scholarly journals Effects of N-acetylcysteine supplementation on cellular damage and oxidative stress indicators in volleyball athletes

2018 ◽  
Vol 14 (5) ◽  
pp. 802-809 ◽  
Author(s):  
Alan de Jesus Pires de Moraes ◽  
Leonardo Vidal Andreato ◽  
Braulio Henrique Magnani Branco ◽  
Edson Luiz da Silva ◽  
Márcia Aparecida Gonçalves ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cellular Damage ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

scholarly journals XBP1-Mediated BiP/GRP78 Upregulation Copes with Oxidative Stress in Mosquito Cells during Dengue 2 Virus Infection

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Tien-Huang Chen ◽  
Yi-Hsuan Chiang ◽  
Jiun-Nan Hou ◽  
Chih-Chieh Cheng ◽  
Eny Sofiyatun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Target Gene ◽  
Cytosolic Calcium ◽  
Cellular Damage ◽  
Factor X ◽  
Stress Indicators ◽  
Mosquito Cells ◽  
Tropical Areas ◽  
Oxidative Stress Indicators ◽  
Denv2 Infection

Dengue viruses (DENVs) cause dengue fever which is an important mosquito-borne disease in tropical areas. Generally, DENV does not cause cellular damage in mosquito cells. However, alterations in cytosolic calcium ions ([Ca2+]cyt) and the mitochondrial membrane potential (MMP), as well as accumulated reactive oxygen species (ROS), including superoxide anions (O2∙-) and hydrogen peroxide (H2O2), can be detected in C6/36 cells with DENV2 infection. Evident upregulation of BiP/GRP78 also appeared at 24 h postinfection in DENV2-infected C6/36 cells. As expression of BiP/GRP78 mRNA was reduced when the transcription factor X-box-binding protein-1 (XBP1) was knocked down in C6/36 cells, it demonstrated that BiP/GRP78 is the target gene regulated by the XBP1 signal pathway. We further demonstrated that the expression and splicing activity of XBP1 were upregulated in parallel with DENV2 infection in C6/36 cells. In C6/36 cells with BiP/GRP78 overexpression, oxidative stress indicators including [Ca2+]cyt, MMP,O2∙-, and H2O2were all pushed back to normal. Taken together, DENV2 activates XBP1 at earlier stage of infection, followed by upregulating BiP/GRP78 in mosquito cells. This regulatory pathway contributes a cascade in relation to oxidative stress alleviation. The finding provides insights into elucidating how mosquitoes can healthily serve as a vector of arboviruses in nature.

Theranostic TEMPO-functionalized Ru(ii) complexes as photosensitizers and oxidative stress indicators

2017 ◽  
Vol 46 (2) ◽  
pp. 445-454 ◽  
Author(s):  
Jing Yang ◽  
Qian Cao ◽  
Wei-Liang Hu ◽  
Rui-Rong Ye ◽  
Liang He ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Photodynamic Therapy ◽  
Polypyridyl Complexes ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

New TEMPO-functionalized Ru(ii) polypyridyl complexes displayed greatly improved PDT efficacy, capable of simultaneously monitoring cellular oxidative stress during photodynamic therapy.

scholarly journals NEUROPROTECTIVE EFFECT OF WATERMELON (CITRULLUS LANATUS) PULP JUICE ON SCOPOLAMINE-INDUCED MEMORY DEFICITS IN SWISS ALBINO MICE: THE ROLE OF ACETYLCHOLINESTERASE AND OXIDATIVE STRESS

2021 ◽  
Vol 12 (3) ◽  
pp. 52-56
Author(s):  
Divya N ◽  
Amudha P ◽  
Viveka K Priya
Keyword(s):  
Oxidative Stress ◽  
Ache Activity ◽  
Citrullus Lanatus ◽  
Neuroprotective Effect ◽  
Memory Deficits ◽  
Memory Deficit ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

The effect of Watermelon (Citrullus lanatus) Pulp Juice (WPJ) on scopolamine (SCOP) induced memory deficits is due to the involvement of oxidative stress and AChE activity. The juice was obtained by crushing the pulp in blender and three different concentrations of 100%, 50% and 25% was administration to prevent memory deficit by evaluating changes of AChE activity and oxidative stress indicators (SOD, CAT, LPO and GPx) induced by scopolamine. These results provide evidence that WPJ is an alternative to protect SCOP induced memory deficits in mice by involvement of oxidative stress and AChE activity.

scholarly journals Comparative effects of target-controlled infusion of anesthetic sufentanil and remifentanil on inflammatory factors and oxidative stress indicators in patients of colorectal cancer

2019 ◽  
Vol 17 ◽  
pp. 205873921986328
Author(s):  
Xiaohui Chen ◽  
Zhongyuan Hu ◽  
Wenjun Yan ◽  
Yabing Ma ◽  
Man He ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Colorectal Cancer ◽  
Adverse Reactions ◽  
Inflammatory Factors ◽  
Stress Indicators ◽  
Target Controlled Infusion ◽  
Extubation Time ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress ◽  
Remifentanil Group

This study was designed to compare the recovery of target-controlled infusion of sufentanil and remifentanil in patients of colorectal cancer. In total, 104 patients were randomly divided into sufentanil and remifentanil groups. One group was given target-controlled infusion of sufentanil, while the other group received remifentanil. Inflammatory factors and oxidative stress indicators were measured at 10 min before induction of anesthesia (T1), 1 h (T2), 24 h (T3), and 72 h (T4) after surgery. Adverse reactions were also compared. The extubation and recovery time of sufentanil group were longer than remifentanil group. The levels of CRP, IL-8, and IL-4 in sufentanil group and remifentanil group increased continuously. CRP contents at T3, T4, and IL-8 and IL-4 contents at T2, T3, and T4 of remifentanil group were lower ( P < 0.05). The incidence of adverse reactions in sufentanil group was 15.4%, which was significantly ( P < 0.05) lower than remifentanil group (28.8%). The recovery and extubation time of sufentanil were longer than remifentanil, while the remifentanil can effectively reduce the levels of inflammatory factors and oxidative stress.

scholarly journals Spirulina Maxima Decreases Endothelial Damage and Oxidative Stress Indicators in Patients with Systemic Arterial Hypertension: Results from Exploratory Controlled Clinical Trial

2018 ◽  
Author(s):  
Jesús Martínez-Sámano ◽  
Adriana Torres-Montes de Oca ◽  
Oscar Ivan Luqueño-Bocardo ◽  
Patricia V. Torres-Durán ◽  
Marco Antonio Juárez-Oropeza
Keyword(s):  
Oxidative Stress ◽  
Glutathione Peroxidase ◽  
Arterial Hypertension ◽  
Endothelial Damage ◽  
Oxidized Glutathione ◽  
Spirulina Maxima ◽  
Stress Indicators ◽  
Systemic Arterial Hypertension ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

1) Background: Spirulina (Arthrospira) maxima has shown beneficial effects such anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. 2) Methods: a prospective, randomized, parallel pilot study of 4.5 g administration of Spirulina maxima or placebo for 12 weeks in 16 patients with systemic arterial hypertension undergoing treatment with ACE inhibitors was performed to assess the effects on endothelial damage and oxidative stress indicators. The blood levels of sICAM-1, sVCAM-1, endothelin-1, and sE-selectin were quantified; the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and concentrations of reduced glutathione, oxidized glutathione, and thiobarbituric acid reactive susbtances, were also quantified before and after the treatment period. 3) Results: There were statistically significant (p &lt; 0.05) decreases in systolic blood pressure, sVCAM-1, sE-selectin and endothelin-1 levels, and increases in glutathione peroxidase activity and oxidized glutathione levels. 4) Conclusion: The effects found in the present study agree with antihypertensive and antioxidant effects previously reported for Spirulina maxima. However, this is the first report about the effects on indicators of endothelial damage. More research in this field is necessary to gain an insight into the effects of Spirulina on these indicators.&nbsp; &nbsp;

Sign in / Sign up

Export Citation Format

Share Document