scholarly journals Determination of Sequence Distribution of Substituted and Unsubstituted Glucopyranose Units in Water-Soluble Cellulose Acetate Chain as Revealed by Enzymatic Degradation

1992 ◽  
Vol 24 (10) ◽  
pp. 1077-1097 ◽  
Author(s):  
Hideki Iijima ◽  
Keisuke Kowsaka ◽  
Kenji Kamide
Keyword(s):  
Cellulose Acetate ◽  
Enzymatic Degradation ◽  
Water Soluble ◽  
Sequence Distribution

Simultaneous Spectrophotometric Determination of Salbutamol by Coupling with Diazotized 4-Aminobenzoic acid

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Hind Hadi ◽  
Gufran Salim
Keyword(s):  
Pharmaceutical Preparations ◽  
Coupling Reaction ◽  
Dosage Forms ◽  
Water Soluble ◽  
Trace Determination ◽  
Aminobenzoic Acid ◽  
Optimum Conditions ◽  
Colored Product ◽  
Versus Concentration

A simple, rapid and sensitive spectrophotmetric method for trace determination of salbutamol (SAL) in aqueous solution and in pharmaceutical preparations is described. The method is based on the diazotization coupling reaction of the intended compound with 4-amino benzoic acid (ABA) in alkaline medium to form an intense orange, water soluble dye that is stable and shows maximum absorption at 410 nm. A graph of absorbance versus concentration indicates that Beer’s law is obeyed over the concentration range of 0.5-30 ppm, with a molar absorbtivity 3.76×104 L.mol-1 .cm-1 depending on the concentration of SAL. The optimum conditions and stability of the colored product have been investigated and the method was applied successfully to the determination of SAL in dosage forms.

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