scholarly journals Effects of Exposure to a 50 Hz Electric Field on Plasma Levels of Lactate, Glucose, Free Fatty Acids, Triglycerides and Creatine Phosphokinase Activity in Hind-Limb Ischemic Rats

2005 ◽  
Vol 67 (10) ◽  
pp. 969-974 ◽  
Author(s):  
Shinji HARAKAWA ◽  
Noboru INOUE ◽  
Takuya HORI ◽  
Koji TOCHIO ◽  
Tatsuya KARIYA ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Electric Field ◽  
Free Fatty Acids ◽  
Plasma Levels ◽  
Hind Limb ◽  
Creatine Phosphokinase

Plasma levels of free fatty acids correlate with type 2 diabetes mellitus

2018 ◽  
Vol 20 (11) ◽  
pp. 2661-2669 ◽  
Author(s):  
Sandro Spiller ◽  
Matthias Blüher ◽  
Ralf Hoffmann
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Acids ◽  
Type 2 Diabetes Mellitus ◽  
Free Fatty Acids ◽  
Plasma Levels

Hormonal dose–response to an adenosine receptor agonist

1994 ◽  
Vol 72 (2) ◽  
pp. 113-116 ◽  
Author(s):  
Jacques LeBlanc ◽  
Julie Soucy
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Adenosine Receptor ◽  
Plasma Levels ◽  
Receptor Agonist ◽  
Insulin Response ◽  
Male Rats ◽  
Normal Ranges ◽  
Adenosine Receptor Agonist ◽  
Pituitary Adrenal Axis

The effect of various doses of i.p. injection of the adenosine receptor agonist (R)-phenylisopropyladenosine (R-PIA), ranging from nanomolar to micromolar concentrations, on plasma levels of free fatty acids, glucose, insulin, glucagon, ACTH, and corticosterone was examined in 200-g male rats. At the lowest dose of R-PIA (0.005 μmol/kg), a marked decrease in plasma insulin and free fatty acids was observed. This effect on free fatty acids persisted up to the highest concentration of R-PIA (50 μmol/kg). The insulin response showed a similar pattern except at the highest concentration, when the plasma levels were within normal ranges. A 100% increase in plasma glucose was found, but only with doses of 0.5 μmol/kg and above, suggesting an A2 receptor influence, possibly related to the elevation of plasma glucagon observed with the same doses of R-PIA. It has been shown that caffeine, an antagonist of adenosine, stimulates the pituitary–adrenal axis. Surprisingly, it was shown that R-PIA produces the same effect, as evidenced by the marked elevation of both plasma ACTH and corticosterone at concentrations of 0.5 μmol/kg and higher. It is suggested that this centrally mediated effect is due to a primary peripheral action.Key words: adenosine, glucose, free fatty acids, insulin, glucagon, ACTH, corticosterone.

Effects of Graded Insulin Infusions on Plasma Levels of Free Fatty Acids, Adrenaline and Noradrenaline Directly After Open Heart Surgery

1987 ◽  
Vol 35 (02) ◽  
pp. 96-100 ◽  
Author(s):  
F. Nilsson ◽  
E. Berglin W-O ◽  
R. Ekroth ◽  
G. Holm ◽  
I. Milocco ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Free Fatty Acids ◽  
Plasma Levels ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart

scholarly journals Plasma Levels of Free Fatty Acids in Women with Gestational Diabetes and Its Intrinsic and Extrinsic Determinants: Systematic Review and Meta-Analysis

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Jose Rafael Villafan-Bernal ◽  
Mariana Acevedo-Alba ◽  
Rodrigo Reyes-Pavon ◽  
Guillermo Andres Diaz-Parra ◽  
Diana Lucia Lip-Sosa ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gestational Diabetes ◽  
Free Fatty Acids ◽  
Pregnant Women ◽  
Plasma Levels ◽  
Meta Analysis ◽  
Nonesterified Fatty Acids ◽  
Induce Insulin Resistance ◽  
The Mean ◽  
The Difference

Background. Free fatty acids, also known as nonesterified fatty acids, are proinflammatory molecules that induce insulin resistance in nonpregnant individuals. Nevertheless, the concentration of these molecules has not been systematically addressed in pregnant women. Objective. This meta-analysis is aimed at evaluating the difference in free fatty acid plasma levels between women with gestational diabetes and healthy pregnant controls and their intrinsic and extrinsic determinants. Methods. We performed a systematic search to find relevant studies published in English and Spanish using PubMed, SCOPUS, and ISI Web of Knowledge. We included observational studies measuring the mean plasma levels of free fatty acids among gestational diabetes and healthy pregnant women, with at least ten subjects being analyzed in each group. The standardized mean difference (SMD) by random effects modeling was used. Heterogeneity was assessed using Cochran’s Q, H, and I2 statistics. Results. Among the 290 identified studies, twelve were selected for analysis. A total of 2426 women were included, from which 21% were diagnosed as having gestational diabetes. There were significantly higher levels of free fatty acids among women with gestational diabetes (SMD: 0.86; 0.54-1.18; p<0.001) when compared to healthy pregnant controls and between-study heterogeneity (I2=91%). The metaregression analysis showed that the gestational age at inclusion was the only cofactor influencing the mean levels of free fatty acids, indicating a trend towards lower plasma levels of free fatty acids later in gestation (estimate: -0.074; -0.143 to -0.004; p=0.036). No significant publication bias was found nor a trend towards greater results in small studies. Conclusions. Women with gestational diabetes have higher levels of free fatty acids when compared to healthy pregnant controls. More investigation is needed to assess the potential role of free fatty acids in the prediction of gestational diabetes earlier in pregnancy.

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