scholarly journals Influence of exercise and emotional stresses on secretion of prolactin and growth hormone in Thoroughbred horses

2021 ◽  
Vol 32 (2) ◽  
pp. 49-53
Author(s):  
Tomoki KITAURA ◽  
Fumio SATO ◽  
Testuro HADA ◽  
Mutsuki ISHIMARU ◽  
Rumi KODAMA ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Thoroughbred Horses

scholarly journals Administration of bovine, porcine and equine growth hormone to the horse: effect on insulin-like growth factor-I and selected IGF binding proteins

2001 ◽  
Vol 171 (1) ◽  
pp. 163-171 ◽  
Author(s):  
SS De Kock ◽  
JP Rodgers ◽  
BC Swanepoel ◽  
AJ Guthrie
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Insulin Like Growth Factor ◽  
Protein Markers ◽  
Recombinant Growth Hormone ◽  
Igf Binding Proteins ◽  
Thoroughbred Horses ◽  
Igf I ◽  
Igf Binding ◽  
Time Required

This study investigated the biochemical effects of administration of three types of recombinant growth hormone (GH; somatotropin) to the Thoroughbred horse. Equine or bovine or porcine GH was administered at a recommended dosage to 3-5-year old Thoroughbred geldings, for up to 21 days. It was shown that, in addition to equine GH, bovine and porcine GH were active in the horse; however, porcine GH caused injection-site reactions that were so serious that administration had to be terminated. The concentrations of a range of GH-related serum protein markers were determined before, during and after the administration period. Because of the short half-life of GH itself, the objective was to identify GH-related markers that showed changes in concentration and which could be used as indicators of the abuse of these hormones. Among the possible markers identified, serum total insulin-like growth factor (IGF)-I was shown to be the most promising, increasing to 270% of the basal concentration for equine GH administration. After GH administration, IGF-I took longer to attain baseline concentrations than the time required for GH concentrations to recover to normal. The concentration obtained from the administration significantly exceeded natural concentrations for IGF-I, as was determined from a population of more than 2000 Thoroughbred horses in three continents. The concentrations of serum free IGF-I and IGF binding protein 3 (IGFBP-3) were also shown to be significantly affected by equine and bovine GH.

Association of pituitary adenoma with neuronal christoma: A TEM study

1994 ◽  
Vol 52 ◽  
pp. 232-233
Author(s):  
Eva Horvath ◽  
Kalman Kovacs ◽  
B. W. Scheithauer ◽  
R. V. Lloyd ◽  
H. S. Smyth
Keyword(s):  
Growth Hormone ◽  
Pituitary Adenoma ◽  
Pituitary Tumor ◽  
Nervous Tissue ◽  
Alternative Explanation ◽  
Growth Hormone Releasing Hormone ◽  
Cell Hyperplasia ◽  
Releasing Hormone ◽  
Secretory Neurons

The association of a pituitary adenoma with nervous tissue consisting of neuron-like cells and neuropil is a rare abnormality. In the majority of cases, the pituitary tumor is a chromophobic adenoma, accompanied by acromegaly. Histology reveals widely variable proportions of endocrine and nervous tissue in alternating or intermingled patterns. The lesion is perceived as a composite one consisting of two histogenetically distinct parts. It has been suggested that the neuronal component, morphologically similar to secretory neurons of the hypothalamus, may initiate adenoma formation by releasing stimulatory substances. Immunoreactivity for growth hormone releasing hormone (GRH) in the neuronal component of some cases supported this view, whereas other findings such as consistent lack of growth hormone (GH) cell hyperplasia in the lesions called for alternative explanation.Fifteen tumors consisting of a pituitary adenoma and a neuronal component have been collected over a 20 yr. period. Acromegaly was present in 11 patients, was equivocal in one, and absent in 3.

Target Growth Hormone Doses to IGF-1 Levels

2005 ◽  
Vol 39 (10) ◽  
pp. 10
Author(s):  
BETSY BATES
Keyword(s):  
Growth Hormone

Burned Children Benefit From Growth Hormone

2009 ◽  
Vol 40 (8) ◽  
pp. 38
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Growth Hormone
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