scholarly journals Coexistence of Corticotroph Adenoma and Thyrotroph Hyperplasia in a Dog

2009 ◽  
Vol 71 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Takahiro TESHIMA ◽  
Yasushi HARA ◽  
Kae SHIGIHARA ◽  
Susumu TAKEKOSHI ◽  
Yoshinori NEZU ◽  
...  
Keyword(s):  
Corticotroph Adenoma ◽  
Thyrotroph Hyperplasia

Silent corticotroph adenoma: Experience with six cases

2020 ◽  
Author(s):  
Soler Guillermo Serra ◽  
Barceló Carlos Antich ◽  
Cubas Javier Bodoque ◽  
Fernández Honorato García ◽  
Bonet Antonio Mas ◽  
...  
Keyword(s):  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

Pituitary Adenomas that Produce Adrenocorticotropic Hormone and A-Subunit: Clinicopathological, Immunohistochemical, Ultrastructural, and Immunoelectron Microscopic Studies in Nine Cases

Neurosurgery ◽  
1990 ◽  
Vol 26 (3) ◽  
pp. 397-403 ◽  
Author(s):  
Kathryn K. Berg ◽  
Bernd W. Scheithauer ◽  
Ignacio Felix ◽  
Kalman Kovacs ◽  
Eva Horvath ◽  
...  
Keyword(s):  
Pituitary Adenomas ◽  
Adrenocorticotropic Hormone ◽  
Secretory Granules ◽  
Preoperative Evaluation ◽  
Periodic Acid ◽  
Periodic Acid Schiff ◽  
Double Labeling ◽  
Corticotroph Adenoma ◽  
A Subunit ◽  
Corticotroph Adenomas

Abstract Eight surgical and one autopsy specimen of pituitary adenomas (six cases of Cushing's disease, two of Nelson's syndrome. and one of hypopituitarism) were studied by histochemical, immunohistocytological, and ultrastructural methods. Eight tumors showed the characteristic histochemical profile of corticotroph adenoma—amphophilic to basophilic, and periodic acid-Schiff-positive to some extent. In all tumors, immunohistochemical studies revealed adrenocorticotropic hormone (ACTH) and à-subunit in the cytoplasm of some adenoma cells. By electron microscopy, seven tumors were found to be monomorphous; six were typical corticotroph adenomas and one was a subtype II silent corticotroph adenoma. One unique lesion was bimorphous—i.e., composed of corticotrophs as well as cells resembling glycoprotein cells. Immunoelectron microscopy by the double-labeling immunogold technique, performed on one corticotroph adenoma, demonstrated the presence of ACTH and à-subunit not only within the same adenoma cells but also within the same secretory granules. The cytogenesis of ACTH à-subunit tumors, a rare form of plurihormonal adenoma. remains to be elucidated. The duration of disease associated with these tumors exceeded the duration in patients with ordinary corticotroph adenomas. Given the low frequency with which increases in serum à-subunit are detectable in patients with such tumors—13% in this series—hormone production is not recognized at preoperative evaluation.

scholarly journals Clinical Significance of Radical Surgery in the Treatment of Silent Corticotroph Adenoma

2019 ◽  
Vol 62 (1) ◽  
pp. 114-122 ◽  
Author(s):  
Junhyung Kim ◽  
Seon Jin Yoon ◽  
Ju Hyung Moon ◽  
Cheol Ryong Ku ◽  
Se Hoon Kim ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Radical Surgery ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

scholarly journals A Case of Nonfunctioning Pituitary Adenoma Resembling So-called Silent Corticotroph Adenoma.

1997 ◽  
Vol 44 (2) ◽  
pp. 329-333 ◽  
Author(s):  
HIROMI SAKAGUCHI ◽  
HIROYUKI KOSHIYAMA ◽  
TOSHIAKI SANO ◽  
DAISUKE INOUE ◽  
NOBUO HASHIMOTO ◽  
...  
Keyword(s):  
Pituitary Adenoma ◽  
Nonfunctioning Pituitary Adenoma ◽  
Corticotroph Adenoma ◽  
Silent Corticotroph Adenoma

Ectopic Corticotroph Adenoma in the Cavernous Sinus: Case Report

Neurosurgery ◽  
1999 ◽  
Vol 45 (4) ◽  
pp. 914-918 ◽  
Author(s):  
Naoko Sanno ◽  
Shigeyuki Tahara ◽  
Yoichi Yoshida ◽  
Hiroyuki Onose ◽  
Ichiji Wakabayashi ◽  
...  
Keyword(s):  
Case Report ◽  
Cavernous Sinus ◽  
Corticotroph Adenoma
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