE FILHO ◽  
...  
Keyword(s):  
Placental Tissue ◽  
High Sensitivity ◽  
Gestational Trophoblastic Disease ◽  
Human Chorionic Gonadotrophin ◽  
Gestational Trophoblastic Neoplasia ◽  
Chemotherapy Treatment ◽  
Invasion And Metastasis ◽  
Surgical Interventions ◽  
Trophoblastic Disease

ABSTRACT The Gestational Trophoblastic Disease includes an interrelated group of diseases originating from placental tissue, with distinct behaviors concerning local invasion and metastasis. The high sensitivity of the serial dosages of human chorionic gonadotrophin, combined with advances in chemotherapy treatment, have made gestational trophoblastic neoplasia curable, most often through chemotherapy. However, surgery remains of major importance in the management of patients with gestational trophoblastic disease, improving their prognosis. Surgery is necessary in the control of the disease's complications, such as hemorrhage, and in cases of resistant/relapsed neoplasia. This review discusses the indications and the role of surgical interventions in the management of women with molar pregnancy and gestational trophoblastic neoplasia.

scholarly journals Acute Hepatic Dysfunction Related to Chronic Acetaminophen Administration

2021 ◽  
Vol 26 (5) ◽  
pp. 497-501
Author(s):  
Ellen Rootring ◽  
Cheryl L. Sargel ◽  
Joseph D. Tobias
Keyword(s):  
Potential Role ◽  
Hepatic Dysfunction ◽  
Esophageal Fistula ◽  
Prevention Strategies ◽  
Surgical Interventions ◽  
Button Battery ◽  
Acute Ingestion ◽  
Chronic Ingestion

Toxicity related to acetaminophen is most encountered with the acute ingestion of large doses. However, toxicity may also result from chronic ingestion, even when recommended doses are administered over a prolonged period of time. We present the case of a 20-month-old female toddler who received therapeutic recommended doses of acetaminophen (oral or intravenous) following multiple surgical interventions for treatment of a tracheo-esophageal fistula following ingestion of a button battery. The potential role of chronic acetaminophen administration in the etiology of hepatoxicity is discussed and prevention strategies are presented.

scholarly journals Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Amir R. Afshari ◽  
Hamid Mollazadeh ◽  
Amirhossein Sahebkar
Keyword(s):  
Antimicrobial Activity ◽  
Glioblastoma Multiforme ◽  
Cancer Therapy ◽  
Cell Invasion ◽  
Treatment Approach ◽  
Tumor Cell Invasion ◽  
Surgical Interventions ◽  
Anticancer Effects ◽  
New Treatment

One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM.

scholarly journals Role of Ancillary Procedures in Facial Rejuvenation

2019 ◽  
Vol 7 (6) ◽  
pp. e2075
Author(s):  
Rod. J. Rohrich ◽  
Raja Mohan
Keyword(s):  
Facial Rejuvenation

scholarly journals Nonsteroidal Anti-Inflammatory Drugs: A Potential Pharmacological Treatment for Intracranial Aneurysm

2019 ◽  
Vol 9 (1) ◽  
pp. 31-45 ◽  
Author(s):  
Courtney L. Fisher ◽  
Stacie L. Demel
Keyword(s):  
Nuclear Factor Κb ◽  
High Morbidity ◽  
Surgical Interventions ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Factor Α ◽  
Wall Sheer Stress ◽  
Cox 2 Inhibitors

Background: Saccular intracranial aneurysms (IAs) are outpouchings of the vessel wall of intracranial arteries. Rupture of IAs results in subarachnoid hemorrhage which is associated with high morbidity and mortality. Surgical interventions, such as clipping and coiling, have associated risks. Currently, there are no proven pharmacological treatments to prevent the growth or rupture of IAs. Infiltration of proinflammatory cytokines in response to increased wall sheer stress is a hallmark of IA. Nonsteroidal anti-inflammatory drugs (NSAIDs) are being investigated as potential therapeutic agents for reduction in growth and/or prevention of IA through inhibition of inflammatory pathways. Summary: This review will discuss the role of NSAIDs in attenuating the inflammation that drives IA progression and rupture. There are two main subtypes of NSAIDs, nonselective COX and selective COX-2 inhibitors, both of which have merit in treating IA. Evidence will be presented which shows that NSAIDs inhibit several key inflammatory mediators involved in IA progression including nuclear factor-κB, tumor necrosis factor-α, and matrix metalloproteinases. In addition, the role of NSAIDs in limiting inflammatory cell adhesion to endothelial cells and attenuating endothelial cell senescence will be discussed. Key Messages: There is an abundance of basic science and preclinical data that support NSAIDs as a promising treatment for IA. Additionally, a combination treatment strategy of low-dose aspirin given concomitantly with a selective COX-2 inhibitor may result in a reduced side effect profile compared to aspirin or selective COX-2 inhibitor use alone. Several large clinical trials are currently planned to further investigate the efficacy of NSAIDs as an effective nonsurgical treatment for IAs.

Evolving Therapeutic Strategies in Mucosal Melanoma Have Not Improved Survival over Five Decades

2016 ◽  
Vol 82 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Daniel D. Kirchoff ◽  
Gary B. Deutsch ◽  
Leland J. Foshag ◽  
Ji Hey Lee ◽  
Myung-Shin Sim ◽  
...  
Keyword(s):  
Overall Survival ◽  
Adjuvant Therapy ◽  
Mucosal Melanoma ◽  
Surgical Interventions ◽  
Entire Cohort ◽  
The Past ◽  
Survival Difference ◽  
Disease Site ◽  
The Ideal

Mucosal melanoma represents a distinct minority of disease sites and portends a worse outcome. The ideal treatment and role of adjuvant therapy remains unknown at this time. We hypothesized that a combination of neoadjuvant and adjuvant therapies would improve survival in these aggressive melanomas. Our large, prospectively maintained melanoma database was queried for all patients diagnosed with mucosal melanoma. Over the past five decades, 227 patients were treated for mucosal melanoma. There were 82 patients with anorectal, 75 with sinonasal, and 70 with urogenital melanoma. Five-year overall survival and melanoma-specific survival for the entire cohort were 32.8 and 37.5 per cent, respectively, with median overall survival of 38.7 months. One hundred forty-two patients (63.8%) underwent adjuvant therapy and 15 were treated neo-adjuvantly (6.6%). There was no survival difference by therapy type or timing, disease site, or decade of diagnosis. There was improved survival in patients undergoing multiple surgeries (Hazard Ratio [HR] 0.55, P = 0.0005). Patients receiving neoadjuvant therapy had significantly worse survival outcomes (HR 2.49, P = 0.013). Over the past five decades, improvements have not been seen in outcomes for mucosal melanoma. Although multiple surgical interventions portend a better outcome in patients with mucosal melanoma, adjuvant treatment decisions must be individualized.

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