scholarly journals A 90-day Feeding Toxicity Study of L-Serine in Male and Female Fischer 344 Rats

2010 ◽  
Vol 23 (1) ◽  
pp. 39-47 ◽  
Author(s):  
Yukie Tada ◽  
Norio Yano ◽  
Hiroshi Takahashi ◽  
Katsuhiro Yuzawa ◽  
Hiroshi Ando ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Fischer 344 Rats ◽  
Male And Female ◽  
Fischer 344

Central neurotoxicity induced by subchronic exposure to 2,4-pentanedione vapour

1995 ◽  
Vol 14 (8) ◽  
pp. 662-671 ◽  
Author(s):  
RH Garman ◽  
DE Dodd ◽  
B. Ballantyne
Keyword(s):  
Electron Microscopy ◽  
Vestibular Nuclei ◽  
Brain Lesions ◽  
Female Rats ◽  
Male Rats ◽  
Fischer 344 Rats ◽  
Male And Female ◽  
Fischer 344 ◽  
Peripheral Nerve Lesions ◽  
Microscopical Evidence

1 Male and female Fischer 344 rats were exposed to 2,4- pentanedione (2,4-PD) vapour acutely (4 h) at 1265 or 1811 ppm, or for 6 h day-1 , 5 days a week for 14 weeks to 0, 101, 307 or 650 ppm. 2 Mortality occurred during or within a few hours of the acute exposures (10% at 1265 ppm; 70% at 1811 ppm). No animal had gross or microscopic brain lesions. 3 All female rats (20) and 10 of 30 male rats exposed to 650 ppm 2,4-PD vapour died by the 38th study day (29 exposures); there were no subsequent male deaths. Twenty-five of the 30 animals that died, and seven of the 15 males that survived, had light microscopical evidence of degenerative lesions, principally within the caudate/putamen nuclei, nuclei of the cerebellar medulla, and vestibular nuclei. Less frequently involved, in animals that died, were various regions of the cerebral cortex. The early histopathological lesions, seen from the 16th study day (12 exposures) to the 38th study day (28 exposures) were characterised by malacia. When present, lesions in male rats surviving the 14-weeks of 650 ppm 2, 4-PD expo sure were characterised by malacia and gliosis. No peripheral nerve lesions were seen by light or transmis sion electron microscopy. 4 Neither mortality nor neuropathology were seen in rats subchronically exposed to 101 or 307 ppm, 2,4-PD vapour.

Evaluation of 13-Week Inhalation Toxicity Study on Methyl t-Butyl Ether (MTBE) in Fischer 344 Rats

1997 ◽  
Vol 17 (S1) ◽  
pp. S37-S44
Author(s):  
A. W. Lington ◽  
D. E. Dodd ◽  
S. A. Ridlon ◽  
J. F. Douglas ◽  
J. J. Kneiss ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Fischer 344 Rats ◽  
Butyl Ether ◽  
Fischer 344

Evaluation of 13-Week Inhalation Toxicity Study on Methyl t-Butyl Ether (MTBE) in Fischer 344 Rats

1997 ◽  
Vol 17 (S1) ◽  
pp. S37-S44 ◽  
Author(s):  
A. W. Lington ◽  
D. E. Dodd ◽  
S. A. Ridlon ◽  
J. F. Douglas ◽  
J. J. Kneiss ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Inhalation Toxicity ◽  
Fischer 344 Rats ◽  
Butyl Ether ◽  
Fischer 344

Pharmacokinetics of tertiary butyl alcohol in male and female Fischer 344 rats

1997 ◽  
Vol 92 (3) ◽  
pp. 179-186 ◽  
Author(s):  
Torka S. Poet ◽  
John L. Valentine ◽  
Susan J. Borghoff
Keyword(s):  
Butyl Alcohol ◽  
Tertiary Butyl Alcohol ◽  
Fischer 344 Rats ◽  
Tertiary Butyl ◽  
Male And Female ◽  
Fischer 344

Effects of subchronic d-fenfluramine on splenic immune functions in young and old male and female fischer 344 rats

1991 ◽  
Vol 13 (8) ◽  
pp. 1203-1212 ◽  
Author(s):  
J. Clancy ◽  
L.M. Petrovic ◽  
B.H. Gordon ◽  
R.J. Handa ◽  
D.B. Campbell ◽  
...  
Keyword(s):  
Fischer 344 Rats ◽  
Immune Functions ◽  
Male And Female ◽  
Fischer 344

scholarly journals A 28-day Gavage Toxicity Study in Male Fischer 344 Rats with 2-methylfuran

2013 ◽  
Vol 42 (2) ◽  
pp. 352-360 ◽  
Author(s):  
Santokh S. Gill ◽  
Meghan Kavanagh ◽  
Wendy Cherry ◽  
Michael Barker ◽  
Madeline Weld ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Fischer 344 Rats ◽  
Fischer 344

Fourteen-day Toxicity Study of 1,3,5-Trinitrobenzene in Fischer 344 Rats

1996 ◽  
Vol 16 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Tirumuru V. Reddy ◽  
Greg R. Olson ◽  
Barry Wiechman ◽  
Gunda Reddy ◽  
Merrel Robinson ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Fischer 344 Rats ◽  
Fischer 344
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