scholarly journals Effects of multiparity on age-related changes in female wistar rats.

1993 ◽  
Vol 6 (2) ◽  
pp. 187-194
Author(s):  
Midori Yoshida ◽  
Yasuyuki Sanada ◽  
Ayako Suzuki ◽  
Kyoko Fujii ◽  
Ryoji Hokao
Author(s):  
Sergey Sudakov ◽  
Elena Alekseeva ◽  
Galina Nazarova ◽  
Valentina Bashkatova

The aim of this work was to study age-related changes in the behaviour of adult Wistar rats using the open field (OF) and elevated plus maze (EPM) tests. Behavioural changes related to motor activity and anxiety were of particular interest. Results showed that as male and female rats progressed from 2 to 5 months of age there was a decrease in the level of motor and exploratory activities, and an increase in the level of anxiety. Age-related changes were dependent upon initial individual characteristics of behaviour. For example, animals that demonstrated high motor activity at 2 months become significantly less active by 5 months, and animals that showed a low level of anxiety at 2 months become more anxious by 5 months. Low-activity and high-anxiety rats did not show any significant age-related changes in OF and EPM tests from 2 to 5 months of age, except for a decrease in the number of rearings in EPM. Significant individual differences in the behaviour of rats in OF and EPM tests observed at 2 months were not apparent by 5 months.


2021 ◽  
Vol 177 ◽  
pp. S130
Author(s):  
Tamara Popović ◽  
Jasmina Debeljak Martačić ◽  
Marija Glibetić ◽  
Silvio de Luka ◽  
Aleksander Trbovich

2014 ◽  
Vol 58 ◽  
pp. 19-29 ◽  
Author(s):  
S.J. Sokanovic ◽  
M.M. Janjic ◽  
N.J. Stojkov ◽  
A.Z. Baburski ◽  
M.M. Bjelic ◽  
...  

PLoS ONE ◽  
2011 ◽  
Vol 6 (4) ◽  
pp. e19194 ◽  
Author(s):  
Nady Braidy ◽  
Gilles J. Guillemin ◽  
Hussein Mansour ◽  
Tailoi Chan-Ling ◽  
Anne Poljak ◽  
...  

2018 ◽  
Vol 1 (4) ◽  
pp. 295-304 ◽  
Author(s):  
Olaoluwa Sesan Olukiran ◽  
Rufus Ojo Akomolafe ◽  
Olutosin Samuel Ilesanmi ◽  
Christian Eseigbe Imafidon ◽  
Quadri Kunle Alabi

1976 ◽  
Vol 231 (5) ◽  
pp. 1364-1370 ◽  
Author(s):  
MM Mullins ◽  
RO Banks

The ability of 6- to 7-, 12- to 13-, and 16- to 17-wk-old spontaneously hypertensive rats (SHR) to excrete an acutely administered, isotonic saline load (equivalent to 4.5% body wt) was evaluated. Female SHR from two different colonies were studied. Age-matched female Wistar (W) and Wistar-Kyoto (WKY) rats served as controls. At age 6 wk, the fraction of administered Na+ load excreted by either SHR colony after 60 min was significantly lower than in the Wistar rats but not significank, one colony of SHR excreted significantly more sodium after 60 min than the other rats. Glomerular filtration rate during control periods was positively correlated with age in one SHR colony; no age-related changes were observed in glomerular function in the other groups. These data 1) suggest that WKY rats are more appropriate than the Wistar rats as controls for renal function in the SHR, 2) demonstrate that the ability of the SHR to excrete an acutely administered sodium load is equal to or greater than normotensive WKY controls, and 3) demonstrate that with respect to renal function parameters, the SHR is not a homogenous strain.


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