scholarly journals Changes in Plasma Testosterone Level and Semen Quality after Frequent Injections of GnRH Analogue in a Beagle Dog with Azoospermia

2009 ◽  
Vol 71 (10) ◽  
pp. 1373-1375 ◽  
Author(s):  
Eiichi KAWAKAMI ◽  
Tatsuya HORI ◽  
Toshihiko TSUTSUI
1995 ◽  
Vol 33 (4) ◽  
pp. 676-678 ◽  
Author(s):  
Nobuko Tabata ◽  
Tadashi Terui ◽  
Mariko Watanabe ◽  
Hachiro Tagami

1976 ◽  
Vol 81 (3) ◽  
pp. 680-684 ◽  
Author(s):  
Richard A. Donald ◽  
Eric A. Espiner ◽  
R. John Cowles ◽  
Joy E. Fazackerley

ABSTRACT Cyproterone acetate (100–150 mg daily) was administered to 8 male patients with excessive libido. Within 3 months a significant fall (P < 0.02) in plasma testosterone was demonstrated. The plasma luteinising hormone (LH) and follicle stimulating hormone (FSH) responses to gonadotrophin releasing hormone (LH/FSH-RH) were also significantly impaired (P < 0.05). A direct correlation between the resting plasma testosterone level and the LH response to LH/FSH-RH was demonstrated (r = 0.743). It is concluded that the fall in plasma testosterone levels in patients receiving cyproterone acetate may be attributed to suppression of LH release, rather than an antiandrogen effect on the testis or hypothalamus.


2009 ◽  
Vol 4 (10) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Kit-Lam Chan ◽  
Bin-Seng Low ◽  
Chin-Hoe Teh ◽  
Prashanta K. Das

The present study investigated the effects of a standardized methanol extract of E. longifolia Jack containing the major quassinoid constituents of 13α(21)-epoxyeurycomanone (1), eurycomanone (2), 13α,21-dihydroeurycomanone (3) and eurycomanol (4) on the epididymal spermatozoa profile of normal and Andrographis paniculata induced infertile rats. The standardized MeOH extract at doses of 50, 100 and 200 mg/kg, the EtOAc fraction (70 mg/kg), and standardized MeOH extract at 200 mg/kg co-administered with the EtOAc fraction of A. paniculata at 70 mg/kg were each given orally to male Sprague-Dawley albino rats for 48 consecutive days. The spermatozoa count, morphology, motility, plasma testosterone level and Leydig cell count of the animals were statistically analyzed by ANOVA with a post-hoc Tukey HSD test. The results showed that the sperm count of rats given the standardized MeOH extract alone at doses of 50, 100 and 200 mg/kg were increased by 78.9, 94.3 and 99.2 %, respectively when compared with that of control (p < 0.01). The low count, poor motility and abnormal morphology of the spermatozoa induced by the A. paniculata fraction were significantly reversed by the standardized MeOH extract of E. longifolia (p < 0.001). The plasma testosterone level of the rats treated with the standardized MeOH extract at 200 mg/kg was significantly increased (p < 0.01) when compared with that of the control and infertile animals. The spermatocytes in the seminiferous tubules and the Leydig cells appeared normal. Testosterone level was significantly higher in the testes (p < 0.01) than in the plasma after 30 days of oral treatment with the standardized MeOH extract. Interestingly, eurycomanone (2) alone was detected in the rat testis homogenates by HPLC-UV and confirmed by LC/MS, and may have contributed towards the improvement of sperm quality. Thus, the plant may potentially be suitable for the management of male infertility.


2010 ◽  
Vol 9 (2) ◽  
pp. 86-87
Author(s):  
M.G. Park ◽  
K.W. Ko ◽  
M.M. Oh ◽  
D.K. Yoon ◽  
J.J. Kim ◽  
...  

Steroids ◽  
1974 ◽  
Vol 23 (6) ◽  
pp. 921-928 ◽  
Author(s):  
Fouad M. Badr ◽  
Andrzej Bartke

1986 ◽  
Vol 43 (3) ◽  
pp. 459-468 ◽  
Author(s):  
F. M. S. Al-Nakib ◽  
G. A. Lodge ◽  
J. B. Owen

ABSTRACTTwo experiments were designed to study the effect of rearing method, female company, and repeated libido and semen tests on the pattern of sexual development of ram lambs. Four artificial rearing treatments (AR) were compared with natural rearing (NR) in one experiment and four artificial compared with three natural rearing treatments in a second experiment. Lambs on AR treatments in both experiments, as well as naturally reared lambs in the second experiment, were reared with or without females either before and/or after weaning. Half the lambs in the second experiment were libido and semen tested, and their mean plasma testosterone level was also measured, while the rest were only tested at the end of the experiment. The effect of method of rearing and female company on body growth, testes diameter, libido and semen quality were also investigated.A close relationship was found between body weight and sexual characteristics (for example, testis diameter, semen traits, libido, testosterone level and age at the onset of sexual maturity). NR resulted in faster growth than AR but was not appreciably different from early weaned-naturally reared treatments. It was also observed that mating performance improved steadily with advancement in age and increase in body weight. The onset of sexual maturity was attained at a minimum of 23 kg body weight and a minimum of 198 days of age. However, the heavier the lamb when sexually mature, the better its mating performance.Previous libido tests of ram lambs improved their subsequent mating performance, but had no effect on semen quality. However, libido tests did not improve the performance of those ram lambs which did not exhibit initial libido.It is suggested that early weaning at 2 months of age could be a suitable system for ram lambs weaned off their mothers for breeding purposes. These lambs should be reared as an all-male group but libido tested at monthly intervals commencing at 3 months of age. The criteria for selecting these lambs at an earlier age should be body weight and testis diameter.


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