scholarly journals Inhibitory Effect of Newly Developed CXC-Chemokine Receptor 4 Antagonists on the Infection with Feline Immunodeficiency Virus

2009 ◽  
Vol 71 (1) ◽  
pp. 121-124 ◽  
Author(s):  
Fuminori MIZUKOSHI ◽  
Kenji BABA ◽  
Yuko GOTO-KOSHINO ◽  
Asuka SETOGUCHI-MUKAI ◽  
Yasuhito FUJINO ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Feline Immunodeficiency Virus ◽  
Inhibitory Effect ◽  
Cxc Chemokine Receptor 4 ◽  
Immunodeficiency Virus ◽  
Cxc Chemokine ◽  
Chemokine Receptor 4

scholarly journals Inhibitory effect of CXC chemokine receptor 4 antagonist AMD3100 on bleomycin induced murine pulmonary fibrosis

2010 ◽  
Vol 42 (6) ◽  
pp. 465 ◽  
Author(s):  
Jeong Sup Song ◽  
Chun Mi Kang ◽  
Hyeon Hui Kang ◽  
Hyung Kyu Yoon ◽  
Young Kyoon Kim ◽  
...  
Keyword(s):  
Pulmonary Fibrosis ◽  
Chemokine Receptor ◽  
Inhibitory Effect ◽  
Cxc Chemokine Receptor 4 ◽  
Cxc Chemokine ◽  
Chemokine Receptor 4

scholarly journals Bicyclams, Selective Antagonists of the Human Chemokine Receptor CXCR4, Potently Inhibit Feline Immunodeficiency Virus Replication

1999 ◽  
Vol 73 (8) ◽  
pp. 6346-6352 ◽  
Author(s):  
Herman F. Egberink ◽  
Erik De Clercq ◽  
Arno L. W. Van Vliet ◽  
Jan Balzarini ◽  
Gary J. Bridger ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Feline Immunodeficiency Virus ◽  
Drug Susceptibility ◽  
Cell System ◽  
Target Cells ◽  
Cxcr4 Antagonist ◽  
Immunodeficiency Virus ◽  
Cxc Chemokine ◽  
Stromal Cell Derived Factor ◽  
Chemokine Receptor 4

ABSTRACT Bicyclams are low-molecular-weight anti-human immunodeficiency virus (HIV) agents that have been shown to act as potent and selective CXC chemokine receptor 4 (CXCR4) antagonists. Here, we demonstrate that bicyclams are potent inhibitors of feline immunodeficiency virus (FIV) replication when evaluated in Crandell feline kidney (CRFK) cells. With a series of bicyclam derivatives, 50% inhibitory concentrations (IC50s) against FIV were obtained in this cell system that were comparable to those obtained for HIV-1 IIIB replication in the human CD4+ MT-4 T-cell line. The bicyclams were also able to block FIV replication in feline thymocytes, albeit at higher concentrations than in the CRFK cells. The prototype bicyclam AMD3100, 1-1′-[1,4-phenylene-bis(methylene)]-bis(1,4,8,11-tetraazacyclotetradecane), was only fourfold less active in feline thymocytes (IC50, 62 ng/ml) than in CRFK cells (IC50, 14 ng/ml). AMD2763, 1,1′-propylene-bis(1,4,8,11-tetraazacyclotetradecane), which is a less potent CXCR4 antagonist, was virtually inactive against FIV in feline thymocytes (IC50, >66.5 μg/ml), while it was clearly active in CRFK cells (IC50, 0.9 μg/ml). The CXC chemokine stromal-cell-derived factor 1α had anti-FIV activity in CRFK cells (IC50, 200 ng/ml) but not in feline thymocytes (IC50, >2.5 μg/ml). When primary FIV isolates were evaluated for their drug susceptibility in feline thymocytes, the bicyclams AMD3100 and its Zn2+ complex, AMD3479, inhibited all six primary isolates at equal potency. The marked susceptibility of FIV to the bicyclams suggests that FIV predominantly uses feline CXCR4 for entering its target cells.

CXC chemokine receptor 4 is expressed in uveal malignant melanoma and correlates with the epithelioid-mixed cell type

2007 ◽  
Vol 56 (10) ◽  
pp. 1589-1595 ◽  
Author(s):  
Stefania Scala ◽  
Caterina Ieranò ◽  
Alessandro Ottaiano ◽  
Renato Franco ◽  
Anna La Mura ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Chemokine Receptor ◽  
Cell Type ◽  
Mixed Cell ◽  
Cxc Chemokine Receptor 4 ◽  
Cxc Chemokine ◽  
Uveal Malignant Melanoma ◽  
Chemokine Receptor 4

scholarly journals Influence of chain length on the activity of tripeptidomimetic antagonists for CXC chemokine receptor 4 (CXCR4)

2017 ◽  
Vol 25 (2) ◽  
pp. 646-657 ◽  
Author(s):  
Markus Baumann ◽  
Mohammad Musarraf Hussain ◽  
Nina Henne ◽  
Daniel Moya Garrote ◽  
Stefanie Karlshøj ◽  
...  
Keyword(s):  
Chain Length ◽  
Chemokine Receptor ◽  
Cxc Chemokine Receptor 4 ◽  
Cxc Chemokine ◽  
Chemokine Receptor 4
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