scholarly journals Electrophoretic Study of Lactate Dehydrogenase and Alkaline Phosphatase Isoenzymes of the Mongolian Gerbil(Meriones unguiculatus).

1996 ◽  
Vol 58 (5) ◽  
pp. 401-406
Author(s):  
Masumi SHIMIZU ◽  
Kazumi IIDA ◽  
Haruhiro YOSHIDA ◽  
Kazuhiro SHICHINOHE
Keyword(s):  
Alkaline Phosphatase ◽  
Lactate Dehydrogenase ◽  
Mongolian Gerbil ◽  
Meriones Unguiculatus ◽  
Electrophoretic Study ◽  
Alkaline Phosphatase Isoenzymes

scholarly journals Serum Profile of Lactate Dehydrogenase (LDH) and Alkaline Phosphatase (ALP) in Alcoholic Liver Diseases

2020 ◽  
Author(s):  
Agnieszka Grytczuk ◽  
Ewa Gruszewska ◽  
Anatol Panasiuk ◽  
Bogdan Cylwik ◽  
Lech Chrostek
Keyword(s):  
Alkaline Phosphatase ◽  
Lactate Dehydrogenase ◽  
Liver Diseases ◽  
Alcoholic Hepatitis ◽  
Relative Concentration ◽  
Alcoholic Cirrhosis ◽  
Total Activity ◽  
Relative Level ◽  
Alkaline Phosphatase Isoenzymes ◽  
Alcoholic Liver Diseases

Abstract Background: Alcohol‐related liver diseases affect the capability of the liver for the synthesis of proteins including enzymes. Among enzymes two expose the liver specific isoenzymes. There are lactate dehydrogenase and alkaline phosphatase. The purpose of this study was to explore the profile of lactate dehydrogenase and alkaline phosphatase isoenzymes in alcoholic liver diseases.Methods: The serum profile of lactate dehydrogenase and alkaline phosphatase isoenzymes was studied in alcoholic cirrhosis and alcoholic hepatitis by electrophoresis method on agarose gel.Results: The relative concentration of LDH 1 isoenzyme is decreased in alcoholic hepatitis, but LDH 4 and LDH 5 isoenzymes are increased. In addition, the relative level of LDH 5 isoenzyme is increased in alcoholic cirrhosis. The concentrations of intermediate isoenzymes (LDH 2 and LDH 3) are reduced in alcoholic cirrhosis. There were also an increase of liver ALP isoenzyme and parallel decrease in its bone isoenzyme in alcoholic hepatitis and cirrhosis. The severity of liver cirrhosis, expressed as a Child-Pugh score, didn’t affect total activity of both enzymes but effects the relative concentration of LDH 2, LDH 3 and LDH 4 isoenzymes.Conclusions: The serum profile of lactate dehydrogenase and alkaline phosphatase isoenzymes alters in alcoholic liver diseases and differs between them. The differences can be explained by the tissue prevalence and metabolic preferences of isoenzymes.

Lactate dehydrogenase and alkaline phosphatase isoenzymes and protein-bound sialic acid in regenerating rat liver

1986 ◽  
Vol 186 (2) ◽  
pp. 103-107 ◽  
Author(s):  
D. Allalouf ◽  
S. Schwarzman ◽  
H. Levinsky ◽  
N. Feller ◽  
J. Hart ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Sialic Acid ◽  
Lactate Dehydrogenase ◽  
Rat Liver ◽  
Regenerating Rat Liver ◽  
Alkaline Phosphatase Isoenzymes
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