Paving the way for a new generation of pioneers in heart failure nursing: the BSH Lynda Blue Award

2020 ◽  
Vol 15 (9) ◽  
pp. 1-2
Author(s):  
Carys Barton ◽  
Annie MacCallum
Keyword(s):  
Heart Failure ◽  
New Generation ◽  
The Way

scholarly journals Recent Advances in Single-Cell Profiling and Multispecific Therapeutics: Paving the Way for a New Era of Precision Medicine Targeting Cardiac Fibroblasts

2021 ◽  
Vol 23 (7) ◽  
Author(s):  
Sally Yu Shi ◽  
Xin Luo ◽  
Tracy M. Yamawaki ◽  
Chi-Ming Li ◽  
Brandon Ason ◽  
...  
Keyword(s):  
Heart Failure ◽  
Precision Medicine ◽  
Single Cell ◽  
Cardiac Fibroblasts ◽  
Rapid Development ◽  
Cardiac Fibroblast ◽  
New Era ◽  
Fibroblast Activation ◽  
Cell Gene Expression ◽  
The Way

Abstract Purpose of Review Cardiac fibroblast activation contributes to fibrosis, maladaptive remodeling and heart failure progression. This review summarizes the latest findings on cardiac fibroblast activation dynamics derived from single-cell transcriptomic analyses and discusses how this information may aid the development of new multispecific medicines. Recent Findings Advances in single-cell gene expression technologies have led to the discovery of distinct fibroblast subsets, some of which are more prevalent in diseased tissue and exhibit temporal changes in response to injury. In parallel to the rapid development of single-cell platforms, the advent of multispecific therapeutics is beginning to transform the biopharmaceutical landscape, paving the way for the selective targeting of diseased fibroblast subpopulations. Summary Insights gained from single-cell technologies reveal critical cardiac fibroblast subsets that play a pathogenic role in the progression of heart failure. Combined with the development of multispecific therapeutic agents that have enabled access to previously “undruggable” targets, we are entering a new era of precision medicine.

RHEUMATIC PNEUMONITIS IN CHILDHOOD

PEDIATRICS ◽  
1948 ◽  
Vol 2 (6) ◽  
pp. 688-693
Author(s):  
HAROLD B. LEVY ◽  
JOHN D. COFFEY ◽  
CHARLES E. ANDERSON
Keyword(s):  
Heart Failure ◽  
Rheumatic Fever ◽  
Cause Of Death ◽  
Respiratory System ◽  
Bacterial Pneumonia ◽  
Pulmonary Involvement ◽  
Sufficient Data ◽  
Precipitating Factor ◽  
The Way

Sufficient data are presented to indicate the pathologic entity of rheumatic pneumonitis and its position of importance as an outstanding cause of death in rheumatic fever, either primarily or secondarily. In each of the five autopsied cases, there was sufficiently severe and widespread pulmonary involvement to suggest that the pneumonitis led the way to the fatal termination, either by impairment of the respiratory system alone, or by further adding to the load of an already dangerously impaired cardiac mechanism. If, as Stewart has said, the danger of bacterial pneumonia is such an acute one as a precipitating factor in heart failure, how much more perilous is the existence of a severe involvement which appears to be part and parcel of the rheumatic picture as a whole.

Women in science: the need for a global cultural change

2019 ◽  
Vol 15 (S367) ◽  
pp. 281-285
Author(s):  
Karen Hallberg
Keyword(s):  
Cultural Change ◽  
Current Situation ◽  
Women In Science ◽  
Cultural Aspect ◽  
Science Technology ◽  
Participation Of Women ◽  
And Mathematics ◽  
New Generation ◽  
Cultural Maturity ◽  
The Way

AbstractThis paper summarizes the talk given at this conference in which the cultural aspect of the low participation of women in science, mainly in STEM (Science, Technology, Engineering and Mathematics) areas, is emphazised. A few personal recollections will be presented and some some striking numbers to illustrate the current situation will be given. In addition, some thought provoking ideas on what is known as “neurosexism” are explicited and a tribute is made to three women that overcame the challenges posed to them in different times in history (including current times) and helped paved the way to the new generation. However, there is still a long way to go. The inclusion of women and of other relegated sectors of society in scientific and technological activities is an important pending issue which will be achieved when our society as a whole reaches the necessary cultural maturity.

"النار العاتية التي ذاقت من طعم وهج اللهيب:"

Al-Abhath ◽  
2020 ◽  
Vol 68 (1) ◽  
pp. 106-181
Author(s):  
هاني رشوان
Keyword(s):  
Close Relation ◽  
Literary Texts ◽  
Egyptian Arabic ◽  
Ancient Egyptian ◽  
Similar Images ◽  
Senwosret Iii ◽  
New Generation ◽  
Literary Devices ◽  
Classical Arabic ◽  
The Way

This article offers the first Arabic translation of a praise hymn dedicated to Ramsess II (d. 1213 B.C.E.), with philological and poetic commentaries. The text was carved on the facade of Abū Simbel temple twice because of its exceptional literary nature, as this study demonstrates. I discuss why Euro- American scholars were unable to separate the literary dimensions of the praise hymns from its political framework, and also tackle the pictorial nature of ancient Egyptian writing, providing the Arabic reader with the necessary instruments for understanding the several visual features that were creatively deployed by the writer to enhance the reading process of this particular praise hymn. I then trace the early foundations of premodern Arabic khiṭāba and its close relation to constructing oral/aural arguments in comparison with balāgha that deals with the literary devices of the Qur’ānic text. This study breaks new ground in the discipline of comparative literature by establishing a collation between the two praise hymns of Ramsess II (d. 1213 B.C.E.) and Senwosret III (d. 1839 B.C.E.). This collation makes it possible to rediscover the way each eulogist built unique or similar images to describe the praised king. The article discusses several problematic questions of loanwords to pave the way for further research on ancient Egyptian words that were incorporated inside the classical Arabic dictionary, and the analysis ends with an ancient Egyptian-Arabic lexicon of the hymn under study. It is hoped that this may encourage the new generation of Egyptian Egyptologists to generate a comprehensive dictionary of the ancient Egyptian language based on direct engagement with ancient Egyptian literary texts.

scholarly journals Gender differences in heart failure: paving the way towards personalized medicine?

2010 ◽  
Vol 31 (10) ◽  
pp. 1165-1167 ◽  
Author(s):  
S. H. Schirmer ◽  
M. Hohl ◽  
M. Bohm
Keyword(s):  
Heart Failure ◽  
Gender Differences ◽  
Personalized Medicine ◽  
The Way

scholarly journals Paving the way for destination therapy of end-stage biventricular heart failure: the ReinHeart total artificial heart concept

2014 ◽  
Vol 46 (6) ◽  
pp. 935-936 ◽  
Author(s):  
R. Koerfer ◽  
S. Spiliopoulos ◽  
T. Finocchiaro ◽  
D. Guersoy ◽  
G. Tenderich ◽  
...  
Keyword(s):  
Heart Failure ◽  
Artificial Heart ◽  
Total Artificial Heart ◽  
Destination Therapy ◽  
End Stage ◽  
The Way
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