scholarly journals Treadmill exercise ameliorates motor dysfunction through inhibition of Purkinje cell loss in cerebellum of valproic acid-induced autistic rats

2016 ◽  
Vol 12 (4) ◽  
pp. 293-298 ◽  
Author(s):  
Han-Sam Cho ◽  
Tae-Woon Kim ◽  
Eun-Sang Ji ◽  
Hye-Sang Park ◽  
Mal-Soon Shin ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Purkinje Cell ◽  
Treadmill Exercise ◽  
Cell Loss ◽  
Motor Dysfunction ◽  
Purkinje Cell Loss

scholarly journals Autistic-Like Behaviors, Oxidative Stress Status, and Histopathological Changes in Cerebellum of Valproic Acid Rat Model of Autism Are Improved by the Combined Extract of Purple Rice and Silkworm Pupae

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Nartnutda Morakotsriwan ◽  
Jintanaporn Wattanathorn ◽  
Woranan Kirisattayakul ◽  
Kowit Chaisiwamongkol
Keyword(s):  
Oxidative Stress ◽  
Valproic Acid ◽  
Purkinje Cell ◽  
Rat Model ◽  
Cell Loss ◽  
Hot Plate ◽  
Hot Plate Test ◽  
Silkworm Pupae ◽  
Oxidative Stress Status ◽  
Purkinje Cell Loss

Due to the crucial role of oxidative stress on the pathophysiology of autism and the concept of synergistic effect, the benefit of the combined extract of purple rice and silkworm pupae (AP1) for autism disorder was the focus. Therefore, we aimed to determine the effect of AP1 on autistic-like behaviors, oxidative stress status, and histopathological change of cerebellum in valproic acid (VPA) rat model of autism. VPA was injected on postnatal day (PND) 14 and the animals were orally given AP1 at doses of 50, 100, and 200 mg·kg−1BW between PND 14 and PND 40. The autism-like behaviors were analyzed via hot-plate, rotarod, elevated plus-maze, learning, memory, and social behavior tests. Oxidative stress and the histological change in the cerebellum were assessed at the end of study. AP1 treated rats improved behaviors in all tests except that in hot-plate test. The improvement of oxidative stress and Purkinje cell loss was also observed in the cerebellum of VPA-treated rats. Our data suggest that AP1 partially reduced autism-like behaviors by improving oxidative stress and Purkinje cell loss. Further research is required to identify the active ingredients in AP1 and gender difference effect.

Effect of treadmill exercise on Purkinje cell loss and astrocytic reaction in the cerebellum after traumatic brain injury

2010 ◽  
Vol 481 (3) ◽  
pp. 178-182 ◽  
Author(s):  
Tae-Beom Seo ◽  
Bo-Kyun Kim ◽  
Il-Gyu Ko ◽  
Dong-Hyun Kim ◽  
Mal-Soon Shin ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Purkinje Cell ◽  
Treadmill Exercise ◽  
Cell Loss ◽  
Purkinje Cell Loss

scholarly journals Treadmill Exercise Improves Motor Function by Suppressing Purkinje Cell Loss in Parkinson Disease Rats

2018 ◽  
Vol 22 (Suppl 3) ◽  
pp. S147-155 ◽  
Author(s):  
Jae-Min Lee ◽  
Tae-Woon Kim ◽  
Sang-Seo Park ◽  
Jin-Hee Han ◽  
Mal-Soon Shin ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Purkinje Cell ◽  
Motor Function ◽  
Treadmill Exercise ◽  
Cell Loss ◽  
Purkinje Cell Loss

scholarly journals Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23

Brain ◽  
2015 ◽  
Vol 138 (9) ◽  
pp. 2537-2552 ◽  
Author(s):  
Cleo J. L. M. Smeets ◽  
Justyna Jezierska ◽  
Hiroyuki Watanabe ◽  
Anna Duarri ◽  
Michiel R. Fokkens ◽  
...  
Keyword(s):  
Purkinje Cell ◽  
Spinocerebellar Ataxia ◽  
Cell Loss ◽  
Motor Dysfunction ◽  
Spinocerebellar Ataxia Type ◽  
Dynorphin A ◽  
Purkinje Cell Loss
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