scholarly journals Evaluation of Extravascular Thermal Volume in the Lung in Dogs with Endotoxin-Induced Shock by Double Indicator Dilution Method using Heat and Sodium Ions.

1993 ◽  
Vol 55 (1) ◽  
pp. 87-91 ◽  
Author(s):  
Masahiro TAGAWA ◽  
Shozo OKANO ◽  
Yasushi HARA ◽  
Hiroyasu EJIMA ◽  
Shigekatsu MOTOYOSHI ◽  
...  
Keyword(s):  
Indicator Dilution ◽  
Dilution Method ◽  
Sodium Ions ◽  
Double Indicator Dilution ◽  
Double Indicator Dilution Method

scholarly journals An Appraisal of the Double Indicator-Dilution Method for the Estimation of Mitral Regurgitation in Human Subjects

Circulation ◽  
1961 ◽  
Vol 23 (1) ◽  
pp. 64-68 ◽  
Author(s):  
WILLIAM S. WILSON ◽  
RALPH L. BRANDT ◽  
RICHARD D. JUDGE ◽  
JOE D. MORRIS ◽  
MARY E. CLIFFORD
Keyword(s):  
Mitral Regurgitation ◽  
Human Subjects ◽  
Indicator Dilution ◽  
Dilution Method ◽  
Double Indicator Dilution ◽  
Double Indicator Dilution Method

Changes in cerebral blood flow and oxygen metabolism during moderate hypothermia in patients with severe middle cerebral artery infarction

2000 ◽  
Vol 8 (5) ◽  
pp. 1-4 ◽  
Author(s):  
Emanuela Keller ◽  
Thorsten Steiner ◽  
Javier Fandino ◽  
Stefan Schwab ◽  
Werner Hacke
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Ischemic Stroke ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Mild Hypothermia ◽  
Indicator Dilution ◽  
Dilution Method ◽  
Moderate Hypothermia ◽  
Double Indicator Dilution

Object Moderate hypothermia has been reported to be effective in the treatment of postischemic brain edema. The effect of hypothermia on cerebral hemodynamics is a matter of controversial discussion in literature. Clinical studies have yet to be performed in patients with ischemic stroke after induction of hypothermia. Methods Measurements during mild hypothermia (33–34°C) were made in six patients with severe ischemic stroke involving the middle cerebral artery territory. Hypothermia was induced as soon as possible and maintained for 48 to 72 hours. Cerebral blood flow (CBF) and cerebral metabolic rate of oxygen (CMRO2) were estimated by a new double-indicator dilution method. Measurements of CBF were made during normothermia, immediately after induction of hypothermia, at the end of hypothermia, and after rewarming. A total of 19 measurements of CBF and jugular bulb O2 saturation were made. Immediately after induction of hypothermia, CBF decreased in all patients. During late hypothermia, CBF improved in patients who survived but remained diminished in the two patients who died. Reduced CMRO2 levels were observed during all phases of hypothermia in all but one case. Conclusions Preliminary oberservations indicate that moderate hypothermia seems to reduce CMRO2 Immediately after induction of hypothermia, CBF may decrease in all patients. During late hypothermia CBF seems to recover in patients with good outcome but remains diminished in patients who die. Serial bedside CBF measurements with the new double-indicator dilution technique may be useful to describe cerebral hemodynamic characteristics in patients with severe ischemic stroke during hypothermia.

Influence of size of emboli on extravascular lung water

1989 ◽  
Vol 67 (2) ◽  
pp. 663-670 ◽  
Author(s):  
C. A. Dawson ◽  
D. A. Rickaby ◽  
J. H. Linehan
Keyword(s):  
Dilution Method ◽  
Lung Water ◽  
Vascular Volume ◽  
Lung Lobe ◽  
Double Indicator Dilution ◽  
Bead Diameter ◽  
Pass Through ◽  
Extravascular Volume ◽  
Double Indicator Dilution Method ◽  
Lung Lobes

We examined the influence of the size of emboli on the vascular volume (QL) and extravascular volume (Qev) accessible to 3HOH during a single pass through an isolated dog lung lobe using the double indicator-dilution method with 125I-human serum albumin as the vascular indicator. As successively more beads of a given diameter (58, 548, or 3,175 microns) were introduced into a lung lobe, a linear relationship between QL and Qev was obtained as they both decreased. The slope of the graph of QL vs. Qev with progressive embolism was directly proportional to the bead diameter. This suggested an approach for estimating the total vascular volume in vessels smaller than the diameter of the beads before embolization, referred to as Qm. If it is assumed that most of the transvascular diffusional exchange of 3HOH occurs in vessels smaller than the smallest beads (mainly capillaries) and that vessel obstruction does not change the ratio of Qev to the perfused capillary volume, the slope of the plot of QL vs. Qev is an estimate of the fraction, Qm/QL, of the total vascular volume in vessels smaller than the bead diameter. In the dog lung lobes studied, Qm/QL was approximately 0.64 for 58-microns vessels, 0.75 for 548-microns vessels, and 0.82 for 3,175-microns vessels. The results suggest that, with occlusion of vessels greater than or equal to 58 microns, 3HOH does not diffuse significantly into unperfused regions.(ABSTRACT TRUNCATED AT 250 WORDS)

The Stewart–Hamilton Equations and The Indicator Dilution Method

1978 ◽  
Vol 34 (4) ◽  
pp. 666-675 ◽  
Author(s):  
M. Profant ◽  
K. Vyska ◽  
U. Eckhardt
Keyword(s):  
Indicator Dilution ◽  
Dilution Method ◽  
Hamilton Equations
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