scholarly journals Seasonal Changes of Testicular Weight, Sperm Production, Serum Testosterone, and in Vitro Testosterone Release in Korean Ring-Necked Pheasants(Phasianus colchicus karpowi).

2001 ◽  
Vol 63 (2) ◽  
pp. 151-156 ◽  
Author(s):  
In Shik KIM ◽  
Hong Hyun YANG
Keyword(s):  
Seasonal Changes ◽  
Serum Testosterone ◽  
Phasianus Colchicus ◽  
Sperm Production ◽  
Testicular Weight

Initiation of spermatogenesis and testicular growth in oestradiol-17β-implanted bull calves with pulsatile infusion of luteinizing hormone releasing hormone

1982 ◽  
Vol 93 (2) ◽  
pp. 183-NP ◽  
Author(s):  
B. D. Schanbacher ◽  
M. J. D'Occhio ◽  
J. E. Kinder
Keyword(s):  
Pubertal Development ◽  
Serum Testosterone ◽  
Sperm Production ◽  
Releasing Hormone ◽  
Testicular Growth ◽  
Bull Calves ◽  
Testicular Weight ◽  
Additional Support ◽  
Lh Rh ◽  
Lh Releasing Hormone

Testicular growth and secretory profiles of LH and testosterone were monitored in three bull calves implanted with oestradiol-17β and three bull calves implanted with oestradiol-17β and infused intravenously with LH releasing hormone (LH-RH; 500 ng/pulse per h, 30-s pulse) continuously between 34 and 42 weeks of age. Oestradiol-17β implants restricted testicular growth and spermatogenesis by interfering with the hypothalamo-pituitary-testicular endocrine axis. Initiation of pulsatile LH release by LH-RH pulse infusion was accompanied by a twofold increase in mean circulating levels of LH (3·4 v. 1·8 μg/l) and a marked increase in serum testosterone (13·0 v. 0·4 μg/l). Testicular diameter was enhanced significantly by week 4 of infusion and increased in a linear fashion up to and including week 8. Testicular weight (g) and total daily sperm production (× 109) at 42 weeks of age were decreased in calves implanted with oestradiol-17β (105 ± 14 (s.e.m.); 0·0) when compared with calves implanted with oestradiol-17β and infused with LH-RH (254 ± 12; 1·2 ± 0·3). Differences in testicular size and sperm production rates between LH-RH-infused and control bulls without implants (352 ± 26; 3·3 ± 0·9) were attributed to the 2-month delay between oestradiol-17β treatment and the initiation of LH-RH treatment. These results (1) confirm our earlier conclusion that oestradiol-17β can interfere with normal pubertal development in beef bulls and (2) provide additional support that pulsatile LH secretion is important for the initiation of testicular growth and spermatogenesis in pubertal bulls.

Prepubertal treatment of rats with clomiphene citrate affects postpubertal testicular development

1989 ◽  
Vol 120 (4) ◽  
pp. 423-428 ◽  
Author(s):  
Janine L. Brown ◽  
Prabir K. Chakraborty
Keyword(s):  
Cell Function ◽  
Clomiphene Citrate ◽  
Serum Testosterone ◽  
Normal Serum ◽  
Gnrh Receptor ◽  
Testicular Development ◽  
Fsh Receptor ◽  
Sperm Production ◽  
Testicular Weight ◽  
Daily Sperm Production

Abstract. A previous study showed that clomiphene citrate (clomiphene) reduced serum and pituitary gonadotropins and impaired testis growth and steroidogenesis in 10-day-old rats treated for up to two weeks. The present study was conducted to assess the effect of prepubertal clomiphene treatment on postpubertal pituitary-testicular function. Rats were implanted with pellets that released 0, 0.05, 0.5 or 5.0 mg clomiphene ·kg−1·day−1 between 10–31 days of age and were killed at 90 days of age. Testis and prostate weights in treated rats were reduced (P< 0.05), whereas serum LH, FSH and testosterone, and pituitary gonadotropin and GnRH receptor concentrations had recovered to levels observed in control rats. Testicular FSH receptor concentrations were not altered; however, FSH receptor content was decreased (P< 0.05) in clomiphene-treated rats proportional to the reduction in testicular weight. In contrast, testicular LH and GnRH receptor concentrations were increased (P< 0.05) in treated animals, resulting in similar receptor contents. Daily sperm production per gram of parenchyma was unaffected, while daily sperm production per testis was decreased in treated rats (P< 0.05). These data show early postnatal treatment with clomiphene does not permanently impair pituitary function. Despite reduced testicular mass, normal serum testosterone concentrations and testis LH receptor content of treated rats suggest recovered Leydig cell function. The decreased content of testicular FSH receptors and reduced sperm production suggest seminiferous tubule function was compromised in the adult rat.

scholarly journals Testosterone level, nasal gland volume and Leydig cell morphometry in capybaras (Hydrochoerus hydrochaeris)

2006 ◽  
Vol 58 (6) ◽  
pp. 1086-1091 ◽  
Author(s):  
D.S. Costa ◽  
T.A.R. Paula
Keyword(s):  
Cell Volume ◽  
Leydig Cell ◽  
Gonadosomatic Index ◽  
Serum Testosterone ◽  
Volume Density ◽  
Testosterone Concentration ◽  
Gland Volume ◽  
Testicular Weight ◽  
Hydrochoerus Hydrochaeris ◽  
Proportional Increase

The testosterone levels with nasal gland volume and Leydig cell morphometry in sexually mature capybaras were compared using 10 adult capybaras, aging 28 months. Body and testicular weight were 50kg and 28g, respectively. The gonadosomatic index was 0.11±0.02%, while nasal gland volume was 34.12±13.04ml. Serum testosterone concentration was 25.07±14.73ng/ml. Leydig cell volume density and leydigosomatic index were, respectively, 28.8±8.3% and 0.030±0.007%. Total and individual Leydig cell volumes were 6.88±1.92ml and 2,228.14±272.59x10-12ml, respectively. Leydig cell numbers per testis and per gram of testis were, respectively, 3,079.4±719.9x10(6) and 115.09±31.78x10(6) cells. These results show that increase in serum testosterone concentration is correlated to a proportional increase of nasal gland and Leydig cell volume in capybaras.

scholarly journals Protective Effect of Decursin Extracted fromAngelica gigasin Male Infertility via Nrf2/HO-1 Signaling Pathway

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Woong Jin Bae ◽  
U. Syn Ha ◽  
Jin Bong Choi ◽  
Kang Sup Kim ◽  
Su Jin Kim ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Semen Quality ◽  
Antioxidant Activities ◽  
Control Group ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Dependent Manner ◽  
Testicular Weight ◽  
Unilateral Cryptorchidism

Higher testicular temperature results in altered spermatogenesis due to heat-related oxidative stress. We examined the effects of decursin extracted fromAngelica gigasNakai on antioxidant activityin vitroand in a cryptorchidism-induced infertility rat model. TM3 Leydig cell viability was measured based on oxidative stress according to treatment. Either distilled water or AG 400 mg/kg ofA. gigasextract was administered orally for 4 weeks after unilateral cryptorchidism was induced. After 1, 2, and 4 weeks, six rats from the control group and six rats from treatment group were sacrificed. Testicular weight, semen quality, antioxidant activities, nuclear factor erythroid 2-related factor 2 (Nrf2) protein, and mRNA expression of Nrf2-regulated genes were analyzed. Treatment withA. gigasextract (1) protected TM3 cells against oxidative stress in a dose-dependent manner, (2) improved the mean weight of the cryptorchid testis, (3) maintained sperm counts, motility, and spermatogenic cell density, (4) decreased levels of 8-hydroxy-2-deoxyguanosine (8-OHdG) and increased levels of superoxide dismutase (SOD), (5) significantly increased Nrf2 and heme oxygenase-1 (HO-1), and (6) significantly decreased apoptosis. This study suggests that decursin extracted fromA. gigasis a supplemental agent that can reduce oxidative stress by Nrf2-mediated upregulation of HO-1 in rat experimentally induced unilateral cryptorchidism and may improve cryptorchidism-induced infertility.

scholarly journals Photoperiodic regulation of prolactin secretion: changes in intra-pituitary signalling and lactotroph heterogeneity

2004 ◽  
Vol 180 (3) ◽  
pp. 351-356 ◽  
Author(s):  
JD Johnston
Keyword(s):  
Environmental Conditions ◽  
Seasonal Changes ◽  
Mammalian Species ◽  
Prolactin Secretion ◽  
Day Length ◽  
Pars Tuberalis ◽  
Photoperiodic Regulation ◽  
Pituitary Lactotroph

Many mammalian species utilise day-length (photoperiod) to adapt their physiology to seasonal changes in environmental conditions, via secretion of pineal melatonin. Photoperiodic regulation of prolactin secretion is believed to occur via melatonin-mediated changes in the secretion of a putative prolactin secretagogue, tuberalin, from the pituitary pars tuberalis. Despite the in vivo and in vitro evidence in support of this intra-pituitary signalling mechanism, the identity of tuberalin has yet to be elucidated. This paper reviews recent advances in the characterisation of tuberalin and the regulation of its secretion. Furthermore, the hypothesis that pituitary lactotroph cells display heterogeneity in their response to changing photoperiod and tuberalin secretion is examined.

scholarly journals Should azoospermic patients with varicocele disease undergo surgery to recover fertility?

2017 ◽  
Vol 63 (4) ◽  
pp. 332-335 ◽  
Author(s):  
Leonardo de Souza Alves ◽  
Francisco Batista de Oliveira
Keyword(s):  
Sperm Count ◽  
Semen Analysis ◽  
Production Method ◽  
Obstructive Azoospermia ◽  
Sperm Production ◽  
Genetic Changes ◽  
Donor Sperm ◽  
Vitro Fertilization ◽  
Positive Rate

Summary Introduction: Varicocele disease is well-known cause of infertility in men. The presence of spermatic varices veins create a hostile environment to spermatogenesis. It results in reduced quality of the sperm production and in some cases can determine a total absence of sperm. The varicocelectomy procedure in patients with non-obstructive azoospermia (NOA) can raise the rates of sperm in the semen analysis. A positive rate for sperm, even if very low, may be sufficient to enable the capture of sperm intended for in-vitro fertilization without the use of donor sperm. Objetive: To evaluate the raise of sperm in NOA patients with varicocele disease who were submitted to a bilateral procedure to recovery sperm production. Method: We analized the sperm results of 25 NOA patients who undergone to a bilateral varicocelectomy procedure. Results: From a total of 25 patients, three (12%) recovered sperm count four months after procedure. One year after the procedure, five (20%) patients recovered sperm production. Conclusion: Patients with varicocele disease and azoospermia, without genetic changes or obstruction of the spermatic tract, should undergo surgical procedure to recover sperm.

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