Nerve Growth Factor Activity Detected in Equine Peripheral Blood of Horses with Fever after Truck Transportation.

1996 ◽  
Vol 7 (2) ◽  
pp. 43-46 ◽  
Author(s):  
Keiko KAWAMOTO ◽  
Hiroaki SATO ◽  
Masa-aki OIKAWA ◽  
Toyohiko YOSHIHARA ◽  
Mikihiro KANEKO ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Blood ◽  
Factor Activity ◽  
Nerve Growth ◽  
Truck Transportation

Nerve growth factor is preformed in and activates human peripheral blood eosinophils

1998 ◽  
Vol 102 (3) ◽  
pp. 454-460 ◽  
Author(s):  
Abraham Solomon ◽  
Luigi Aloe ◽  
Jacob Pe’er ◽  
Joseph Frucht-Pery ◽  
Stefano Bonini ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Blood ◽  
Human Peripheral Blood ◽  
Nerve Growth ◽  
Blood Eosinophils

A role for NGF and its receptors TrKA and p75NTR in the progression of COPD

2016 ◽  
Vol 397 (2) ◽  
pp. 157-163 ◽  
Author(s):  
Anna Stabile ◽  
Alessandra Pistilli ◽  
Lucia Crispoltoni ◽  
Claudia Montagnoli ◽  
Roberto Tiribuzi ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Pulmonary Disease ◽  
Peripheral Blood Mononuclear Cells ◽  
Peripheral Blood ◽  
Chronic Obstructive ◽  
Peripheral Blood Mononuclear ◽  
Obstructive Pulmonary Disease ◽  
Nerve Growth

Abstract Nerve growth factor and its receptors, TrkA and p75NTR, are involved in inflammation and airways diseases, but their role in chronic obstructive pulmonary disease is still unclear and not well investigated. our data indicate the stage dependent variation of nerve growth factor and its receptors in chronic obstructive pulmonary disease progression. In fact, for the first time, this study evaluates the presence of nerve growth factor and its receptors in serum and in peripheral blood mononuclear cells of patients with different stages of chronic obstructive pulmonary disease compared to healthy subjects, non-smoker and current smoker. Serum monocyte chemoattractant protein-1, tumor necrosis factor-α, interleukin-10 and forced expiratory volume in 1 s were also analyzed. Compared to healthy subjects, chronic obstructive pulmonary disease patients presented a staging-dependent increase in serum nerve growth factor, negatively correlated to forced expiratory volume in 1 s and positively to monocyte chemoattractant Protein-1. The percentage of p75NTR+ peripheral blood mononuclear cells increased in early stages of chronic obstructive pulmonary disease (I–II), while TrKA+ peripheral blood mononuclear cells increased in late stages (III–IV). Our data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging.

Nerve growth factor activity of several immunal related serine proteases

1998 ◽  
Vol 43 (22) ◽  
pp. 1886-1891
Author(s):  
Liying Guo ◽  
Hong Zhu ◽  
Yuancong Zhou
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Serine Proteases ◽  
Factor Activity ◽  
Nerve Growth

scholarly journals 2.5S nerve growth factor enhances survival, phagocytosis, and superoxide production of murine neutrophils

Blood ◽  
1991 ◽  
Vol 77 (6) ◽  
pp. 1320-1325 ◽  
Author(s):  
Y Kannan ◽  
H Ushio ◽  
H Koyama ◽  
M Okada ◽  
M Oikawa ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Blood ◽  
Superoxide Production ◽  
Colony Stimulating Factor ◽  
Nerve Growth ◽  
Zymosan A ◽  
Inflammatory Processes ◽  
Dose Dependent ◽  
Stimulating Factor

The effect of 2.5S nerve growth factor (NGF) on survival, phagocytosis, and superoxide production of murine neutrophils was examined and compared with the effects of interleukin-3 (IL-3) and recombinant GM colony-stimulating factor (rGM-CSF). NGF enhanced the viability of neutrophils isolated from peripheral blood and peritoneal cavity in a dose-dependent way. IL-3 50 U/mL had no effect. rGM-CSF 50 U/mL had an effect similar to that of 50 ng/mL NGF. NGF also enhanced the phagocytosis of hydrophilic microspheres by peritoneal neutrophils, and the activity of NGF was greater than that of IL-3 or rGM-CSF. NGF enhanced the superoxide production induced by phorbol 12-myristate 13- acetate (PMA), which acts at postreceptor sites, and that induced by opsonized zymosan, a receptor-mediated ligand. The stimulating activity of NGF was largely comparable to that of rGM-CSF. The present data show that NGF bound to neutrophils enhances their survival, phagocytosis, and superoxide production. Thus, we postulate that NGF plays an important role in the inflammatory processes.

A bryostatin-sensitive protein kinase C required for nerve growth factor activity

Biochemistry ◽  
1994 ◽  
Vol 33 (2) ◽  
pp. 542-551 ◽  
Author(s):  
Kuber R. Singh ◽  
Lori K. Taylor ◽  
Xueqiong Z. Campbell ◽  
Alan P. Fields ◽  
Kenneth E. Neet
Keyword(s):  
Protein Kinase C ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Protein Kinase ◽  
Factor Activity ◽  
Nerve Growth ◽  
Kinase C

scholarly journals 2.5S nerve growth factor enhances survival, phagocytosis, and superoxide production of murine neutrophils

Blood ◽  
1991 ◽  
Vol 77 (6) ◽  
pp. 1320-1325 ◽  
Author(s):  
Y Kannan ◽  
H Ushio ◽  
H Koyama ◽  
M Okada ◽  
M Oikawa ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Peripheral Blood ◽  
Superoxide Production ◽  
Colony Stimulating Factor ◽  
Nerve Growth ◽  
Zymosan A ◽  
Inflammatory Processes ◽  
Dose Dependent ◽  
Stimulating Factor

Abstract The effect of 2.5S nerve growth factor (NGF) on survival, phagocytosis, and superoxide production of murine neutrophils was examined and compared with the effects of interleukin-3 (IL-3) and recombinant GM colony-stimulating factor (rGM-CSF). NGF enhanced the viability of neutrophils isolated from peripheral blood and peritoneal cavity in a dose-dependent way. IL-3 50 U/mL had no effect. rGM-CSF 50 U/mL had an effect similar to that of 50 ng/mL NGF. NGF also enhanced the phagocytosis of hydrophilic microspheres by peritoneal neutrophils, and the activity of NGF was greater than that of IL-3 or rGM-CSF. NGF enhanced the superoxide production induced by phorbol 12-myristate 13- acetate (PMA), which acts at postreceptor sites, and that induced by opsonized zymosan, a receptor-mediated ligand. The stimulating activity of NGF was largely comparable to that of rGM-CSF. The present data show that NGF bound to neutrophils enhances their survival, phagocytosis, and superoxide production. Thus, we postulate that NGF plays an important role in the inflammatory processes.

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