scholarly journals Dual Infection with Canine Distemper Virus and Infectious Canine Hepatitis Virus (Canine Adenovirus Type 1) in a Dog.

1993 ◽  
Vol 55 (4) ◽  
pp. 699-701 ◽  
Author(s):  
Yoshiyasu KOBAYASHI ◽  
Kenji OCHIAI ◽  
Chitoshi ITAKURA
Keyword(s):  
Canine Distemper Virus ◽  
Hepatitis Virus ◽  
Adenovirus Type ◽  
Dual Infection ◽  
Canine Distemper

scholarly journals A retrospective study on the presence of selected infectious agents in lung samples of cats with pneumonia

2020 ◽  
Author(s):  
Eva Schmal-Filius ◽  
Nora Nedorost ◽  
Christiane Weissenbacher-Lang ◽  
Herbert Weissenböck
Keyword(s):  
Retrospective Study ◽  
Canine Distemper Virus ◽  
Pasteurella Multocida ◽  
Infectious Agents ◽  
Canine Distemper ◽  
Herpesvirus Type ◽  
Feline Herpesvirus ◽  
Feline Coronavirus ◽  
Feline Herpesvirus Type 1

AbstractThe causative role of some infectious agents found in cases of feline pneumonia is under debate, because they are also part of the physiological microbiota of the respiratory tract of healthy animals. In this retrospective study, archived formalin-fixed and paraffin-wax-embedded lung samples of 69 severe and lethal cases of pneumonia in cats were examined by immunohistochemistry (IHC) for the detection of nine selected infectious agents: Pasteurella multocida, Bordetella bronchiseptica, Mycoplasma felis, M. gateae, Chlamydia felis, feline herpesvirus type 1, feline coronavirus, canine distemper virus, and Toxoplasma gondii. The intention was to elucidate their immediate involvement in pneumonia formation. Due to the cross-reactivity of the applied antibodies, a species-specific polymerase chain reaction (PCR) for both targeted Mycoplasma species was applied additionally. In the 42 cases (60.9%) positive for at least one pathogen, several agents were present in a high proportion of the samples (P. multocida – 34.8%, B. bronchiseptica – 29.0%), while others were present in a moderate (feline herpesvirus type 1 – 18.8%, M. gateae – 13.0%, M. felis – 10.1%) or low percentage (T. gondii – 1.4%). All samples were negative for C. felis, feline coronavirus and canine distemper virus. Mixed infections of up to four pathogens were more frequent than single infections. Mycoplasma preferably colonised lung tissue damaged by other pathogens because they never occurred as single infections. Pasteurella multocida, B. bronchiseptica, M. felis, feline herpesvirus type 1 and T. gondii showed abundant replication within lung lesions, thus suggesting a prominent role in pneumonia formation.

scholarly journals Dual infection with an emergent strain of canine distemper virus and canine parvovirus in an Arctic wolf under managed care

2019 ◽  
Vol 31 (4) ◽  
pp. 594-597 ◽  
Author(s):  
Justin M. Stilwell ◽  
Eman Anis ◽  
Rebecca P. Wilkes ◽  
Daniel R. Rissi
Keyword(s):  
Canine Distemper Virus ◽  
Wild Type Strain ◽  
Cell Types ◽  
Dual Infection ◽  
Acute Onset ◽  
Canine Parvovirus ◽  
Long Bones ◽  
Canine Distemper ◽  
Conventional Pcr ◽  
Intracytoplasmic Inclusions

A 6-wk-old managed male Arctic wolf with lethargy, drooling, dehydration, elevated temperature, and acute onset of seizures was submitted for autopsy. The wolf had been vaccinated with a multivalent vaccine exactly 2 wk prior to presentation. Grossly, long bones were brittle and easily fractured under pressure; the intestinal contents were mucoid and yellow. Histologically, there was widespread lymphoid and hematopoietic necrosis, failure of endochondral ossification within long bones, as well as intranuclear and intracytoplasmic inclusions in various tissues and cell types. Canine distemper virus was detected in numerous tissues by IHC and confirmed by RT-rtPCR and sequencing as an American-4 strain, an emerging strain in domestic dogs and wildlife species in the southeastern United States. The clinical and pathologic findings associated with this emergent CDV strain have not been reported previously in wolves, to our knowledge. Canine parvovirus 2 (CPV-2b) was also detected in the spleen by IHC and confirmed by conventional PCR as a wild-type strain. The exact impact of CPV-2b on the clinical course is unknown. Early vaccination in this case may have predisposed this Artic wolf to developing clinical disease.

scholarly journals Simultaneous canine distemper encephalitis and canine parvovirus infection with distemper-associated cardiac necrosis in a pup

2003 ◽  
Vol 33 (6) ◽  
pp. 1149-1151 ◽  
Author(s):  
Selwyn Arlington Headley ◽  
Taís Berelli Saito
Keyword(s):  
Canine Distemper Virus ◽  
Dual Infection ◽  
Canine Parvovirus ◽  
Canine Distemper ◽  
Enamel Hypoplasia ◽  
Corneal Ulceration ◽  
Myocardial Degeneration ◽  
Simultaneous Infection ◽  
Cardiac Necrosis ◽  
Demyelinating Encephalitis

Simultaneous infection of canine distemper virus and canine parvovirus associated with distemper myocardial degeneration and necrosis is described in a pup. The dog demonstrated myoclonus, nystagmus, enamel hypoplasia, abdominal pustules, and bilateral corneal ulceration clinically. Demyelinating encephalitis, myocardial degeneration and necrosis with mineralization, and necrosis, hemorrhage and fusion of intestinal villi were observed. The lesions observed in this dog are characteristic of a dual infection of canine distemper virus and canine parvovirus.

scholarly journals Measles virus and canine distemper virus target proteins into a TAP-independent MHC class I-restricted antigen-processing pathway

2001 ◽  
Vol 82 (2) ◽  
pp. 441-447 ◽  
Author(s):  
Claudia Neumeister ◽  
Ralph Nanan ◽  
Tatjana I. Cornu ◽  
Carsten G. K. Lüder ◽  
Volker ter Meulen ◽  
...  
Keyword(s):  
Nucleocapsid Protein ◽  
Measles Virus ◽  
Canine Distemper Virus ◽  
Antigen Processing ◽  
Matrix Protein ◽  
Cytotoxic T Cells ◽  
Viral Proteins ◽  
Canine Distemper ◽  
The Matrix

After infection of CEM174.T2 cells [deficient for the transporter of antigen presentation (TAP)] with measles virus (MV) the nucleocapsid protein is recognized by Ld-restricted cytotoxic T cells in a TAP-independent, chloroquine-sensitive fashion. Presentation via the TAP-independent pathway requires virus replication. During MV infection of the cell the nucleocapsid as well as the matrix protein enter the endolysosomal compartment as indicated by colocalization with the lysosomal-associated membrane protein 1 (LAMP-1). Similarly, the nucleocapsid protein of canine distemper virus (CDV) is recognized in a TAP-independent fashion. In addition, a recombinant MV expressing bacterial β-galactosidase protein is able to introduce the recombinant antigen into the TAP-independent pathway whereas a vaccinia virus expressing β-galactosidase is not. These data and a report about TAP-independent recognition of parainfluenza virus type 1 suggest that members of the Paramyxoviridae family regularly introduce viral proteins into the TAP-independent antigen-processing pathway.

scholarly journals Simultaneous Canine Distemper Virus, Canine Adenovirus Type 2, and Mycoplasma Cynos Infection in a Dog with Pneumonia

2007 ◽  
Vol 44 (4) ◽  
pp. 508-512 ◽  
Author(s):  
S. Chvala ◽  
V. Benetka ◽  
K. Möstl ◽  
F. Zeugswetter ◽  
J. Spergser ◽  
...  
Keyword(s):  
Lung Tissue ◽  
Inclusion Bodies ◽  
Canine Distemper Virus ◽  
Adenovirus Type ◽  
Lung Cells ◽  
Canine Distemper ◽  
Triple Infection ◽  
Polymerase Chain

The present case is the first description of a triple infection with canine distemper virus (CDV), canine adenovirus (CAV) type 2, and Mycoplasma cynos in a dog. The 5-month-old female Miniature Pinscher was euthanized because of dyspnea, croaking lung sounds, weight loss, and lymphopenia. Pathologic examination revealed a fibrinous necrotizing pneumonia with large amphophilic intranuclear and acidophilic intracytoplasmatic inclusion bodies in different lung cells. Immunohistochemically, CDV antigen was present in lung and many other organs. In situ hybridization for detection of CAV nucleic acid showed positive signals in the lung only. Polymerase chain reaction of lung tissue and consecutive sequencing of the amplification product identified CAV type 2. Bacteriologic examination of lung tissue yielded large amounts of M cynos. This infection was confirmed by immunohistochemistry detecting abundant positive signals in the lung tissue.

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