scholarly journals Adhesional Function of Canine Mammary Gland Tumor Cells Expressing Sialyl Lewis X

2009 ◽  
Vol 71 (9) ◽  
pp. 1225-1228 ◽  
Author(s):  
Takayuki NAKAGAWA ◽  
Yoshifumi ENDO ◽  
Manabu WATANABE ◽  
Manabu MOCHIZUKI ◽  
Ryohei NISHIMURA ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Tumor Cells ◽  
Sialyl Lewis X ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Lewis X ◽  
Sialyl Lewis ◽  
Canine Mammary Gland

scholarly journals LncRNA-42060 Regulates Tamoxifen Sensitivity and Tumor Development via Regulating the miR-204-5p/SOX4 Axis in Canine Mammary Gland Tumor Cells

2021 ◽  
Vol 8 ◽  
Author(s):  
Enshuang Xu ◽  
Mengxin Hu ◽  
Reidong Ge ◽  
Danning Tong ◽  
Yuying Fan ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Mammary Gland ◽  
Tumor Cells ◽  
Luciferase Reporter ◽  
Drug Resistant ◽  
Mammary Gland Tumor ◽  
Luciferase Reporter Gene ◽  
Gland Tumor ◽  
Canine Mammary Gland ◽  
Resistant Cells

Tamoxifen is the drug of choice for endocrine therapy of breast cancer. Its clinical use is limited by the development of drug resistance. There is increasing evidence that long non-coding RNAs (lncRNAs) are associated with tumor drug resistance. Therefore, we established two TAM-resistant cell lines, CHMpTAM and CHMmTAM. The different expression levels of lncRNA and miRNA in CHMmTAM and CHMm were screened by RNA sequencing, and the lncRNA-miRNA interactions were analyzed. LncRNA ENSCAFG42060 (lnc-42060) was found to be significantly upregulated in drug-resistant cells and tumor tissues. Further functional validation revealed that the knockdown of lnc-42060 inhibited proliferation, migration, clone formation, restoration of TAM sensitivity, and reduction of stem cell formation in drug-resistant cells, whereas overexpression of lnc-4206 showed opposite results. Bioinformatics and dual-luciferase reporter gene assays confirmed that lnc-42060 could act as a sponge for miR-204-5p, further regulating SOX4 expression activity and thus influencing tumor cell progression. In conclusion, we screened lncRNAs and miRNAs associated with TAM resistance in canine mammary gland tumor cells for the first time. lnc-42060 served as a novel marker that may be used as an important biomarker for future diagnosis and treatment.

scholarly journals 5-Azacytidine treatment induces demethylation of DAPK1 and MGMT genes and inhibits growth in canine mammary gland tumor cells

2018 ◽  
Vol Volume 11 ◽  
pp. 2805-2813 ◽  
Author(s):  
Xiaoli Ren ◽  
Huatao Li ◽  
Xianyi Song ◽  
Yuhong Wu ◽  
Yun Liu
Keyword(s):  
Mammary Gland ◽  
Tumor Cells ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Canine Mammary Gland

scholarly journals The Antiproliferative Effect of Bovine Lactoferrin on Canine Mammary Gland Tumor Cells

2008 ◽  
Vol 70 (5) ◽  
pp. 443-448 ◽  
Author(s):  
Yuichi YAMADA ◽  
Reeko SATO ◽  
Saori KOBAYASHI ◽  
Careen HANKANGA ◽  
Osamu INANAMI ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Tumor Cells ◽  
Antiproliferative Effect ◽  
Bovine Lactoferrin ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Canine Mammary Gland

Aspirin inhibits the proliferation of canine mammary gland tumor cells in vitro and in vivo

2017 ◽  
Vol 6 (1) ◽  
pp. 188-197 ◽  
Author(s):  
Chao Yang ◽  
Jia Liu ◽  
Yingxue Wang ◽  
Jinjin Tong ◽  
Yuhong Wu ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Tumor Cells ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Canine Mammary Gland

scholarly journals Significance of Tumor-Infiltrating Immune Cells in Spontaneous Canine Mammary Gland Tumor: 140 Cases

2012 ◽  
Vol 74 (2) ◽  
pp. 227-230 ◽  
Author(s):  
Kohei SAEKI ◽  
Yoshifumi ENDO ◽  
Kazuyuki UCHIDA ◽  
Ryohei NISHIMURA ◽  
Nobuo SASAKI ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Immune Cells ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Canine Mammary Gland

Relationship between NF-^|^kappa;B Expression and Malignancy of Canine Mammary Gland Tumor Tissues

2012 ◽  
Vol 74 (6) ◽  
pp. 713-718 ◽  
Author(s):  
Lobna MKAOUAR ◽  
Yoshifumi ENDO ◽  
He Xi JUN ◽  
Soo-Jung LEE ◽  
Tassanee JAROENSONG ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Tumor ◽  
Gland Tumor ◽  
Nf Kappa B ◽  
Tumor Tissues ◽  
Canine Mammary Gland

scholarly journals Natural killer cells attack tumor cells expressing high levels of sialyl Lewis x oligosaccharides

2002 ◽  
Vol 99 (21) ◽  
pp. 13789-13794 ◽  
Author(s):  
C. Ohyama ◽  
S. Kanto ◽  
K. Kato ◽  
O. Nakano ◽  
Y. Arai ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Tumor Cells ◽  
Sialyl Lewis X ◽  
Lewis X ◽  
Killer Cells ◽  
Sialyl Lewis
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