scholarly journals Effects of Endocrine Disrupting Chemicals with Estrogenic Activity on the Female Reproductive System in Rats

2001 ◽  
Vol 14 (1) ◽  
pp. 83-83 ◽  
Author(s):  
Midori Yoshida ◽  
Shin-ichi Katsuda ◽  
Akihiko Maekawa
Keyword(s):  
Reproductive System ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Female Reproductive System ◽  
Endocrine Disrupting

scholarly journals Molecular Basis for Endocrine Disruption by Pesticides Targeting Aromatase and Estrogen Receptor

2020 ◽  
Vol 17 (16) ◽  
pp. 5664 ◽  
Author(s):  
Chao Zhang ◽  
Tiziana Schilirò ◽  
Marta Gea ◽  
Silvia Bianchi ◽  
Angelo Spinello ◽  
...  
Keyword(s):  
Competitive Inhibition ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Binding Mode ◽  
Inhibition Mechanism ◽  
Aromatase Activity ◽  
Docking Simulations ◽  
Potential Binding ◽  
Endocrine Disrupting ◽  
17Β Estradiol

The intensive use of pesticides has led to their increasing presence in water, soil, and agricultural products. Mounting evidence indicates that some pesticides may be endocrine disrupting chemicals (EDCs), being therefore harmful for the human health and the environment. In this study, three pesticides, glyphosate, thiacloprid, and imidacloprid, were tested for their ability to interfere with estrogen biosynthesis and/or signaling, to evaluate their potential action as EDCs. Among the tested compounds, only glyphosate inhibited aromatase activity (up to 30%) via a non-competitive inhibition or a mixed inhibition mechanism depending on the concentration applied. Then, the ability of the three pesticides to induce an estrogenic activity was tested in MELN cells. When compared to 17β-estradiol, thiacloprid and imidacloprid induced an estrogenic activity at the highest concentrations tested with a relative potency of 5.4 × 10−10 and 3.7 × 10−9, respectively. Molecular dynamics and docking simulations predicted the potential binding sites and the binding mode of the three pesticides on the structure of the two key targets, providing a rational for their mechanism as EDCs. The results demonstrate that the three pesticides are potential EDCs as glyphosate acts as an aromatase inhibitor, whereas imidacloprid and thiacloprid can interfere with estrogen induced signaling.

scholarly journals In Vivo Testing System for Determining the Estrogenic Activity of Endocrine-Disrupting Chemicals(EDCs) in Goldfish (Carassius auratus).

2001 ◽  
Vol 47 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Hiroshi Ishibashi ◽  
Katsuyasu Tachibana ◽  
Mutsuyosi Tsuchimoto ◽  
Kiyoshi Soyano ◽  
Yasuhiro Ishibashi ◽  
...  
Keyword(s):  
Carassius Auratus ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Testing System ◽  
Goldfish Carassius Auratus ◽  
Endocrine Disrupting ◽  
In Vivo Testing

2D/2D Bi2WO6/Protonated g-C3N4 Step-scheme Heterojunctions for Enhancing Photodegradation of 17β-Estradiol: Promotional Role of Electrostatic Interaction

2022 ◽  
Author(s):  
Yashi Qing ◽  
Yanxiang Li ◽  
Dan Hu ◽  
Zhiwei Guo ◽  
Yujie Yang ◽  
...  
Keyword(s):  
Human Health ◽  
Electrostatic Interaction ◽  
Estrogenic Activity ◽  
Endocrine Disrupting Chemicals ◽  
Endocrine Disrupting ◽  
17Β Estradiol

17β-Estradiol (E2) is a type of endocrine disrupting chemicals (EDCs) with the strongest estrogenic activity which poses a huge threat to the ecosystems and human health even at extremely low...

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