An association and meta-analysis study of 4 SNPs from beta-2 adrenergic receptor (ADRB2) gene with risk of asthma in children

2015 ◽  
Keyword(s):  
Adrenergic Receptor ◽  
Meta Analysis ◽  
Analysis Study ◽  
Adrb2 Gene ◽  
Asthma In Children ◽  
Beta 2

scholarly journals Beta-2 Adrenergic Receptor (ADRB2) Gene Polymorphisms and the Risk of Asthma: A Meta-Analysis of Case-Control Studies

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104488 ◽  
Author(s):  
Si-Qiao Liang ◽  
Xiao-Li Chen ◽  
Jing-Min Deng ◽  
Xuan Wei ◽  
Chen Gong ◽  
...  
Keyword(s):  
Adrenergic Receptor ◽  
Gene Polymorphisms ◽  
Meta Analysis ◽  
Case Control ◽  
Case Control Studies ◽  
Adrb2 Gene ◽  
Beta 2

Genetic Polymorphisms in the Promoter Region of the beta-2 Adrenergic Receptor Are Associated with the Early Response of Acute Lymphoblastic Leukemia to Chemotherapy.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 1959-1959
Author(s):  
Meyling H. Cheok ◽  
Cong Ding ◽  
Wenjian Yang ◽  
Somas Das ◽  
Dario Campana ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Lymphoblastic Leukemia ◽  
Adrenergic Receptor ◽  
Lymphoblastic Leukemia ◽  
Receptor Gene ◽  
High Dose ◽  
A Genome ◽  
Adrb2 Gene ◽  
Beta 2

Abstract Acute lymphoblastic leukemia (ALL) in children is a paradigm of disseminated cancer that is curable with chemotherapy, yet current treatment fails to cure about 20% of patients, for reasons that remain unknown. In a genome-wide assessment of in vivo treatment-induced changes in gene expression in ALL cells using the Affymetrix U95A and U133A oligonucleotide microarray, we found that patients who eventually relapsed did not up-regulate expression of the pro-apoptotic beta-2 adrenergic receptor gene (ADRB2) in their ALL cells after initial treatment with methotrexate and mercaptopurine. After treatment we observed a 5-fold lower level of ADRB2 gene expression in leukemia cells of patients who ultimately relapsed. We found a common genetic polymorphism in the ADRB2 promoter that was significantly linked to high-dose methotrexate induced up-regulation in ADRB2 gene expression in ALL cells. Moreover, the ADRB2 promoter haplotype was significantly linked to poor early treatment response in ALL cells from 242 children (i.e., probability of event-free survival at two years, p=0.0275 stratified by risk groups). These findings have revealed a germline polymorphism that is linked to the early antileukemic effects of ALL chemotherapy and provide new insights into genetic determinants of ALL treatment efficacy.

Beta-2 adrenergic receptor (ADRB2) gene polymorphism Arg16Gly as risk factor for osteoporosis

2017 ◽  
Author(s):  
Raquel Simoes ◽  
Joana Freitas ◽  
Ana Paula Barbosa ◽  
Mario Mascarenhas ◽  
Manuel Bicho
Keyword(s):  
Risk Factor ◽  
Gene Polymorphism ◽  
Adrenergic Receptor ◽  
Adrb2 Gene ◽  
Beta 2

scholarly journals Beta 2-adrenergic receptor gene association with overweight and asthma in children and adolescents and its relationship with physical fitness

2015 ◽  
Vol 33 (4) ◽  
pp. 381-386
Author(s):  
Neiva Leite ◽  
Leilane Lazarotto ◽  
Gerusa Eisfeld Milano ◽  
Ana Claudia Kapp Titski ◽  
Cássio Leandro Mühe Consentino ◽  
...  
Keyword(s):  
Physical Fitness ◽  
Children And Adolescents ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Gene Association ◽  
Asthma In Children ◽  
Beta 2 ◽  
Adrenergic Receptor Gene

scholarly journals The Influence of Beta-2 Adrenergic Receptor Gene Polymorphisms on Albuterol Therapy for Patients With Asthma: Protocol for a Systematic Review and Meta-Analysis

10.2196/14759 ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. e14759 ◽  
Author(s):  
Keiko Hikino ◽  
Shinobu Kobayashi ◽  
Erika Ota ◽  
Taisei Mushiroda ◽  
Tohru Kobayashi
Keyword(s):  
Systematic Review ◽  
Adrenergic Receptor ◽  
Literature Search ◽  
Meta Analysis ◽  
Current Evidence ◽  
Cochrane Central Register ◽  
Asthmatic Patients ◽  
Study Results ◽  
Adrb2 Gene ◽  
Meta Analyses

Background Albuterol is one of the most frequently used medications in clinical practice and seeing varying responses to albuterol between individuals is not uncommon. Multiple studies have been conducted to investigate the associations of differing responses due to albuterol, particularly with regards to the two nonsynonymous single nucleotide polymorphisms (SNPs) at positions 16 (Arg16Gly: substitution of arginine to glycine at position 16; rs1042713) and 27 (Glu27Gln: substitution of glutamic acid to glutamine at position 27; rs1042714) on the β-2 adrenergic receptor (ADRB2) gene. However, the directions of the correlations are conflicting. Objective The objective of this systematic review and meta-analysis is to assess the effect of the two SNPs on the ADRB2 gene, in terms of the responses that present in asthmatic patients shortly after albuterol inhalation. Methods The primary outcome of this work is a detailed study of the associations of the two SNPs in the ADRB2 gene with treatment response and lung function testing shortly after administration of albuterol to asthmatic patients. A comprehensive literature search, using the OVID platform, MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials, will be conducted by a specialized librarian without language restrictions. We will include both prospective and retrospective original observational studies, and we will exclude nonhuman or in vitro studies. All abstracts will be reviewed by two authors who will also individually perform data extraction from each eligible study. Any arising disagreements will be resolved through discussion with a third party. Risk of bias for all included studies will be independently assessed using the quality of genetic association studies tool. We will report the systematic review and meta-analysis, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. A narrative synthesis of study results or meta-analyses will be undertaken when appropriate. Results At the moment of writing, we have already started the preliminary literature search and piloting of the study selection process. The anticipated completion date is September 30, 2019. Conclusions Our systematic review and meta-analysis aims to clarify the current evidence of associations between the two nonsynonymous SNPs in the ADRB2 gene and the responses that present in asthmatic patients shortly after albuterol inhalation. If positive correlations are found, this knowledge may be used to improve personalized pharmacotherapy of albuterol use. Trial Registration PROSPERO CRD42019074554; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=74554 International Registered Report Identifier (IRRID) PRR1-10.2196/14759

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