scholarly journals Polymerization of Cholesteryl Methacrylate in the Mesophase

1972 ◽  
Vol 3 (3) ◽  
pp. 414-416 ◽  
Author(s):  
Hideo Saeki ◽  
Kazuyoshi Iimura ◽  
Masatami Takeda
Keyword(s):  
Cholesteryl Methacrylate

scholarly journals Liquid crystalline properties of cholesteryl methacrylate and butyl methacrylate copolymers.

1985 ◽  
Vol 42 (8) ◽  
pp. 489-494
Author(s):  
Kikuo SHOJI ◽  
Yukio NAKAJIMA ◽  
Eiichi UEDA ◽  
Masatami TAKEDA
Keyword(s):  
Liquid Crystalline ◽  
Butyl Methacrylate ◽  
Methacrylate Copolymers ◽  
Cholesteryl Methacrylate

Polymerization of mesomorphic monomers. I. Bulk polymerization of cholesteryl methacrylate

1972 ◽  
Vol 10 (4) ◽  
pp. 261-264 ◽  
Author(s):  
Yoshio Tanaka ◽  
Sanae Kabaya ◽  
Yukio Shimura ◽  
Akira Okada ◽  
Yoshie Kurihara ◽  
...  
Keyword(s):  
Bulk Polymerization ◽  
Cholesteryl Methacrylate

scholarly journals Thermal Optical Analysis of Cholesteryl Methacrylate and Butyl Methacrylate Copolymers

1985 ◽  
Vol 17 (9) ◽  
pp. 1029-1036
Author(s):  
Kikuo Shoji ◽  
Yukio Nakajima ◽  
Eiichi Ueda ◽  
Masatami Takeda
Keyword(s):  
Butyl Methacrylate ◽  
Optical Analysis ◽  
Methacrylate Copolymers ◽  
Cholesteryl Methacrylate

scholarly journals The endocytic pathway and therapeutic efficiency of doxorubicin conjugated cholesterol-derived polymers

2015 ◽  
Vol 3 (2) ◽  
pp. 323-335 ◽  
Author(s):  
Sema Sevimli ◽  
Sharon Sagnella ◽  
Alexander Macmillan ◽  
Renee Whan ◽  
Maria Kavallaris ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Methacrylic Acid ◽  
Endocytic Pathway ◽  
Potential Drug ◽  
Drug Delivery Vehicles ◽  
Therapeutic Efficiency ◽  
Delivery Vehicles ◽  
Cholesteryl Methacrylate

Previously synthesized poly(methacrylic acid-co-cholesteryl methacrylate) P(MAA-co-CMA) copolymers were examined as potential drug delivery vehicles.

scholarly journals Thermal Optical Analysis of Cholesteryl Methacrylate and Methyl Methacrylate Copolymers

1985 ◽  
Vol 17 (9) ◽  
pp. 997-1003 ◽  
Author(s):  
Kikuo Shoji ◽  
Yukio Nakajima ◽  
Eiichi Ueda ◽  
Masatami Takeda
Keyword(s):  
Methyl Methacrylate ◽  
Optical Analysis ◽  
Methacrylate Copolymers ◽  
Cholesteryl Methacrylate

scholarly journals Self-Assembled Nanoparticles Based on Block-Copolymers of Poly(2-deoxy-2-methacrylamido-d-glucose)/Poly(N-vinyl succinamic acid) with Poly(O-cholesteryl methacrylate) for Delivery of Hydrophobic Drugs

2021 ◽  
Vol 22 (21) ◽  
pp. 11457
Author(s):  
Mariia Levit ◽  
Alena Vdovchenko ◽  
Apollinariia Dzhuzha ◽  
Natalia Zashikhina ◽  
Elena Katernyuk ◽  
...  
Keyword(s):  
Block Copolymers ◽  
Chain Transfer ◽  
Aqueous Media ◽  
Spherical Shape ◽  
Amphiphilic Block Copolymers ◽  
Hydrodynamic Diameter ◽  
Amphiphilic Copolymers ◽  
Succinamic Acid ◽  
Cholesteryl Methacrylate

The self-assembly of amphiphilic block-copolymers is a convenient way to obtain soft nanomaterials of different morphology and scale. In turn, the use of a biomimetic approach makes it possible to synthesize polymers with fragments similar to natural macromolecules but more resistant to biodegradation. In this study, we synthesized the novel bio-inspired amphiphilic block-copolymers consisting of poly(N-methacrylamido-d-glucose) or poly(N-vinyl succinamic acid) as a hydrophilic fragment and poly(O-cholesteryl methacrylate) as a hydrophobic fragment. Block-copolymers were synthesized by radical addition–fragmentation chain-transfer (RAFT) polymerization using dithiobenzoate or trithiocarbonate chain-transfer agent depending on the first monomer, further forming the hydrophilic block. Both homopolymers and copolymers were characterized by 1H NMR and Fourier transform infrared spectroscopy, as well as thermogravimetric analysis. The obtained copolymers had low dispersity (1.05–1.37) and molecular weights in the range of ~13,000–32,000. The amphiphilic copolymers demonstrated enhanced thermal stability in comparison with hydrophilic precursors. According to dynamic light scattering and nanoparticle tracking analysis, the obtained amphiphilic copolymers were able to self-assemble in aqueous media into nanoparticles with a hydrodynamic diameter of approximately 200 nm. An investigation of nanoparticles by transmission electron microscopy revealed their spherical shape. The obtained nanoparticles did not demonstrate cytotoxicity against human embryonic kidney (HEK293) and bronchial epithelial (BEAS-2B) cells, and they were characterized by a low uptake by macrophages in vitro. Paclitaxel loaded into the developed polymer nanoparticles retained biological activity against lung adenocarcinoma epithelial cells (A549).

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