scholarly journals Ultrastructural Study on the Differentiation and the Fate of M cells in Follicle-Associated Epithelium of Rat Peyer's Patch

2007 ◽  
Vol 69 (5) ◽  
pp. 501-508 ◽  
Author(s):  
Sachiko ONISHI ◽  
Toshifumi YOKOYAMA ◽  
Keigi CHIN ◽  
Midori YUJI ◽  
Tetsurou INAMOTO ◽  
...  
Keyword(s):  
Ultrastructural Study ◽  
M Cells ◽  
Peyer’S Patch ◽  
Peyer's Patch ◽  
Follicle Associated Epithelium

Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch

1987 ◽  
Vol 247 (3) ◽  
pp. 537-546 ◽  
Author(s):  
MarianR. Neutra ◽  
TeresaL. Phillips ◽  
EllenL. Mayer ◽  
DouglasJ. Fishkind
Keyword(s):  
M Cells ◽  
Peyer’S Patch ◽  
Peyer's Patch ◽  
Follicle Associated Epithelium ◽  
Membrane Bound

Uptake and transport of copolymer biodegradable microspheres by rabbit Peyer's patch M cells

1995 ◽  
Vol 279 (2) ◽  
pp. 433-436 ◽  
Author(s):  
Thomas H. Ermak ◽  
Edward P. Dougherty ◽  
Hitesh R. Bhagat ◽  
Zita Kabok ◽  
Jacques Pappo
Keyword(s):  
Biodegradable Microspheres ◽  
M Cells ◽  
Peyer’S Patch ◽  
Peyer's Patch ◽  
Uptake And Transport

scholarly journals Epithelial-mesenchymal transition of absorptive enterocytes and depletion of Peyer's patch M cells after PEDV infection

Virology ◽  
2021 ◽  
Vol 552 ◽  
pp. 43-51
Author(s):  
Ya-Mei Chen ◽  
Emma T. Helm ◽  
Jennifer M. Groeltz-Thrush ◽  
Nicholas K. Gabler ◽  
Eric R. Burrough
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
M Cells ◽  
Peyer’S Patch ◽  
Peyer's Patch ◽  
Mesenchymal Transition ◽  
Absorptive Enterocytes

scholarly journals Peyer's Patch-Deficient Mice Demonstrate That Mycobacterium avium subsp. paratuberculosis Translocates across the Mucosal Barrier via both M Cells and Enterocytes but Has Inefficient Dissemination

2010 ◽  
Vol 78 (8) ◽  
pp. 3570-3577 ◽  
Author(s):  
Luiz E. Bermudez ◽  
Mary Petrofsky ◽  
Sandra Sommer ◽  
Raúl G. Barletta
Keyword(s):  
Mycobacterium Avium ◽  
Intestinal Mucosa ◽  
Peyer's Patches ◽  
Mucosal Barrier ◽  
Peyer’S Patches ◽  
M Cells ◽  
Peyer’S Patch ◽  
Peyer's Patch ◽  
Mycobacterium Avium Subsp Paratuberculosis ◽  
Deficient Mice

ABSTRACT Mycobacterium avium subsp. paratuberculosis, the agent of Johne's disease, infects ruminant hosts by translocation through the intestinal mucosa. A number of studies have suggested that M. avium subsp. paratuberculosis interacts with M cells in the Peyer's patches of the small intestine. The invasion of the intestinal mucosa by M. avium subsp. paratuberculosis and Mycobacterium avium subsp. hominissuis, a pathogen known to interact with intestinal cells, was compared. M. avium subsp. paratuberculosis was capable of invading the mucosa, but it was significantly less efficient at dissemination than M. avium subsp. hominissuis. B-cell knockout (KO) mice, which lack Peyer's patches, were used to demonstrate that M. avium subsp. paratuberculosis enters the intestinal mucosa through enterocytes in the absence of M cells. In addition, the results indicated that M. avium subsp. paratuberculosis had equal abilities to cross the mucosa in both Peyer's patch and non-Peyer's patch segments of normal mice. M. avium subsp. paratuberculosis was also shown to interact with epithelial cells by an α5β1 integrin-independent pathway. Upon translocation, dendritic cells ingest M. avium subsp. paratuberculosis, but this process does not lead to efficient dissemination of the infection. In summary, M. avium subsp. paratuberculosis interacts with the intestinal mucosa by crossing both Peyer's patches and non-Peyer's patch areas but does not translocate or disseminate efficiently.

Keynote review: Intestinal Peyer's patch M cells and oral vaccine targeting

2005 ◽  
Vol 10 (17) ◽  
pp. 1145-1157 ◽  
Author(s):  
David J. Brayden ◽  
Mark A. Jepson ◽  
Alan W. Baird
Keyword(s):  
Oral Vaccine ◽  
M Cells ◽  
Peyer’S Patch ◽  
Peyer's Patch

scholarly journals Lymphocyte Depletion in Ileal Peyer’s Patch Follicles in Lambs Infected with Eimeria ovinoidalis

2002 ◽  
Vol 9 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Mona Aleksandersen ◽  
Kai-Inge Lie ◽  
Bjørn Gjerde ◽  
Thor Landsverk
Keyword(s):  
Carbonic Anhydrase ◽  
Peyer’S Patch ◽  
Peyer's Patch ◽  
Ki 67 ◽  
Lymphoid Follicles ◽  
Lymphocyte Depletion ◽  
Follicle Associated Epithelium ◽  
Follicle Size ◽  
Reticular Cells ◽  
Labeling Method

ABSTRACT A total of 14 lambs were experimentally infected with Eimeria ovinoidalis in two separate experiments in two consecutive years. Nine lambs served as uninoculated controls. Material was collected from the ileum 2 weeks after infection in eight lambs and 3 weeks after infection in six lambs. Lambs examined 2 weeks after infection had normal follicles. After three weeks, the follicle-associated epithelium covering the lymphoid follicles of the ileal Peyer’s patches showed fusions with adjacent absorptive epithelium, focal hyperplasia, and occasionally necrosis. Macrogametes, microgamonts, and oocysts were often found in the follicle-associated epithelium and the dome region. Various degrees of lymphocyte depletion were present in the ileal lymphoid follicles in all six infected lambs 3 weeks after infection, and four lambs had decreased follicle size. Reduced staining for leukocyte common antigen (CD45), B-cell markers, and the proliferation marker Ki-67 was present in these lambs. Application of the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick end labeling method for apoptotic cells revealed decreased staining in the ileal lymphoid follicles 3 weeks after infection. A marker of follicular dendritic cells, 5′- nucleotidase, showed increased reactivity, probably due to condensation of reticular cells following loss of follicle lymphocytes. Reduced staining for carbonic anhydrase in the follicle-associated epithelium and the domes was present in all six lambs examined 3 weeks after infection, indicating decreased production of carbonic anhydrase-reactive 50-nm particles and a decreased lymphoproliferative stimulus. In conclusion, the present study shows that severe E. ovinoidalis infection in lambs causes lesions of the follicle-associated epithelium and may result in lymphocyte depletion and atrophy of the ileal Peyer’s patch follicles.

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