Effects of Vitamin D3 Injection on Activity of Thyroid Parafollicular Cells in Pregnant Rats.

1996 ◽  
Vol 58 (1) ◽  
pp. 75-76
Author(s):  
Jong-Han WON ◽  
Kazuyuki TANIGUCHI ◽  
Reeko SATO ◽  
Yoshihisa NAITO
Keyword(s):  
Vitamin D3 ◽  
Pregnant Rats ◽  
Parafollicular Cells

scholarly journals The effects of vitamin D3 on lipogenesis in the liver and adipose tissue of pregnant rats

2015 ◽  
Vol 36 (4) ◽  
pp. 1151-1158 ◽  
Author(s):  
EUN-JIN KANG ◽  
JAE-EON LEE ◽  
SUNG-MIN AN ◽  
JAE HO LEE ◽  
HYEOG SOONG KWON ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Vitamin D3 ◽  
Pregnant Rats

scholarly journals Effect of Oral Vitamin D3 Supplements on Lipid Profile and Oxidative Stress in Adult Albino Female Rats

2019 ◽  
Vol 9 (04) ◽  
pp. 686-688
Author(s):  
Khder N Abdulla ◽  
Muneef S. Ahmed ◽  
Saleh Mohammed R
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
Vitamin D3 ◽  
Pregnant Female ◽  
Female Rats ◽  
Control Group ◽  
Low Density ◽  
Pregnant Rats ◽  
And Oxidative Stress ◽  
Albino Female

The present study was designed to show the effect of Vitamin D3 on lipid profile and oxidative stress. The present study used 30 adult albino female rats that distributed to following groups (each group consist 6 rats); control group received ad libidium, second group administrated Vitamin D3 (orally, 8.9μg/kg) for eight weeks, third group administrated Vitamin D3 (orally, 17.8μg/kg) for eight weeks, fourth group (pregnant rats) administrated Vitamin D3 (orally, 8.9μg/k) for eight weeks, fifth group (pregnant rats) administrated Vitamin D3 (orally, 17.8μg/kg) for eight weeks, and then killed. The results showed high significant increased (P less than 0.05) in levels of lipid profile (total cholesterol, total glyceride, high density lipid (HDL), low density lipid (LDL) very low density lipid (VLDL)), especially in pregnant female rats (third and fifth groups) compared with control group. On the other hand, the results showed significant changes (P less than 0.05) in levels of malondialdehyde (MDA), Superoxide dismutase (SOD) and catalase especially in pregnant female rats (third and fifth groups) compared with control group. It was concluded that the prolong using and overdose of Vitamin D3 lead to elevated the lipid profile and oxidative stress in rats especially in pregnant female rats.

scholarly journals Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D3 Supplementation in High Iodide Intake–Induced Hypothyroid Offspring Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Qing Liu ◽  
Yue Zhang ◽  
Hailing Zhao ◽  
Xiaomei Yao
Keyword(s):  
Fatty Acids ◽  
Thyroid Function ◽  
Vitamin D3 ◽  
Cardiac Dysfunction ◽  
Density Lipoprotein ◽  
Thyroid Peroxidase ◽  
Thyroid Function Tests ◽  
Free Triiodothyronine ◽  
Pregnant Rats ◽  
Hydroxyeicosatetraenoic Acids

Aim: This study aimed to investigate the potential role of fatty acids in high iodide intake–induced hypothyroidism and its complications and also in the intervention of iodide intake adjustment and 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] supplementation.Methods: Pregnant rats were allocated to two groups, namely, normal iodide (NI, 7.5 μg/day) intake and 100 times higher-than-normal iodide (100 HI, 750 μg/day) intake. The offspring were continuously administered potassium iodide from weaning [i.e., postnatal day 21 (PN21)] to PN90. After PN90, the offspring were either administered iodide intake adjustment (7.5 μg/day) or 1,25(OH)2D3 supplementation (5 μg·kg−1·day−1), or both, for 4 weeks. Thyroid function tests (free triiodothyronine, free thyroxine, thyrotropin, thyroid peroxidase antibody, and thyroglobulin antibody), blood lipids (triglyceride, total cholesterol, free fatty acid, and low-density lipoprotein cholesterol), and vitamin D3 (VD3) levels were detected by ELISA. Cardiac function was measured by echocardiography. Blood pressure was measured using a non-invasive tail-cuff system. The serum fatty acids profile was analyzed by liquid chromatography–mass spectrometry.Results: In the offspring rats with continued 100 HI administration, the levels of 8,9-dihydroxyeicosatrienoic acid (8,9-DHET) and thromboxane B2 (TXB2) were decreased, while those of prostaglandin J2 (PGJ2), prostaglandin B2 (PGB2), 4-hydroxydocosahexaenoic acid (4-HDoHE), 7-HDoHE, 8-HDoHE, and 20-HDoHE were increased. Significant correlations were found between PGB2, 8,9-DHET, 7-HDoHE levels and thyroid dysfunction, between PGJ2, 20-HDoHE, PGB2, 8,9-DHET levels and cardiac dysfunction, between PGJ2, 20-HDoHE levels and hypertension, between 4-HDoHE, 8-HDoHE, TXB2 levels and dyslipidemia, and between PGB2 and decreased VD3 level. After the treatment of iodide intake adjustment and 1,25(OH)2D3 supplementation, the levels of 16-hydroxyeicosatetraenoic acids (16-HETE), 18-HETE, 5,6-epoxyeicosatrienoic acid (5,6-EET), 8,9-EET, 11,12-EET, 14,15-EET, PGE2, 5-oxo-ETE, and 15-oxo-ETE were increased. The significant associations between PGE2, 16-HETE, 18-HETE and improved thyroid function and also between 5,6-EET, 11,12-EET, 14,15-EET, 16-HETE, 15-oxo-ETE and attenuated dyslipidemia were detected.Conclusion: Increased levels of prostaglandins (PGs) and HDoHEs and decreased levels of 8,9-DHET and TXB2 might occur in the progression of cardiac dysfunction, hypertension, and dyslipidemia in high iodide intake–induced hypothyroidism. The increased levels of EETs and HETEs might help to ameliorate these complications after iodide intake adjustment and 1,25(OH)2D3 supplementation.

Modification of Pineal Ultrastructure by Exogenous Hormones

1967 ◽  
Vol 25 ◽  
pp. 170-171
Author(s):  
R. A. Turner ◽  
A. E. Rodin ◽  
D. K. Roberts
Keyword(s):  
Electron Microscopy ◽  
Endoplasmic Reticulum ◽  
Rough Endoplasmic Reticulum ◽  
Estradiol Benzoate ◽  
Female Rats ◽  
List Type ◽  
Type Number ◽  
Pregnant Rats ◽  
Gonadal Atrophy ◽  
Pineal Ultrastructure

There have been many reports which establish a relationship between the pineal and sexual structures, including gonadal hypertrophy after pinealectomy, and gonadal atrophy after injection of pineal homogenates or of melatonin. In order to further delineate this relationship the pineals from 5 groups of female rats were studied by electron microscopy:ControlsPregnant ratsAfter 4 weekly injections of 0.1 mg. estradiol benzoate.After 8 daily injections of 150 mcgm. melatonin (pineal hormone).After 8 daily injections of 3 mg. serotonin (melatonin precursor).No ultrastructural differences were evident between the control, and the pregnancy and melatonin groups. However, the estradiol injected animals exhibited a marked increase in the amount and size of rough endoplasmic reticulum within the pineal cells.

1216: Oral Treatment with a Vitamin D3 Analogue Shows Anti Inflammatory Effects and Reduces Bladder Overactivity in Rodent Models of Chronic Cystitis

2005 ◽  
Vol 173 (4S) ◽  
pp. 330-330
Author(s):  
Peter Zvara ◽  
Fabio Benigni ◽  
Enrico Baroni ◽  
Marija Zecevic ◽  
Antonia Monno ◽  
...  
Keyword(s):  
Vitamin D3 ◽  
Oral Treatment ◽  
Rodent Models ◽  
Chronic Cystitis ◽  
Anti Inflammatory

Vitamin D3 supplementation improves glycemic control in type 2 diabetic patients: Results from an Italian clinical trial

2020 ◽  
pp. 1-10
Author(s):  
Giuseppe Derosa ◽  
Angela D’Angelo ◽  
Chiara Martinotti ◽  
Maria Chiara Valentino ◽  
Sergio Di Matteo ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Metabolic Control ◽  
Vitamin D3 ◽  
Therapy Group ◽  
Hypoglycemic Agents ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Type 2 Diabetic

Abstract. Background: to evaluate the effects of Vitamin D3 on glyco-metabolic control in type 2 diabetic patients with Vitamin D deficiency. Methods: one hundred and seventeen patients were randomized to placebo and 122 patients to Vitamin D3. We evaluated anthropometric parameters, glyco-metabolic control, and parathormone (PTH) value at baseline, after 3, and 6 months. Results: a significant reduction of fasting, and post-prandial glucose was recorded in Vitamin D3 group after 6 months. A significant HbA1c decrease was observed in Vitamin D3 (from 7.6% or 60 mmol/mol to 7.1% or 54 mmol) at 6 months compared to baseline, and to placebo (p < 0.05 for both). At the end of the study period, we noticed a change in the amount in doses of oral or subcutaneous hypoglycemic agents and insulin, respectively. The use of metformin, acarbose, and pioglitazone was significantly lower (p = 0.037, p = 0.048, and p = 0.042, respectively) than at the beginning of the study in the Vitamin D3 therapy group. The units of Lispro, Aspart, and Glargine insulin were lower in the Vitamin D3 group at the end of the study (p = 0.031, p = 0.037, and p = 0.035, respectively) than in the placebo group. Conclusions: in type 2 diabetic patients with Vitamin D deficiency, the restoration of value in the Vitamin D standard has led not only to an improvement in the glyco-metabolic compensation, but also to a reduced posology of some oral hypoglycemic agents and some types of insulin used.

Vitamin D3 hochdosiert dreimal jährlich reduziert Frakturrate

Praxis ◽  
2003 ◽  
Vol 92 (47) ◽  
pp. 2021-2022
Author(s):  
K. Eichler
Keyword(s):  
Vitamin D3
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